Results 61 to 70 of about 12,038 (266)

Increasing protectivity of the smallpox vaccine

Медицинская иммунология, 2022
At the present time, vast majority of human population lacks immunity against orthopoxvirus infections caused by variola (smallpox), monkeypox, cowpox, or buffalopox viruses.
S. N. Shchelkunov, A. A. Sergeev, K. A. Titova, S. A. Pyankov, S. N. Yakubitskiy   +4 more
doaj   +1 more source

Immunity in society: diverse solutions to common problems [PDF]

, 2012
Understanding how organisms fight infection has been a central focus of scientific research and medicine for the past couple of centuries, and a perennial object of trial and error by humans trying to mitigate the burden of disease.
Babayan, S.A., Schneider, D.S.
core   +3 more sources

AIEgen‐Based Proactive Early Warning System and Precise Treatment Strategy for Monkeypox Prevention and Control

Advanced Science, EarlyView.
An intelligent early warning and treatment system for monkeypox, utilizing a sprayable AIEgen‐ liquid dressing (AIE@LD) that responds to lesion pH. Integrated with a smartphone app and cloud platform, it enables real‐time infection detection via fluorescence imaging and triggers on‐demand photodynamic therapy under white light, effectively eradicating ...
Wei Wang, Zining Liu, Mengjun Li, Judun Zheng, Ruilin Zhang, Ke Liu, Xiaoxue Li, Shaoying Wen, Jingze Yu, Meijia Pan, Fengbo Ma, Kun Zhou, Zheng Zhao, Chenguang Shen, Yuhui Liao   +14 more
wiley   +1 more source

Exceptional Clinical Resistance and Variable Reservoir Competence [PDF]

, 2018
Cowpox virus (CPXV) is a zoonotic virus and endemic in wild rodent populations in Eurasia. Serological surveys in Europe have reported high prevalence in different vole and mouse species.
Beer, Martin, Franke, Annika, Hoffmann, Donata, Keller, Markus, Osterrieder, Nikolaus, Ulrich, Rainer G., Weber, Saskia   +6 more
core   +1 more source

Eczema Monkeypoxicum Following Sexual Transmission Treated With Tecovirimat

JEADV Clinical Practice, EarlyView.
ABSTRACT Mpox is a zoonotic viral infection caused by monkeypox virus (MPXV) and risk factors for its dissemination include previous dermatoses such as atopic dermatitis [1]. We present the case of a 30‐year‐old male with an unusual and extensive presentation of mpox following unprotected sexual intercourse, with an excellent response to tecovirimat ...
Andrés Vidal González, Sergio López Alcázar, José Ángel Amat Sánchez, Francisco Vergara Barria, Rosa Feltes Ochoa, Elena Sendagorta Cudos, Pedro Herranz Pinto   +6 more
wiley   +1 more source

Poxvirus-encoded TNF decoy receptors inhibit the biological activity of transmembrane TNF [PDF]

, 2015
© 2015 The Authors. Poxviruses encode up to four different soluble TNF receptors, named cytokine response modifier B (CrmB), CrmC, CrmD and CrmE. These proteins mimic the extracellular domain of the cellular TNF receptors to bind and inhibit the activity
Alcamí, Antonio, Alejo, Alí, Pontejo, Sergio M.   +2 more
core   +1 more source

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, EarlyView.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Flow Cytometry and T-Cell Response Monitoring after Smallpox Vaccination

Emerging Infectious Diseases, 2003
Orthopoxvirus zoonosis or smallpox as result of bioterrorism or biological warfare represents a risk for epidemic spread. By monitoring T-cell responses by flow cytometry, we observed a recall response after recent vaccination against smallpox.
Fabrizio Poccia, Cristiana Gioia, Carla Montesano, Federico Martini, Douglas Horejsh, Concetta Castilletti, Leopoldo Paolo Pucillo, Maria Rosaria Capobianchi, Giuseppe Ippolito   +8 more
doaj   +1 more source

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]

, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O, De Motes, C M, Ember, S W J, Ferguson, B J, Mazzon, M, Smith, G L, Sumner, R P   +6 more
core   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source