Results 81 to 90 of about 2,847,915 (169)

Regulation of Hepatitis B virus Replication by Epigenetic Mechanisms and MicroRNAs

Frontiers in Genetics, 2013
The hepatitis B virus (HBV) genome forms a covalently closed circular DNA (cccDNA) minichromosome that persists in the nucleus of virus-infected hepatocytes.
Xiaoyong eZhang, Xiaoyong eZhang, Jinlin eHou, Mengji eLu   +3 more
doaj   +1 more source

Roles of the Envelope Proteins in the Amplification of Covalently Closed Circular DNA and Completion of Synthesis of the Plus-Strand DNA in Hepatitis B Virus

, 2011
Covalently closed circular DNA (cccDNA), the nuclear form of hepatitis B virus (HBV), is synthesized by repair of the relaxed circular (RC) DNA genome.
Thomas B. Lentz, Daniel D. Loeb
core   +1 more source

Screening for inhibitor of episomal DNA identified dicumarol as a hepatitis B virus inhibitor.

PLoS ONE, 2019
Currently, there is no available therapy to eradicate hepatitis B virus (HBV) in chronically infected individuals. This is due to the difficulty in eliminating viral covalently closed circular (ccc) DNA, which is central to the gene expression and ...
Fumihiko Takeuchi, Sotaro Ikeda, Yuta Tsukamoto, Yoshikazu Iwasawa, Chen Qihao, Yukie Otakaki, Ouda Ryota, Wan-Ling Yao, Ryo Narita, Hijikata Makoto, Koichi Watashi, Takaji Wakita, Koh Takeuchi, Kazuaki Chayama, Amane Kogure, Hiroki Kato, Takashi Fujita   +16 more
doaj   +1 more source

Quantification of Hepatitis B Virus Covalently Closed Circular DNA in Infected Cell Culture Models by Quantitative PCR

Bio-Protocol, 2019
Persistence of the human hepatitis B virus (HBV) requires the maintenance of covalently closed circular (ccc)DNA, the episomal genome reservoir in nuclei of infected hepatocytes.
Bingqian Qu, Stephan Urban
doaj   +1 more source

Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection

, 2004
BACKGROUND: In a recent study we demonstrated that serum covalently closed circular (ccc) hepatitis B virus (HBV) DNA is present in 93% of HBeAg-positive patients and that it correlates well with intrahepatic cccDNA (r=0.52, p=O.O04)(Wong DKH et al ...
Yuan, H, Wong, BCY, Yuen, RMF, Sum, SM, Chan, OO, Lai, CL, Wong, DKH, Yuen, JCH   +7 more
core   +1 more source

Prediction of cccDNA dynamics in hepatitis B patients by a combination of serum surrogate markers.

PLoS Computational Biology
Quantification of intrahepatic covalently closed circular DNA (cccDNA) is a key for evaluating an elimination of hepatitis B virus (HBV) in infected patients.
Kwang Su Kim, Masashi Iwamoto, Kosaku Kitagawa, Hyeongki Park, Sanae Hayashi, Senko Tsukuda, Takeshi Matsui, Masanori Atsukawa, Kentaro Matsuura, Natthaya Chuaypen, Pisit Tangkijvanich, Lena Allweiss, Takara Nishiyama, Naotoshi Nakamura, Yasuhisa Fujita, Eiryo Kawakami, Shinji Nakaoka, Masamichi Muramatsu, Kazuyuki Aihara, Takaji Wakita, Alan S Perelson, Maura Dandri, Koichi Watashi, Shingo Iwami, Yasuhito Tanaka   +24 more
doaj   +1 more source

Arsenic trioxide impacts hepatitis B virus core nuclear localization and efficiently interferes with HBV infection

Microbiology Spectrum
The key to a curative treatment of hepatitis B virus (HBV) infection is the eradication of the intranuclear episomal covalently closed circular DNA (cccDNA), the stable persistence reservoir of HBV.
Samuel Hofmann, Julius Luther, Verena Plank, Andreas Oswald, Julia Mai, Ilka Simons, Julija Miller, Valeria Falcone, Lea Hansen-Palmus, Hartmut Hengel, Michael Nassal, Ulrike Protzer, Sabrina Schreiner   +12 more
doaj   +1 more source

HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome

Advanced Science
Persistent transcription of HBV covalently closed circular DNA (cccDNA) is critical for chronic HBV infection. Silencing cccDNA transcription through epigenetic mechanisms offers an effective strategy to control HBV.
YiPing Qin, JiHua Ren, HaiBo Yu, Xin He, ShengTao Cheng, WeiXian Chen, Zhen Yang, FengMing Sun, ChunDuo Wang, SiYu Yuan, Peng Chen, DaiQing Wu, Fang Ren, AiLong Huang, Juan Chen   +14 more
doaj   +1 more source

Hepatitis B virus core-related antigen as a surrogate marker for covalently closed circular DNA

, 2016
BACKGROUND: Hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key to viral persistence in chronic hepatitis B patients. We aimed to explore whether serum hepatitis B core-related antigen (HBcrAg) could be a surrogate marker for ...
Fung, JYY, Cheung, KSM, Yuen, RMF, Lai, CL, Wong, DKH, Seto, WKW, Huang, FY, Yuen, MF   +7 more
core   +1 more source

Covalently closed-circular hepatitis B virus DNA reduction with entecavir or lamivudine

, 2015
AIM: To investigate the reduction in hepatitis B virus (HBV) covalently closed-circular DNA (cccDNA) with entecavir (ETV) or lamivudine (LAM). METHODS: This analysis included patients who had participated in the randomized Phase.
Yu, M, Locarnini, S, Scott Bowden, You-Chen Chao, Miao Yu, Llamoso, C, Stephen Locarnini, Ting-Tsung Chang, Robert A de Man, Gish, RG, Bowden, S, Han, KH, Tang, Hui, Cyril Llamoso, de Man, Rob, Robert G Gish, Hong Tang, Chao, YC, Chang, TT, Kwang-Hyub Han   +19 more
core   +1 more source