Results 1 to 10 of about 618,083 (188)
Viscum album-mediated COX-2 inhibition implicates destabilization of COX-2 mRNA. [PDF]
PLoS ONE, 2015 Extensive use of Viscum album (VA) preparations in the complementary therapy of cancer and in several other human pathologies has led to an increasing number of cellular and molecular approaches to explore the mechanisms of action of VA. We have recently
Chaitrali Saha +4 more
doaj +6 more sources
Experimental and Clinical Pharmacology: COX-2 inhibitors [PDF]
Australian Prescriber, 2000 There are two cyclo-oxygenase enzymes: COX-1 regulates physiological function in the gut and kidney, while COX-2 is induced in inflammation and repair. Selective COX-2 inhibitors are now available. In early clinical trials their efficacy in arthritis was equivalent to that of less selective non-steroidal anti-inflammatory drugs and they had a ...
Peter Brooks
openalex +4 more sources
Neuromuscular Polytrauma Pain is Resolved by Macrophage COX-2 Nanoimmunomodulation [PDF]
International Journal of NanomedicineIbdanelo Cortez,1,* Caitlyn M Gaffney,1,* Riddhi Vichare,2 Caitlin V Crelli,2 Lu Liu,2 Eric Lee,1 Jules Edralin,1 James M Nichols,1 Hoang Vu Pham,1 Syed Mehdi,1 Jelena M Janjic,2 Andrew J Shepherd1 1Laboratories of Neuroimmunology, Department of ...
Cortez I +11 more
doaj +2 more sources
Therapeutic Effects of Eugenol in Polycystic Ovarian Rats Induced by Estradiol Valerate: A Histopathological and A Biochemical Study [PDF]
International Journal of Fertility and Sterility, 2022 Background: Polycystic ovary syndrome (PCOS) is a common type of endocrinopathy in women which is accompaniedby androgens elevation, insulin resistance, and metabolic dysfunction.
Zahra Kokabiyan +3 more
doaj +1 more source
The overexpression of COX 2 in Wilms’ tumor [PDF]
Reviews in Clinical Medicine, 2014 Cyclooxygenase 2 has become an important pharmacological target in anticancer therapy due to the over expression of COX 2 in pathological conditions. Wilms’ tumor is a common kidney cancer in children which has shown an increase in COX 2 enzyme level ...
Sara Hashemi
doaj +3 more sources
Cox-2 inhibition activities of creams containing anguilla bicolor and sea cucumbers extract on croton oil induced inflammation in mice [PDF]
Pharmaciana, 2020 The fatty acids, like EPA and DHA, were known as anti-inflammation. It works on inflammatory tissue, brought by edema plasma, and changed into resolvins, protectins, and maresins by the enzyme reaction. Anguilla bicolor and Sea cucumber fish are known to
Heru Sasongko +6 more
doaj +1 more source
COX-2 as a potential biomarker and therapeutic target in melanoma
Cancer Biology & Medicine, 2020 With a constantly increasing incidence, cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic options. Melanoma is a model tumor in immuno-oncology. Inflammation represents an
Diana Valentina Tudor +7 more
doaj +1 more source
Biology Open, 2020 Inflammation and proinflammatory cytokines have been implicated in the progression of benign prostatic hyperplasia (BPH). Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine. Our previous study found that MIF is highly expressed in
Hualin Song, Qi Shen, Shuai Hu, Jie Jin
doaj +1 more source
Di-san junyi daxue xuebao, 2021 Objective To investigate the dynamic changes and the roles of COX-2 and its downstream factors in the carcinogenic process using a mouse model stably expressing hepatitis B virus X (HBx). Methods The expression of HBx in HBx-EGFP-14-19 cells was detected
WU Nan +7 more
doaj +1 more source
Polish Journal of Pathology, 2022 The pathogenesis of hepatitis C virus (HCV)-related hepatocellular carcinoma (HCC) differs according to whether prior treatment with interferon (IFN) vs. direct-acting antiviral agents (DAAs) was administered.
Dina Sweed +6 more
doaj +1 more source