Results 111 to 120 of about 2,136,778 (329)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A zero voltage transition interleaved DC-DC converter with reduced voltage stress
Majlesi Journal of Electrical EngineeringThis paper presents an interleaved converter designed to achieve a high voltage gain using a combination of coupled inductors and switched capacitors.
Hosein Talgini +2 more
doaj +1 more source
A Noise-Shifting Differential Colpitts VCO [PDF]
, 2002 A novel noise-shifting differential Colpitts VCO is presented. It uses current switching to lower phase noise by cyclostationary noise alignment and improve the start-up condition.
Aparicio, Roberto, Hajimiri, Ali
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Multimodal Resonance in Strongly Coupled Inductor Arrays [PDF]
IEEE Transactions on Instrumentation and MeasurementMagnetic resonance coupling (MRC) is widely used for wireless power transfer (WPT) applications, but little work has explored how MRC phenomena could be exploited for sensing applications. This paper introduces, validates and evaluates the unique multi-resonant phenomena predicted by circuit theory for over-coupled inductive arrays, and presents eigen ...
Robert R. Hughes +3 more
openaire +2 more sources
Simulating Quantum Spin Hall Effect in Topological Lieb Lattice of Linear Circuit
, 2018 Inspired by the topological insulator circuit proposed and experimentally verified by Jia., et al. \cite{1}, we theoretically realized the topological Lieb lattice, a line centered square lattice with rich topological properties, in a radio-frequency ...
Chen, Hong +4 more
core +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Benefits of the CI-CCS converter
The Journal of Engineering, 2019 An enhanced DC–DC converter is proposed in this paper, based on the combination of the Cuk converter and single-ended primary-inductor converter (SEPIC).
Kumaran S. Nathan +7 more
doaj +1 more source
Maximum Effectiveness of Electrostatic Energy Harvesters When Coupled to Interface Circuits
, 2012 Accepted ...
Green, TC, Mitcheson, PD
core +1 more source