Results 51 to 60 of about 11,245 (224)

Detection of Vaccinia Virus in Urban Domestic Cats, Brazil

Emerging Infectious Diseases, 2017
We investigated possible vaccinia virus (VACV) in urban house cats in Brazil. Serum samples from 6 cats were positive for VACV by PCR, indicating likely VACV circulation among house cats in urban areas of Brazil. This finding highlights the importance of
Galileu Barbosa Costa, Júlia Bahia Miranda, Gregório Guilherme Almeida, Jaqueline Silva de Oliveira, Mariana Siqueira Pinheiro, Stefanne Aparecida Gonçalves, Jenner Karlisson Pimenta dos Reis, Ricardo Gonçalves, Paulo César Peregrino Ferreira, Cláudio Antônio Bonjardim, Jônatas Santos Abrahão, Maurício Teixeira Lima, Giliane de Souza Trindade   +12 more
doaj   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

Effects of nasal or pulmonary delivered treatments with an adenovirus vectored interferon (mDEF201) on respiratory and systemic infections in mice caused by cowpox and vaccinia viruses. [PDF]

PLoS ONE, 2013
An adenovirus 5 vector encoding for mouse interferon alpha, subtype 5 (mDEF201) was evaluated for efficacy against lethal cowpox (Brighton strain) and vaccinia (WR strain) virus respiratory and systemic infections in mice.
Donald F Smee, Min-Hui Wong, Brett L Hurst, Jane Ennis, Jeffrey D Turner   +4 more
doaj   +1 more source

Increasing protectivity of the smallpox vaccine

Медицинская иммунология, 2022
At the present time, vast majority of human population lacks immunity against orthopoxvirus infections caused by variola (smallpox), monkeypox, cowpox, or buffalopox viruses.
S. N. Shchelkunov, A. A. Sergeev, K. A. Titova, S. A. Pyankov, S. N. Yakubitskiy   +4 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

INTERSECTORAL INTEGRATION AS A STRATEGY TO ADDRESS A HUMAN COWPOX OUTBREAK IN THE AGRESTE REGION OF PERNAMBUCO

Brazilian Journal of Infectious Diseases
Introduction: Cowpox is a zoonosis caused by viruses of the Orthopoxvirus genus, with increasing incidence in humans over recent years. Educational campaigns targeting rural populations, especially cattle farmers, are necessary to promote prevention and ...
Elane Rafaella Cordeiro Nunes Serafim, Juliana Ramos Santos, Maria da Conceição de Santana, Izeni Teixeira Pimentel   +3 more
doaj   +1 more source

From the animal house to the field : are there consistent individual differences in immunological profile in wild populations of field voles (Microtus agrestis)? [PDF]

, 2017
Inbred mouse strains, living in simple laboratory environments far removed from nature, have been shown to vary consistently in their immune response.
A Gelman, AC Darby, AJ Caton, AJ Gibson, AK Abbas, AK Turner, AK Turner, AL Benjamin, AL Graham, AL Graham, AM Ahmed, B Flahou, BT Seet, CE Johnston, CJ Downs, D Alzhanova, DM Buehler, E Kluen, E Sild, Elena Arriero, EM Eugui, IG Sakala, J Behnke, JA Jackson, JA Jackson, JA Stamps, Janette E. Bradley, JD Hadfield, JE Bradley, Joseph A. Jackson, KD Matson, KJ Bown, Klara M. Wanelik, L Debeffe, Matthew C. Fisher, Mike Begon, NJ Dingemanse, P Kidd, PL Earl, Richard J. Birtles, RS Sellers, S Burthe, S Stearns, S Telfer, SC Patrick, SL Reiner, Steve Paterson, W Liang   +47 more
core   +6 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Recurrent Respiratory Papillomatosis Foundation Position Statement on the Management of Adults With RRP

The Laryngoscope, EarlyView.
ABSTRACT Objective With regulatory approval of HPV‐specific immunotherapy for recurrent respiratory papillomatosis (RRP) and growing experience with systemic bevacizumab, a management algorithm incorporating these medical treatments is warranted. Data Sources and Methods RRP Foundation (RRPF) Key Opinion Leaders offer a proposed management algorithm ...
Simon R. Best, Aaron D. Friedman, Clark A. Rosen, Robert T. Sataloff, Laura A. Matrka, H. Steven Sims, David E. Rosow, Nabil F. Saba, David G. Lott, Adam M. Klein, Ted Mau, Milan R. Amin, Kathryn A. Wikenheiser‐Brokamp, Scott M. Norberg, Kim McClellan, Geoffrey D. Young, Clint T. Allen, on behalf of the Recurrent Respiratory Papillomatosis Foundation   +17 more
wiley   +1 more source

Flow Cytometry and T-Cell Response Monitoring after Smallpox Vaccination

Emerging Infectious Diseases, 2003
Orthopoxvirus zoonosis or smallpox as result of bioterrorism or biological warfare represents a risk for epidemic spread. By monitoring T-cell responses by flow cytometry, we observed a recall response after recent vaccination against smallpox.
Fabrizio Poccia, Cristiana Gioia, Carla Montesano, Federico Martini, Douglas Horejsh, Concetta Castilletti, Leopoldo Paolo Pucillo, Maria Rosaria Capobianchi, Giuseppe Ippolito   +8 more
doaj   +1 more source