Results 71 to 80 of about 2,847,915 (169)

Total and covalently closed circular DNA detection in liver tissue of long-term survivors transplanted for HBV-related cirrhosis

, 2010
Life-long prophylaxis against HBV recurrence is recommended in patients transplanted for HBV-related disease. The risk of HBV reactivation is due to persistence of covalently closed circular (ccc) DNA in hepatocytes.
Laura Tariciotti, Tariciotti, L, Ciotti, M, Ilaria Lenci, Carlo Federico Perno, Tisone, G, Giuseppe Tisone, Marco Ciotti, Perno, CF, Guenci, T, TISONE, GIUSEPPE, PERNO, CARLO FEDERICO, Daniele Di Paolo, Angelico, M, Fabio Marcuccilli, Tania Guenci, Mario Angelico, ANGELICO, MARIO, Di Paolo, D, Lenci, I, Marcuccilli, F   +20 more
core   +1 more source

Toward a Functional Cure for Chronic Hepatitis B: Current Landscape and Future Directions in Japan

Hepatology Research, Volume 56, Issue 6, Page 903-913, June 2026.
Hepatitis B is a viral liver infection that can become chronic, increasing the risk of developing liver cancer and liver failure. Because current treatments rarely cure these problems, researchers are now focusing on a functional cure in which the virus becomes undetectable in blood and stays that way, even after the treatment ends.
Yutaka Handa, Ethan Yichen Lee, Yasuhito Tanaka   +2 more
wiley   +1 more source

Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance

, 2014
Covalently closed circular DNA (cccDNA) is the transcriptional template of hepatitis B virus (HBV). Extensive research over the past decades has unveiled the important role of cccDNA in the natural history and antiviral treatment of chronic HBV infection.
Jia-Horng Kao, Hung-Chih Yang
core   +2 more sources

Association between intrahepatic cccDNA and the severity of liver inflammation in chronic hepatitis B virus infection patients

Frontiers in Medicine
Background and aimsThis research aimed to examine the association between hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) and liver inflammation in chronic hepatitis B (CHB) infection patients.MethodsFrom August 2013 to June 2022, CHB ...
Suxian Zhao, Chen Dong, Chudi Chang, Jiaming Zhang, Jing Li, Xiaoxiao Zhang, Weiguang Ren, Ying Zhang, Yuemin Nan   +8 more
doaj   +1 more source

Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in US Individuals With Chronic Hepatitis B Virus Infection

Journal of Viral Hepatitis, Volume 33, Issue 6, June 2026.
ABSTRACT Hepatitis B surface antigen (HBsAg) loss is associated with improved clinical outcomes in patients with chronic hepatitis B virus (HBV) infection based on studies predominantly in Asian populations. We assessed real‐world associations between HBsAg loss and long‐term clinical outcomes in a diverse US population with chronic HBV infection. This
Myriam Drysdale, Rose Chang, Shuang Wang, Anna Coutinho, Vera Gielen, Theo Man, Rui Song, Mei Sheng Duh, Mandana Khalili, Dickens Theodore   +9 more
wiley   +1 more source

Targeting Hepatitis B Virus With CRISPR/Cas9

Molecular Therapy: Nucleic Acids, 2014
Hepatitis B virus persistence in infected hepatocytes is due to the presence of covalently closed circular DNA (cccDNA), the template for the transcription of viral RNAs.
Christoph Seeger, Ji A Sohn
doaj   +1 more source

Analyses of HBV cccDNA quantification and modification.

, 2016
Covalently closed circular DNA (cccDNA) serves as the transcriptional template of hepatitis B virus (HBV) replication in the nucleus of infected cells. It ensures the persistence of HBV even if replication is blocked.
Protzer, U., Ulrike Protzer, Xia, Y., Stadler, D., Daniela Stadler, Yuchen Xia, Chunkyu Ko, Ko, C.   +7 more
core   +2 more sources

Chronic hepatitis B virus persistence: Mechanisms, consequences and implications for achieving cure

Annals of Hepatology
HBV persists within the hepatocyte due to the presence of intranuclear covalently closed circular DNA (cccDNA) and double-stranded linear DNA (dslDNA) integration. These bodies pose formidable challenges for achieving HBV functional and sterilizing cure.
Christopher Georgi, Simmone D’Souza, Carla Osiowy, Carla S. Coffin, Curtis L. Cooper   +4 more
doaj   +1 more source

Effects of entecavir on hepatitis B virus covalently closed circular DNA in hepatitis B e antigen-positive patients with hepatitis B.

PLoS ONE, 2015
The aim of this study was to assess the effect of 48-week entecavir therapy on serum and intrahepatic hepatitis B virus, covalently closed circular DNA (HBV cccDNA) levels in hepatitis B e antigen (HBeAg)-positive patients.
Ming Shi, Wan-Li Sun, Yan-Yan Hua, Bo Han, Long Shi   +4 more
doaj   +1 more source

Hepatitis B Virus Capsid: The Core in Productive Entry and Covalently Closed Circular DNA Formation

, 2023
Hepatitis B virus (HBV) relies on the core protein (HBc) to establish productive infection, as defined by the formation of the covalently closed circularized DNA (cccDNA), as well as to carry out almost every step of the lifecycle following cccDNA ...
Jianming Hu, Megan A. Mendenhall, Xupeng Hong   +2 more
core   +1 more source