Results 41 to 50 of about 71,710 (221)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Elastic and inelastic scattering of 12C ions by 7Li at 115 MeV [PDF]

Ядерна фізика та енергетика, 2013
Angular distributions of the 7Li + 12C elastic and inelastic scattering as well as the 7Li(14N, Х) reactions with exited stable and unstable nuclei with Z = 3 6 were measured at Elab(12C) = 115 MeV.
A. T. Rudchik, V. Yu. Kanishchev, A. A. Rudchik, O. A. Ponkratenko, E. I. Koshchy, S. Kliczewski, K. Rusek, V. A. Plujko, S. Yu. Mezhevych, Val. M. Pirnak, A. P. Ilyin, V. V. Uleshchenko, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +15 more
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Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Elastic and inelastic scattering of the 14C + 18O nuclei [PDF]

Ядерна фізика та енергетика, 2010
New angular-distribution data of 14С + 18О elastic and inelastic scattering at the energy Elab(18O) = 105 MeV were obtained firstly. The data were analysed within the optical model and coupled-reaction-channels methods including contributions from most ...
A. T. Rudchik, Yu. O. Shyrma, E. I. Koshchy, S. Kliczewski, B. G. Novatsky, O. A. Ponkratenko, E. Piasecki, G. P. Romanyshyna, K. Rusek, Yu. M. Stepanenko, I. Strojek, S. B. Sakuta, A. Budzanowski, L. Głowacka, I. Skwirczyńska, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +18 more
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In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Elastic and inelastic scattering of 18O ions on 12C nuclei [PDF]

Ядерна фізика та енергетика, 2009
Angular distributions of the 12C + 18O elastic and inelastic scattering were measured at the energy Elab(18O) = 105 MeV (Ec.m. = 42 MeV). These data and data known from the literature at the energies Ec.m. = 12.9 - 56 МеV were analysed within the optical
A. T. Rudchik, Yu. O. Shyrma, E. I. Koshchy, S. Kliczewski, B. G. Novatsky, O. A. Ponkratenko, E. Piasecki, G. P. Romanyshyna, K. Rusek, Yu. M. Stepanenko, I. Strojek, S. B. Sakuta, A. Budzanowski, L. Glowacka, I. Skwirczynska, R. Siudak, J. Choinski, A. Szczurek   +17 more
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Simultaneous analysis of elastic, breakup, and fusion channels for 6He induced reactions at energies near the Coulomb barrier

EPJ Web of Conferences, 2011
We present some recent applications of the Continuum-Discretized Coupled-Channels (CDCC) and Coupled-Reaction-Channels (CRC) methods to the study of reactions induced by weakly-bound nuclei on stable targets. The methods are applied to the scattering of
Fernández-García J.P., Moro A.M., Alvarez M.A.G., Rodríguez-Gallardo M.   +3 more
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Elastic and inelastic scattering of 10B ions by 6Li nuclei at energy 51 MeV

Ядерна фізика та енергетика, 2020
New experimental data of angular distributions for the elastic and inelastic scattering of 10B ions by 6Li nuclei were obtained at the energy Elab(10B) = 51 MeV for the ground and excited 2.18 – 5.7 MeV states of 6Li and 0.7 – 6.56 MeV states of 10В ...
A. T. Rudchik, A. A. Rudchik, O. O. Chepurnov, K. Rusek, K. W. Kemper, E. I. Koshchy, S. Yu. Mezhevych, Val. M. Pirnak, O. A. Ponkratenko, A. Stolarz, R. Siudak, A. P. Ilyin, B. V. Mishchenko, Yu. M. Stepanenko, V. V. Uleshchenko, Yu. O. Shyrma   +15 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

14C(11B, 9Be)16N reaction mechanisms and potential of the 9Be + 16N interaction [PDF]

Ядерна фізика та енергетика, 2013
New experimental data for differential cross sections of the 14С(11B, 9Be)16N reaction were measured for the ground states of 9Be and 16N nuclei as well as for the excited states of 16N at the energy Elab.(11В) = 45 MeV.
S. Yu. Mezhevych, A. T. Rudchik, K. Rusek, E. I. Koshchy, S. Kliczewski, A. V. Mokhnach, A. A. Rudchik, S. B. Sakuta, R. Siudak, B. Czech, J. Choiński, A. Szczurek   +11 more
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