Results 41 to 50 of about 76,810 (224)

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Elastic and inelastic scattering of 18O ions by 6Li at 114 MeV and isotopic differences of 6, 7Li + 18O and 6Li + 16, 18O nuclei interactions [PDF]

Ядерна фізика та енергетика, 2012
Angular distributions of the 6Li + 18O elastic and inelastic scattering as well as the 6Li(18O, Х) reactions with production of 16,17,19O + 8,7,5Li, 14,15,16,17N + 10,9,8,7Be and 12,13,14C + 12,11,10B nuclei were measured at Elab(18O) = = 114 MeV.
A. T. Rudchik, R. M. Zelinskyi, A. A. Rudchik, Val. M. Pirnak, S. Kliczewski, E. I. Koshchy, K. Rusek, V. A. Plujko, O. A. Ponkratenko, S. Yu. Mezhevych, A. P. Ilyin, V. V. Uleschenko, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +15 more
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Elastic and inelastic scattering of 12C ions by 7Li at 115 MeV [PDF]

Ядерна фізика та енергетика, 2013
Angular distributions of the 7Li + 12C elastic and inelastic scattering as well as the 7Li(14N, Х) reactions with exited stable and unstable nuclei with Z = 3 6 were measured at Elab(12C) = 115 MeV.
A. T. Rudchik, V. Yu. Kanishchev, A. A. Rudchik, O. A. Ponkratenko, E. I. Koshchy, S. Kliczewski, K. Rusek, V. A. Plujko, S. Yu. Mezhevych, Val. M. Pirnak, A. P. Ilyin, V. V. Uleshchenko, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +15 more
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Elastic and inelastic scattering of the 14C + 18O nuclei [PDF]

Ядерна фізика та енергетика, 2010
New angular-distribution data of 14С + 18О elastic and inelastic scattering at the energy Elab(18O) = 105 MeV were obtained firstly. The data were analysed within the optical model and coupled-reaction-channels methods including contributions from most ...
A. T. Rudchik, Yu. O. Shyrma, E. I. Koshchy, S. Kliczewski, B. G. Novatsky, O. A. Ponkratenko, E. Piasecki, G. P. Romanyshyna, K. Rusek, Yu. M. Stepanenko, I. Strojek, S. B. Sakuta, A. Budzanowski, L. Głowacka, I. Skwirczyńska, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +18 more
doaj  

Simultaneous analysis of elastic, breakup, and fusion channels for 6He induced reactions at energies near the Coulomb barrier

EPJ Web of Conferences, 2011
We present some recent applications of the Continuum-Discretized Coupled-Channels (CDCC) and Coupled-Reaction-Channels (CRC) methods to the study of reactions induced by weakly-bound nuclei on stable targets. The methods are applied to the scattering of
Fernández-García J.P., Moro A.M., Alvarez M.A.G., Rodríguez-Gallardo M.   +3 more
doaj   +1 more source

Elastic and inelastic scattering of 10B ions by 6Li nuclei at energy 51 MeV

Ядерна фізика та енергетика, 2020
New experimental data of angular distributions for the elastic and inelastic scattering of 10B ions by 6Li nuclei were obtained at the energy Elab(10B) = 51 MeV for the ground and excited 2.18 – 5.7 MeV states of 6Li and 0.7 – 6.56 MeV states of 10В ...
A. T. Rudchik, A. A. Rudchik, O. O. Chepurnov, K. Rusek, K. W. Kemper, E. I. Koshchy, S. Yu. Mezhevych, Val. M. Pirnak, O. A. Ponkratenko, A. Stolarz, R. Siudak, A. P. Ilyin, B. V. Mishchenko, Yu. M. Stepanenko, V. V. Uleshchenko, Yu. O. Shyrma   +15 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

14C(11B, 9Be)16N reaction mechanisms and potential of the 9Be + 16N interaction [PDF]

Ядерна фізика та енергетика, 2013
New experimental data for differential cross sections of the 14С(11B, 9Be)16N reaction were measured for the ground states of 9Be and 16N nuclei as well as for the excited states of 16N at the energy Elab.(11В) = 45 MeV.
S. Yu. Mezhevych, A. T. Rudchik, K. Rusek, E. I. Koshchy, S. Kliczewski, A. V. Mokhnach, A. A. Rudchik, S. B. Sakuta, R. Siudak, B. Czech, J. Choiński, A. Szczurek   +11 more
doaj