Results 61 to 70 of about 337,508 (258)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Elastic and inelastic scattering of 12C ions by 7Li at 115 MeV [PDF]

Ядерна фізика та енергетика, 2013
Angular distributions of the 7Li + 12C elastic and inelastic scattering as well as the 7Li(14N, Х) reactions with exited stable and unstable nuclei with Z = 3 6 were measured at Elab(12C) = 115 MeV.
A. T. Rudchik, V. Yu. Kanishchev, A. A. Rudchik, O. A. Ponkratenko, E. I. Koshchy, S. Kliczewski, K. Rusek, V. A. Plujko, S. Yu. Mezhevych, Val. M. Pirnak, A. P. Ilyin, V. V. Uleshchenko, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +15 more
doaj  

New treatment of breakup continuum in the method of continuum discretized coupled channels [PDF]

, 2003
A new method of pseudo-state discretization is proposed for the method of continuum discretized coupled channels (CDCC) to deal with three-body breakup processes.
E. Hiyama, E. Hiyama, K. Ogata, M. Kamimura, M. Kamimura, M. Yahiro, M. Yahiro, M. Yahiro, M. Yahiro, M. Yahiro, T. Kamizato, T. Matsumoto, Y. Iseri, Y. Sakuragi, Y. Sakuragi   +14 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Elastic and inelastic scattering of the 14C + 18O nuclei [PDF]

Ядерна фізика та енергетика, 2010
New angular-distribution data of 14С + 18О elastic and inelastic scattering at the energy Elab(18O) = 105 MeV were obtained firstly. The data were analysed within the optical model and coupled-reaction-channels methods including contributions from most ...
A. T. Rudchik, Yu. O. Shyrma, E. I. Koshchy, S. Kliczewski, B. G. Novatsky, O. A. Ponkratenko, E. Piasecki, G. P. Romanyshyna, K. Rusek, Yu. M. Stepanenko, I. Strojek, S. B. Sakuta, A. Budzanowski, L. Głowacka, I. Skwirczyńska, R. Siudak, J. Choiński, B. Czech, A. Szczurek   +18 more
doaj  

Elastic and inelastic scattering of 10B ions by 6Li nuclei at energy 51 MeV

Ядерна фізика та енергетика, 2020
New experimental data of angular distributions for the elastic and inelastic scattering of 10B ions by 6Li nuclei were obtained at the energy Elab(10B) = 51 MeV for the ground and excited 2.18 – 5.7 MeV states of 6Li and 0.7 – 6.56 MeV states of 10В ...
A. T. Rudchik, A. A. Rudchik, O. O. Chepurnov, K. Rusek, K. W. Kemper, E. I. Koshchy, S. Yu. Mezhevych, Val. M. Pirnak, O. A. Ponkratenko, A. Stolarz, R. Siudak, A. P. Ilyin, B. V. Mishchenko, Yu. M. Stepanenko, V. V. Uleshchenko, Yu. O. Shyrma   +15 more
doaj   +1 more source

A Global Potential Analysis of the $^{16}$O+$^{28}$Si Reaction Using a New Type of Coupling Potential

, 2002
A new approach has been used to explain the experimental data for the $^{16}$O+$^{28}$Si system over a wide energy range in the laboratory system from 29.0 to 142.5 MeV.
A. Dudek-Ellis, A. M. Kobos, D. Dehnhard, D. M. Brink, D. Schwalm, G. V. Marti, I. Boztosun, I. Boztosun, I. Boztosun, I. Boztosun, J. Barrette, J. Carter, J. Carter, M. A. Franey, M. E. Brandan, P. Braun-Munzinger, P. Braun-Munzinger, P. M. Endt, R. G. Stokstad, R. L. Filho, S. J. Sanders, S. Kahana, S. Kubono, S. Y. Lee, V. N. Bragin, W. D. M. Rae, W. Sciani   +26 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Elastic and inelastic scattering of 18O ions on 12C nuclei [PDF]

Ядерна фізика та енергетика, 2009
Angular distributions of the 12C + 18O elastic and inelastic scattering were measured at the energy Elab(18O) = 105 MeV (Ec.m. = 42 MeV). These data and data known from the literature at the energies Ec.m. = 12.9 - 56 МеV were analysed within the optical
A. T. Rudchik, Yu. O. Shyrma, E. I. Koshchy, S. Kliczewski, B. G. Novatsky, O. A. Ponkratenko, E. Piasecki, G. P. Romanyshyna, K. Rusek, Yu. M. Stepanenko, I. Strojek, S. B. Sakuta, A. Budzanowski, L. Glowacka, I. Skwirczynska, R. Siudak, J. Choinski, A. Szczurek   +17 more
doaj  

Simultaneous analysis of elastic, breakup, and fusion channels for 6He induced reactions at energies near the Coulomb barrier

EPJ Web of Conferences, 2011
We present some recent applications of the Continuum-Discretized Coupled-Channels (CDCC) and Coupled-Reaction-Channels (CRC) methods to the study of reactions induced by weakly-bound nuclei on stable targets. The methods are applied to the scattering of
Fernández-García J.P., Moro A.M., Alvarez M.A.G., Rodríguez-Gallardo M.   +3 more
doaj   +1 more source