Results 71 to 80 of about 535,578 (267)

A Robust and Rapid Method of Producing Soluble, Stable, and Functional G-Protein Coupled Receptors [PDF]

, 2011
Membrane proteins, particularly G-protein coupled receptors (GPCRs), are notoriously difficult to express. Using commercial E.coli cell-free systems with the detergent Brij-35, we could rapidly produce milligram quantities of 13 unique GPCRs ...
Braun, Dieter, Shuguang Zhang, Baaske Philipp, Moran Jerabek-Willemsen, Geissler, Sandra, Duhr, Stefan, Duhr Stefan, Corin, Karolina A., Sandra Geissler, Wienken Christoph J., Christoph J. Wienken, Geissler Sandra, Jerabek-Willemsen, Moran, Christoph J Wienken, Zhang Shuguang, Stefan Duhr, Emily Brown, Wang Xiaoqiang, Philipp Baaske, Deepali B. Ravel, Brown, Emily, Song Junyao, Xiaoqiang Wang, Braun Dieter, Karolina Corin, Junyao Song, Wang, Xiaoqiang, Dieter Braun, Baaske, Philipp, Wienken, Christoph J., Ravel Deepali B., Corin, Karolina, Ravel, Deepali B., Brown Emily, Song, Junyao, Jerabek-Willemsen Moran, Corin Karolina, Zhang, Shuguang, Deepali B Ravel, Brown, Emily E., Ra Geissler   +40 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Analysis of complex nonlinear reaction-diffusion equations [PDF]

, 2008
A mathematical analysis has been carried out for some nonlinear reaction- diffusion equations on open bounded convex domains Ω C R(^d)(d < 3) with Robin boundary conditions- Existence, uniqueness and continuous dependence on initial data of weak and ...
Al-Ofl, Abdalaziz Saleem
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

14C(11B, 9Be)16N reaction mechanisms and potential of the 9Be + 16N interaction [PDF]

Ядерна фізика та енергетика, 2013
New experimental data for differential cross sections of the 14С(11B, 9Be)16N reaction were measured for the ground states of 9Be and 16N nuclei as well as for the excited states of 16N at the energy Elab.(11В) = 45 MeV.
S. Yu. Mezhevych, A. T. Rudchik, K. Rusek, E. I. Koshchy, S. Kliczewski, A. V. Mokhnach, A. A. Rudchik, S. B. Sakuta, R. Siudak, B. Czech, J. Choiński, A. Szczurek   +11 more
doaj  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

7Li(15N,14C)8Be reaction and 13,14C + 8Be nuclei interactions

Ядерна фізика та енергетика, 2017
Angular distributions of the 7Li(15N,14C)8Be reaction were measured at the energy Elab(15N) = 81 MeV. The reaction data were analyzed within coupled-reaction-channels (CRC) method. The 7Li + 15N elastic and inelastic scattering and the more important one-
А. Т. Rudchik, А. А. Rudchik, L. M. Muravynets, K. W. Kemper, К. Rusek, E. І. Koshchy, E. Piasecki, A. Trczinska, Val. М. Pirnak, О. А. Ponkratenko, V. А. Plujko, I. Strojek, A. Stolarz, S. B. Sakuta, А. P. Ilyin, u. M. Stepanenko, . V. Uleshchenko, Yu. O. Shyrma   +17 more
doaj  

Elastic and inelastic scattering of 11B ions by 14C at 45 MeV [PDF]

Ядерна фізика та енергетика, 2012
New experimental data for differential cross sections of 14С(11B, 11B)14С inelastic scattering at the energy Elab.(11В) = 45 MeV for transitions of 11B nucleus to the excited states of 2,12 - 8,56 MeV were obtained.
S. Yu. Mezhevych, A. T. Rudchik, K. Rusek, E. I. Koshchiy, S. Kliczewski, V. M. Kir'yanchuk, A. A. Rudchik, S. B. Sakuta, R. Siudak, B. Czech, J. Choinski, A. Szczurek   +11 more
doaj  

Fusion excitation function measurement for 6Li+64Ni at near-barrier energies

EPJ Web of Conferences, 2015
Total fusion excitation function has been measured for the reaction of weakly bound 6Li projectile on medium mass 64Ni target at energies near the Coulomb barrier of the system.
Shaikh Md. Moin, Roy Subinit, Rajbanshi S., Pradhan M. K., Mukherjee A., Basu P., Pal S., Nanal V., Pillay R. G., Shrivastav A.   +9 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source