Results 51 to 60 of about 535,578 (267)
On the hierarchical classification of G Protein-Coupled Receptors [PDF]
, 2007 Motivation: G protein-coupled receptors (GPCRs) play an important role in many physiological systems by transducing an extracellular signal into an intracellular response. Over 50% of all marketed drugs are targeted towards a GPCR.
Matthew N. Davies +11 more
core +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Four-body continuum-discretized coupled-channels calculations: Application to 6He+64Zn at 13.6 MeV [PDF]
, 2009 The recently developed four-body continuum-discretized coupled-channels (CDCC) method, making use of the binning procedure [1], is applied to the reaction 6He+64Zn at 13.6 MeV (around the Coulomb barrier). Excellent agreement with available elastic data [
Tostevin, Jeffrey A. +5 more
core +6 more sources
Energy dependence of the 6Li + 16O scattering and isotopic differences between potentials of the 6,7Li + 16O interactions [PDF]
Ядерна фізика та енергетика, 2012 Experimental data of the 6Li + 16O elastic scattering at Ec.m.. = 3.27 - 36.8 MeV known from literature, were analyzed within the optical model and coupled-reaction-channels method.
A. T. Rudchik, +7 more
doaj
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Elastic and inelastic scattering of 18O ions on 12C nuclei [PDF]
Ядерна фізика та енергетика, 2009 Angular distributions of the 12C + 18O elastic and inelastic scattering were measured at the energy Elab(18O) = 105 MeV (Ec.m. = 42 MeV). These data and data known from the literature at the energies Ec.m. = 12.9 - 56 МеV were analysed within the optical
A. T. Rudchik +17 more
doaj
Switching and diffusion models for gene regulation networks [PDF]
, 2009 We analyze a hierarchy of three regimes for modeling gene regulation. The most complete model is a continuous time, discrete state space, Markov jump process.
Higham, Desmond J. +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source