Results 81 to 90 of about 9,882 (215)
Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +1 more source
Human Cyclophilins—An Emerging Class of Drug Targets
Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova +3 more
wiley +1 more source
A vaccinia virus renaissance
Human Vaccines & Immunotherapeutics, 2012 In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus).
Paulo H. Verardi +2 more
doaj +1 more source
Sex Differences in Response to Viral Vector Vaccines—Implications for Future Vaccine Design
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Vaccination represents one of the most impactful public health achievements, preventing 3.5 to 5 million deaths annually according to estimates of the World Health Organization. Yet, recent outbreaks of emerging and reemerging infectious diseases highlight the need for rapid and strategic vaccine development using vaccine platforms ...
Ilka Grewe +2 more
wiley +1 more source
Spatial analyses of wildlife contact networks [PDF]
, 2015 We thank Kathy Horadam for useful discussions about the graph dissimilarity measures and Meggan Craft for reading an early draft of the manuscript and for her helpful advice and encouragement.Peer reviewedPublisher ...
Abbasi, Babak +4 more
core +1 more source
Journal of Internal Medicine, Volume 299, Issue 3, Page 328-348, March 2026.Abstract The etiology of Alzheimer's disease (AD) remains under active debate. In this perspective, we explore the hypothesis that a primarily infection‐caused chronic dysregulation and weakening of human innate immunity via the underexpression, degradation, and inactivation of innate immune proteins necessary for direct antimicrobial effects and ...
Annelise E. Barron +3 more
wiley +1 more source
Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy
Cancer Medicine, Volume 15, Issue 2, February 2026.ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li +13 more
wiley +1 more source
Veterinary Research, 2011 Transmission from pet rats and cats to humans as well as severe infection in felids and other animal species have recently drawn increasing attention to cowpox virus (CPXV).
Roth Swaantje J +5 more
doaj +1 more source
Vaccine Delivery Methods into the Future [PDF]
, 2016 Special Issue: Vaccine ...
Apostolopoulos, Vasso
core +2 more sources
MedComm, Volume 7, Issue 2, February 2026.We developed four candidate mRNA vaccine antigens based on conserved sequences of MPXV A35R and M1R proteins. Our findings demonstrate that the MV2 vaccine possesses favorable immunogenicity and prophylactic potential against MPXV and VACV infections, positioning it as a promising clinical candidate for MPXV prevention.
Cong Tang +14 more
wiley +1 more source