Results 201 to 210 of about 299,239 (347)

PIM1 Attenuates Innate Immunity to Foster Coronavirus Replication through Ubiquitin Ligase β‐TrCP‐Mediated IFNAR1 Degradation

Advanced Science, EarlyView.
Hijacking Host Kinase PIM1: A β‐Coronavirus (OC43) strategy to degrade IFNAR1 and evade antiviral immunity. Human β‐coronaviruses (OC43) exploit the proto‐oncoprotein PIM1 kinase to sabotage innate immunity. Viral RNA/proteins upregulate PIM1, which phosphorylates E3 ligase β‐TrCP1.
Qianya Wan, Lin Zhu, Cien Chen, Li Zhong, Houying Leung, Wei Li, Chang Xu, Xi Yao, Huan Hu, Mandi Wu, Yuxin Hou, Hin Chu, Yiran Wang, Sheng Chen, Mingyu Pan, Zongwei Cai, Ming‐liang He   +16 more
wiley   +1 more source

Antidepressant drug treatment protecting from COVID-19: one more piece in the repurposing puzzle [PDF]

, 2021
Julia Stingl
openalex   +1 more source

Phenylmethimazole is a candidate drug for the treatment of severe forms of coronavirus disease 2019 (COVID-19) as well as other virus-induced “cytokines storm”

, 2020
Cesidio Giuliani, Ines Bucci, Giorgio Napolitano   +2 more
openalex   +1 more source

Repurposing clinically approved drugs for COVID-19 treatment targeting SARS-CoV-2 papain-like protease

, 2021
Yunxia Xu, Ke Chen, Juanli Pan, Yingshou Lei, Danting Zhang, Lipei Fang, Jinle Tang, Xin Chen, Yanhong Ma, Yi Zheng, Zhang Bao, Yaoqi Zhou, Jian Zhan, Wei Xü   +13 more
openalex   +1 more source

USP8‐Governed MDA5 Homeostasis Promotes Innate Immunity and Autoimmunity

Advanced Science, EarlyView.
This study reveals that USP8 stabilizes MDA5 via AKT‐mediated phosphorylation (Ser718), enhancing their interaction and MDA5 deubiquitination. USP8 inactivation degrades MDA5, suppressing type I IFN and cytokine production. Pharmacological inhibition of USP8/AKT alleviates MDA5‐driven autoimmunity, demonstrating the USP8‐MDA5 axis as a therapeutic ...
Qimin Zhang, Shan Huang, Yan He, Weiwei Wang, Chao Tong, Mengru Ma, Manyu Zhao, Lian Yi, Klaus‐Peter Knobeloch, Peijing Zhang   +9 more
wiley   +1 more source

Theoretical Prediction of Possible Drug Treatment of COVID-19 using Coumarins Containing Chloroquine Moeity

, 2020
Ammar A. Ibrahim, Omar Yahya, Mohammed Auwal Ibrahim   +2 more
openalex   +1 more source

Immune dysfunction in COVID-19 and judicious use of antirheumatic drugs for the treatment of hyperinflammation

, 2021
Abdurrahman Tufan, Marco Matucci‐Cerinic   +1 more
openalex   +2 more sources

Targeting Neutrophil/Eosinophil Extracellular Traps by Aptamer‐Functionalized Nanosheets to Overcome Recalcitrant Inflammatory Disorders

Advanced Science, EarlyView.
In this study, C‐TAH, as multifunctional nanosheets, is developed with tannic acid and histone aptamer coverage. C‐TAH displays mild cytotoxicity, robust dsDNA and NETs/EETs binding efficiency, and potent antioxidant and antibacterial ability in vitro. C‐TAH treatment ameliorates dysregulated inflammation and restores hearing function in animal models,
Yongqiang Xiao, Xinyue Wang, Ming Liu, Xiao Fu, Nanfeng Zhang, Wenqing Yang, Junyi Ge, Yangyang Li, Duan Ma, Jing Ma, Weiping Wen, Dongdong Ren, Tianyu Zhang, Zhaoxu Tu   +13 more
wiley   +1 more source

Current Approaches and Challenges in Advanced Oxidation Processes for Nanoplastic Degradation

Advanced Science, EarlyView.
This review explores recent progress in advanced oxidation processes (AOPs) for the degradation of nanoplastics (NPs) in water. It presents a comparative assessment of key AOP technologies and identifies current limitations in analytical methods and treatment efficiency.
Arezou Fazli, Athanassia Athanassiou, Despina Fragouli   +2 more
wiley   +1 more source

A Review of Repurposed Cancer Drugs in Clinical Trials for Potential Treatment of COVID-19

, 2021
Bárbara Costa, Nuno Vale
openalex   +1 more source