Results 91 to 100 of about 535,578 (267)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Energy dependence of the 13C + 16O scattering and quasi-molecular absorptian potential [PDF]

Ядерна фізика та енергетика, 2010
Experimental data of the 13С + 16O elastic scattering at the energies Еc.m.. = 6.28 - 59.17 MeV were analyzed within the optical model and coupled-reaction-channels method. The energy dependence for the 13С + 16O potential of the Woods - Saxon type with
A. T. Rudchik, Yu. O. Shyrma, V. A. Plujko, O. A. Ponkratenko, I. V. Simenog   +4 more
doaj  

Forced response of shrouded blades with a coupled static/dynamic approach [PDF]

, 2011
A coupled static-dynamic method is proposed and applied to bladed disks with shrouds, in order to calculate the nonlinear forced response in presence of friction damping in the frequency domain.
Zucca, Stefano, Gulisano, Andrea, Firrone, Christian Maria   +2 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Elastic and inelastic scattering of 15N ions by 6Li nuclei at energy 81 MeV

Ядерна фізика та енергетика, 2019
Angular distributions of the elastic and inelastic scattering of 15N ions by 6Li nuclei were measured at the energy Elab(15N) = 81 MeV. The data were analyzed within the coupled-reaction-channels method (CRC).
A. T. Rudchik, A. A. Rudchik, O. O. Chepurnov, K. Rusek, K. W. Kemper, E. Piasecki, A. Stolarz, A. Trczinska, Val. M. Pirnak, O.A. Ponkratenko, I. Strojek, E. I. Koshchy, R. Siudak, S. B. Sakuta, A. P. Ilyin, Yu. M. Stepanenko, V. V. Uleshchenko, Yu. O. Shyrma   +17 more
doaj   +1 more source

Shape Optimization Using the Aero-structural Coupled Adjoint Approach for Viscous Flows [PDF]

, 2011
The aero-structural coupled adjoint approach here is an efficient approach to compute the gradients of the aerodynamic coefficients obtained from coupled fluid-structure simulations.
Brezillon, Joel, Abu-Zurayk, Mohammad
core  

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Exploring dissipative processes at high angular momentum in 58Ni+60Ni reactions

EPJ Web of Conferences, 2016
Current coupled channels (CC) models treat fusion as a coherent quantum-mechanical process, in which coupling between the collective states of the colliding nuclei influences the probability of fusion in near-barrier reactions.
Williams E., Hinde D.J., Dasgupta M., Carter I.P., Cook K.J., Jeung D.Y., Luong D.H., McNeil S.D., Palshetkar C.S., Rafferty D.C., Ramachandran K., Simenel C., Simpson E.C., Wakhle A.   +13 more
doaj   +1 more source