Results 231 to 240 of about 231,281 (308)

Long‐Term Trends in Cardiac Erosion After Transcatheter Closure of Atrial Septal Defects With the Amplatzer Septal Occluder

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Trends in cardiac erosion after closure of secundum atrial septal defects (ASD) with the Amplatzer Septal Occluder (ASO) have not been assessed since updates were made to the Instructions for Use in 2012 and 2018. This study evaluates the incidence and demographics of ASO erosion over time since its introduction in 1996.
Daniel S. Levi, Doff B. McElhinney
wiley   +1 more source

Optimizing drug combinations to resurrect the potency of failed antibody therapy against emerging COVID-19 variants using IDentif.AI. [PDF]

Front Digit Health
Wang P, You K, Chia ZW, Hooi L, Chong LM, Chye H, Moh A, Lee ZY, Lim E, Kok AZX, Chua S, Zhuang I, Chang E, Tan BH, Tan GGY, Vasoo S, Chan CEZ, Chow EK, Ho D.   +18 more
europepmc   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Retrospective Drug Utilization Pattern of the Use of Antivirals and Its Outcome in Hospitalized COVID-19 Patients in a Tertiary Care Hospital in Mumbai From July to October 2020. [PDF]

Cureus
Marolia KR, Nerurkar RP.
europepmc   +1 more source

PERFECTA Loaded Lipid Cubosomes for 19F‐MRI: Physico‐Chemical Characterization

Chemistry – A European Journal, EarlyView.
Phytantriol‐based cubosomes loaded with PERFCTA, a fluorinated MRI probe, were developed as promising systems for imaging and drug delivery. The nanoparticles showed high PERFECTA encapsulation efficiency, strong fluorine MRI signals, and optimal colloidal stability in biological media.
Pietro Milesi, Beatrice Lucia Bona, Cristina Chirizzi, Marco Campanile, Pompea Del Vecchio, Marc Schmutz, Valerie Sartor, Debora Berti, Pierangelo Metrangolo, Francesca Baldelli Bombelli, Barbara Lonetti   +10 more
wiley   +1 more source

Erratum: NNZ-2591 in Children and Adolescents With Phelan-McDermid Syndrome: Single-Group, Open-Label, Phase 2 Trial Results. [PDF]

Neurol Genet
Neumeyer AM, Srivastava S, Holder JL, Milad MA, Squires L, Jones NE, Glass L, Berry-Kravis E.   +7 more
europepmc   +1 more source

Substrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates

Chemistry – A European Journal, EarlyView.
The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.
Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz   +13 more
wiley   +1 more source

Antivirals Targeting Coronavirus RNA-Dependent RNA Polymerase and Main Protease: From Mechanisms of Action to Outcomes in COVID-19 Clinical Trials. [PDF]

Microb Biotechnol
Brüssow H.
europepmc   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Acute pancreatitis temporally associated with COVID-19 pneumonia in a patient with post-tuberculosis chronic pulmonary aspergillosis: a case report. [PDF]

Front Med (Lausanne)
Yu W, Yang P, Ding M, Guo L, Liu Y, Zhou D, Gu C.   +6 more
europepmc   +1 more source