Results 51 to 60 of about 76,810 (224)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Elastic and inelastic scattering of 11B ions by 14C at 45 MeV [PDF]

Ядерна фізика та енергетика, 2012
New experimental data for differential cross sections of 14С(11B, 11B)14С inelastic scattering at the energy Elab.(11В) = 45 MeV for transitions of 11B nucleus to the excited states of 2,12 - 8,56 MeV were obtained.
S. Yu. Mezhevych, A. T. Rudchik, K. Rusek, E. I. Koshchiy, S. Kliczewski, V. M. Kir'yanchuk, A. A. Rudchik, S. B. Sakuta, R. Siudak, B. Czech, J. Choinski, A. Szczurek   +11 more
doaj  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

7Li(15N,14C)8Be reaction and 13,14C + 8Be nuclei interactions

Ядерна фізика та енергетика, 2017
Angular distributions of the 7Li(15N,14C)8Be reaction were measured at the energy Elab(15N) = 81 MeV. The reaction data were analyzed within coupled-reaction-channels (CRC) method. The 7Li + 15N elastic and inelastic scattering and the more important one-
А. Т. Rudchik, А. А. Rudchik, L. M. Muravynets, K. W. Kemper, К. Rusek, E. І. Koshchy, E. Piasecki, A. Trczinska, Val. М. Pirnak, О. А. Ponkratenko, V. А. Plujko, I. Strojek, A. Stolarz, S. B. Sakuta, А. P. Ilyin, u. M. Stepanenko, . V. Uleshchenko, Yu. O. Shyrma   +17 more
doaj  

7Li(18O, 17N)8Be reaction and the 17N + 8Be-potential [PDF]

Ядерна фізика та енергетика, 2010
Angular distributions of the 7Li(18O, 17N)8Be reaction were measured for the transitions to the ground states of 8Be and 17N and excited states of 17N at the energy Elab(18O) = 114 MeV. The data were analyzed with coupled-reaction-channels method for one-
A. T. Rudchik, Yu. M. Stepanenko, A. A. Rudchik, O. A. Ponkratenko, E. I. Koshchy, S. Kliczewski, K. Rusek, A. Budzanowski, S. Yu. Mezhevych, Val. M. Pirnak, I. Skwirczyńska, R. Siudak, B. Czech, A. Szczurek, J. Choiński, L. Głowacka   +15 more
doaj  

Fusion excitation function measurement for 6Li+64Ni at near-barrier energies

EPJ Web of Conferences, 2015
Total fusion excitation function has been measured for the reaction of weakly bound 6Li projectile on medium mass 64Ni target at energies near the Coulomb barrier of the system.
Shaikh Md. Moin, Roy Subinit, Rajbanshi S., Pradhan M. K., Mukherjee A., Basu P., Pal S., Nanal V., Pillay R. G., Shrivastav A.   +9 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Analysis of the total, Coulomb and nuclear breakups in 6,7Li on 58Ni and 208Pb target masses [PDF]

EPJ Web of Conferences
We use the Continuum Discretized Coupled Channels (CDCC) method to study the total,Coulomb and nuclear breakups in 6,7Li on 58Ni and 208Pb target masses.
Ndala Lucas Vusi, Lekala Mantile Leslie
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source