Results 181 to 190 of about 338,185 (301)

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

Temporal evolution of digital health communication in Rheumatoid Arthritis: A longitudinal NLP analysis of reddit discussions (2018-2024). [PDF]

PLoS One
Patel N, Sharma R, Lingasamy P, Sundararajan V, S SL, Modhukur V.   +5 more
europepmc   +1 more source

Repurposing Drugs for the Treatment of COVID-19

Journal of Biotechnology and Bioindustry, 2021
openaire   +2 more sources

Interpretability and Representability of Commutative Algebra, Algebraic Topology, and Topological Spectral Theory for Real‐World Data

Advanced Intelligent Discovery, EarlyView.
This article investigates how persistent homology, persistent Laplacians, and persistent commutative algebra reveal complementary geometric, topological, and algebraic invariants or signatures of real‐world data. By analyzing shapes, synthetic complexes, fullerenes, and biomolecules, the article shows how these mathematical frameworks enhance ...
Yiming Ren, Guo‐Wei Wei
wiley   +1 more source

Smart Denture with Embedded Thin‐Film Temperature Sensors Patterned by Femtosecond Laser Pulse for Elderly Healthcare

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
We demonstrate the direct‐laser patterning of a gold thin film on polymethyl methacrylate to fabricate a temperature sensor for dentures. The temperature sensor‐embedded smart dentures are evaluated in an oral environment, enabling in‐situ monitoring for elderly healthcare.
Han Ku Nam, Yong Kwon Chae, Seoung‐Jin Hong, Younggen Lee, Dongwook Yang, Byunggi Kim, Sang Wook Kang, Young‐Jin Kim   +7 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Analysis of molecular mechanism of Chinese medicine Jinhong decoction (JHD) in synergistically treating sepsis and COVID-19 based on network pharmacology. [PDF]

PLoS One
Fan J, Yang Y, Zhang F, Wu X, Li J, Liang L, Tang Q, Yan B, Zhang J, Pan X, Jin G, Wei C, Han P, He Y.   +13 more
europepmc   +1 more source

Commentary: No-test medication abortion: A sample protocol for increasing access during a pandemic and beyond. [PDF]

, 2020
Atrio, Jessica M, Coplon, Leah, Creinin, Mitchell D, Dean, Gillian, Gold, Marji, Grossman, Daniel, Mark, Alice, Perritt, Jamila, Raymond, Elizabeth G, Taylor, DeShawn, Upadhyay, Ushma D   +10 more
core   +1 more source

Structural problems without structural solutions? Youth leaders' perceptions of their community

American Journal of Community Psychology, EarlyView.
Abstract As young people explore and reflect on the conditions of their neighborhoods and communities, they can forge a critical consciousness—merging their perspectives and analysis to direct both individual and collective actions. Photovoice is a methodological tool that allows participants to document their perspectives and analysis and discuss with
Linnea L. Hjelm, Aishia A. Brown, Benjamin W. Fisher, Alice Story, Nubia Bennett   +4 more
wiley   +1 more source

Time-varying characteristics of remdesivir-treated patients hospitalised due to COVID-19: an electronic health record study. [PDF]

J Glob Health
Hoe JK, Blond K, Jimenez-Solem E, Berry M, Chiang M, Ankarfeldt MZ, Petersen J.   +6 more
europepmc   +1 more source