Results 81 to 90 of about 10,268 (259)
The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations
Acta Paediatrica, EarlyView.ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley +1 more source
Incongruencies in Vaccinia Virus Phylogenetic Trees
Computation, 2014 Over the years, as more complete poxvirus genomes have been sequenced, phylogenetic studies of these viruses have become more prevalent. In general, the results show similar relationships between the poxvirus species; however, some inconsistencies are ...
Chad Smithson +3 more
doaj +1 more source
Variola virus in a 300-year-old Siberian mummy. [PDF]
, 2012 International audienceNo abstract ...
Alekseev, Anatoly N +14 more
core +2 more sources
Treatment of Vaccinia and Cowpox Virus Infections in Mice with CMX001 and ST-246
Viruses, 2010 Although a large number of compounds have been identified with antiviral activity against orthopoxviruses in tissue culture systems, it is highly preferred that these compounds have activity in vivo before they can be seriously considered for further ...
Earl R. Kern, Debra C. Quenelle
doaj +1 more source
Mpox and the Ethics of Outbreak Management: Lessons for Future Public Health Crises
Developing World Bioethics, EarlyView.ABSTRACT Mpox, first identified in captive monkeys in 1958 and recognized in humans by 1970 in the Democratic Republic of Congo, was historically confined to sporadic zoonotic outbreaks in Central and West Africa. These outbreaks, often driven by rodent‐to‐human transmission in resource‐limited settings, reflect persistent systemic health disparities ...
Adetayo E. Obasa +3 more
wiley +1 more source
Orthopoxvirus Genome Evolution: The Role of Gene Loss
Viruses, 2010 Poxviruses are highly successful pathogens, known to infect a variety of hosts. The family Poxviridae includes Variola virus, the causative agent of smallpox, which has been eradicated as a public health threat but could potentially reemerge as a ...
Eneida L. Hatcher +3 more
doaj +1 more source
Sir Matthew Tierney and the foundation of the 1804 Sussex Vaccine Institution [PDF]
, 2019 Irish physician Sir Matthew John Tierney (1776–1845) was a vaccine pioneer who learnt the procedure directly from Edward Jenner in Gloucestershire. In 1802 Tierney completed an MD at Glasgow on vaccination and moved to Brighton, where he was appointed ...
Cooper, Maxwell +2 more
core +1 more source
Humoral epitope dominance and immune imprinting by SARS‐CoV‐1 and SARS‐CoV‐2 vaccines
Immunology &Cell Biology, EarlyView.We investigated Modified Vaccinia Ankara (MVA) vaccine candidates expressing the SARS‐CoV‐1 or SARS‐CoV‐2 Spike, as a primary or booster immunization, for their ability to induce antibodies targeting different epitopes on the SARS‐CoV‐2 RBD and broad cross‐reactive or cross‐neutralizing responses in C57BL/6 and antibody humanized (Ig‐humanized) mice ...
Deborah L Burnett +17 more
wiley +1 more source
A vaccinia virus renaissance
Human Vaccines & Immunotherapeutics, 2012 In 1796, Edward Jenner introduced the concept of vaccination with cowpox virus, an Orthopoxvirus within the family Poxviridae that elicits cross protective immunity against related orthopoxviruses, including smallpox virus (variola virus).
Paulo H. Verardi +2 more
doaj +1 more source