Results 91 to 100 of about 757,334 (297)

Investigation of the Relationship between COX-2 Expression, Clinicopathological Symptoms, and Prognosis of the Patients with Gastric Cancer [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2023
Introduction: The present study was designed to investigate the relationship between COX-2 gene expression, clinicopathological symptoms, and prognosis of patients with gastric cancer.
Abolfazl Hekmat-Shoar, AmirAli Moodi Ghalibaf, Ali Shamshirian, MohammadReza Abbaszadegan4, Bahram Memar, Mohammad Reza Motie   +5 more
doaj  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Aynısafa Bitkisi (Calendula officinalis L.) Fitobileşenlerinin Siklooksijenaz-2 Enzimi Üzerine Etkisinin İn Siliko İncelenmesi

Wah Academia Journal of Health and Nutrition
Nonsteroidal antiiflamatuvar ilaçlar (NSAİİ), analjezik, antipiretik ve antiinflamatuvar etkiye sahip olup, siklooksijenaz – 2 (COX-2) enzim inhibisyonu yoluyla bu etkileri gösterdikleri belirlenmiştir.
Sevgi DURNA DAŞTAN, Şeyda KAYA, Sultan ERKAN, Taner DAŞTAN   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice [PDF]

, 2018
Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models.
Cózar Bernal, María José, González Rodríguez, María Luisa, Motilva Sánchez, Virginia, Rabasco Álvarez, Antonio María, Rodríguez Luna, Azahara María, Talero Barrientos, Elena Mª, Ávila Román, Francisco Javier   +6 more
core   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents. [PDF]

, 2008
Following our previous research on anti-inflammatory drugs (NSAIDs), we report here the synthesis of chiral 1,5-diarylpyrroles derivatives that were characterized for their in vitro inhibitory effects toward cyclooxygenase (COX) isozymes.
ANZELLOTTI P., ANZINI M., BIAVA M., BOTTA M., CIRILLI R., FERRETTI R., FORLI ., GALLINELLA B., GHELARDINI C., GIORDANI A., LA TORRE F., MAKOVEC F., MANETTI F., NORCINI M., PATRIGNANI P., PERGOLA C., POCE G., PORRETTA G. C., ROSSI, ANTONIETTA, SAUTEBIN, LIDIA, SUPINO S.   +20 more
core   +1 more source

Prognostic Impact of European LeukemiaNet Genetic Risk Stratification System in Adult Patients With Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
This study aimed to evaluate the prognostic value of ELN2017 in predicting survival outcomes and to assess the impact of clinical and molecular factors such as age, FLT3 and NPM1 mutations, and allogeneic hematopoietic stem cell transplantation (allo‐HSCT).
Mobina Shrestha, Bishwas Mandal, Vishal Mandal, Asis Shrestha, Amir Babu Shrestha   +4 more
wiley   +1 more source

COX-2 inhibitor [PDF]

Rheumatology, 2007
P C, Gøtzsche, N H, Bjarnason
openaire   +2 more sources

Cox-2 Inhibition Enhances the Activity of Sunitinib in Human Renal Cell Carcinoma Xenografts [PDF]

, 2013
Background: Sunitinib (Su), a tyrosine kinase inhibitor of VEGFR, is effective at producing tumour response in clear cell renal cell carcinoma (cRCC), but resistance to therapy is inevitable. As COX-2 is a known mediator of tumour growth, we explored the
Alsop, David C., Atkins, M B, Bahamon, B, Bhatt, Rupal Satish, Goldberg, S. Nahum, Mier, James W., O'Neill, A, Signoretti, Sabina, Wang, Xiaoen, Wood, C G, Zhang, L   +10 more
core   +1 more source