Results 1 to 10 of about 755,483 (324)
Medical Journal of Australia, 2000 Cyclooxygenase-2 (COX-2) inhibitors constitute a new group of non-steroidal anti-inflammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not by cyclooxygenase-1. Two COX-2 inhibitors are currently available in Australia--celecoxib, which is taken twice daily, and rofecoxib, which is taken once ...
Brooks, P. M., Day, R. O.
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The overexpression of COX 2 in Wilms’ tumor [PDF]
Reviews in Clinical Medicine, 2014 Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level ...
Sara Hashemi
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Cox-2 inhibition activities of creams containing anguilla bicolor and sea cucumbers extract on croton oil induced inflammation in mice [PDF]
Pharmaciana, 2020 The fatty acids, like EPA and DHA, were known as anti-inflammation. It works on inflammatory tissue, brought by edema plasma, and changed into resolvins, protectins, and maresins by the enzyme reaction. Anguilla bicolor and Sea cucumber fish are known to
Heru Sasongko +6 more
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Therapeutic Effects of Eugenol in Polycystic Ovarian Rats Induced by Estradiol Valerate: A Histopathological and A Biochemical Study [PDF]
International Journal of Fertility and Sterility, 2022 Background: Polycystic ovary syndrome (PCOS) is a common type of endocrinopathy in women which is accompaniedby androgens elevation, insulin resistance, and metabolic dysfunction.
Zahra Kokabiyan +3 more
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Viscum album-mediated COX-2 inhibition implicates destabilization of COX-2 mRNA. [PDF]
PLoS ONE, 2015 Extensive use of Viscum album (VA) preparations in the complementary therapy of cancer and in several other human pathologies has led to an increasing number of cellular and molecular approaches to explore the mechanisms of action of VA. We have recently
Chaitrali Saha +4 more
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Di-san junyi daxue xuebao, 2021 Objective To investigate the dynamic changes and the roles of COX-2 and its downstream factors in the carcinogenic process using a mouse model stably expressing hepatitis B virus X (HBx). Methods The expression of HBx in HBx-EGFP-14-19 cells was detected
WU Nan +7 more
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COX-2 as a potential biomarker and therapeutic target in melanoma
Cancer Biology & Medicine, 2020 With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an
Diana Valentina Tudor +7 more
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Polish Journal of Pathology, 2022 The pathogenesis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) differs according to whether prior treatment with interferon (IFN) vs. direct-acting antiviral agents (DAAs) was administered.
Dina Sweed +6 more
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Biology Open, 2020 Inflammation and proinflammatory cytokines have been implicated in the progression of benign prostatic hyperplasia (BPH). Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. Our previous study found that MIF is highly expressed in
Hualin Song, Qi Shen, Shuai Hu, Jie Jin
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Hidden Cardiotoxicity of Rofecoxib Can be Revealed in Experimental Models of Ischemia/Reperfusion
Cells, 2020 Cardiac adverse effects are among the leading causes of the discontinuation of clinical trials and the withdrawal of drugs from the market. The novel concept of ‘hidden cardiotoxicity’ is defined as cardiotoxicity of a drug that manifests in ...
Gábor B. Brenner +19 more
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