Results 221 to 230 of about 344,100 (302)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

How Can Pharmacology Help Us Overcome the Challenges of Drug Repositioning as Antivirals to Treat Emerging Pathogens? The Example of Covid-19. [PDF]

Clin Transl Sci
Ben Ghezala I, Peiffer-Smadja N, Solas C, Nougairède A, Touret F, Bardou M.   +5 more
europepmc   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Variations in the perceived value of anti-SARS-CoV-2 therapeutics based on physicians' clinical backgrounds. [PDF]

Sci Rep
Hagiwara A, Komiya K, Shindo Y, Takamatsu K, Nishimura N, Takechi Y, Ichihara E, Takazono T, Izumi S, Gotoh S, Sakao S, Izumo T, Yamamoto K, Yatera K, Kakeya H, Shibata Y, Tomii K, Sagara H, Sasaki Y, Hirai T, Yokoyama A, Mukae H, Ogura T.   +22 more
europepmc   +1 more source

COVID-19: Top 60 Drug Treatments in Development

Genetic Engineering & Biotechnology News, 2020
openaire   +2 more sources

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Inhalation: A Smart Strategy and Increasing Potential for Drug Delivery. [PDF]

Drug Des Devel Ther
Wang SC, Kuo TH, Rai CI, Chen YC.
europepmc   +1 more source

Implementation of malaria control programmes during the COVID-19 pandemic in the Southern African Development Community Elimination 8 countries: A scoping review. [PDF]

Afr J Prim Health Care Fam Med
Muzamhindo DN, Chironda G, Tsoka-Gwegweni JM.   +2 more
europepmc   +1 more source

Lost learning: Prevalence, inequalities and outcomes of internal exclusion in mainstream secondary schools

British Educational Research Journal, EarlyView.
Abstract Internal exclusion (isolation) is a behaviour management approach involving the temporary relocation of a pupil from their classroom to a designated isolation space as a consequence of disruptive behaviour. We present the first study of prevalence (i.e., what proportion of young people are isolated?), inequalities (i.e., who is more likely to ...
Emma Thornton, Qiqi Cheng, Ola Demkowicz, Neil Humphrey   +3 more
wiley   +1 more source

Analysis of molecular mechanism of Chinese medicine Jinhong decoction (JHD) in synergistically treating sepsis and COVID-19 based on network pharmacology. [PDF]

PLoS One
Fan J, Yang Y, Zhang F, Wu X, Li J, Liang L, Tang Q, Yan B, Zhang J, Pan X, Jin G, Wei C, Han P, He Y.   +13 more
europepmc   +1 more source