Results 61 to 70 of about 110,100 (307)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Frontiers in Public Health, 2021 The degree of coupling and coordination between the pharmaceutical manufacturing industry and the medical service industry crucially requires improvement by promoting the development of the pharmaceutical manufacturing industry through industrial ...
Meng Hu, Chunhai Tao, Hao Zhou
doaj +1 more source
, 1991 Müller U, Cruse H. The contralateral coordination of walking legs in the crayfish Astacus leptodactylus. I. Experimental results. Biol. Cybern. 1991;64(5):429-436.The coupling mechanisms which coordinate the movement of ipsilateral walking legs in the ...
H. Cruse +3 more
core +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Frontiers in Environmental Science, 2023 Introduction: The development of tourism economy depends on air quality to a large extent, and good air quality is conducive to promoting the development of tourism economy. And it is crucial to understand the coupled and coordinated relationship between
Shuhong Zhao +3 more
doaj +1 more source
The grade division of coupling coordination degree.
, 2021 The grade division of coupling coordination degree.
Jinfu Xu (8194992) +3 more
core +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
PLoS ONEUnder the influence of development strategies with regard to national fitness and health in China, the interactive development between national fitness and national health is becoming increasingly strong.
Dongxu Lin +3 more
doaj +1 more source
Collective Coordinates of the Skyrme Model Coupled with Fermions [PDF]
Physica Scripta, 2003 The problem of construction of fiber bundle over the moduli space of the Skyrme model is considered. We analyse an extension of the original Skyrme model which includes the minimal interaction with fermions. An analogy with modili space of the fermion-monopole system is used to construct a fiber bundle structure over the skyrmion moduli space.
openaire +3 more sources
Coupled catalytic states and the role of metal coordination in Cas9
Nature Catalysis, 2023 AbstractControlling the activity of the CRISPR–Cas9 system is essential to its safe adoption for clinical and research applications. Although the conformational dynamics of Cas9 are known to control its enzymatic activity, details of how Cas9 influences the catalytic processes at both nuclease domains remain elusive.
Anuska Das +6 more
openaire +2 more sources