Results 211 to 220 of about 757,334 (297)

Targeting COX-2 to Alleviate Depressive Phenotypes: Etoricoxib's Antidepressant Effects in Chronic Unpredictable Mild Stress-Exposed Mice. [PDF]

Cureus
P S, K M, P S.
europepmc   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

COX-2 regulates IL-17A-producing γδ T cells to drive mismatch repair-deficient colon cancer

Suzuki T, White M, Leach J, Edwards J, Gilroy K, Porter R, Hong Y, Terradas-Terradas M, Hayman H, Mohamed NE, Lannagan T, Mackey J, Ridgway R, Campbell A, Verbandt S, Kirschner K, Tejpar S, Edwards J, Dunne P, Coffelt S, Sansom O.   +20 more
europepmc   +1 more source

Dual Inhibition of COX-2/5-LOX Through Novel Hybrids of NSAIDs and Peptides: Insights from Molecular Dynamics Simulation and Per-Residue Decomposition. [PDF]

ChemistryOpen
Jiménez-Cruz JC, Guzmán-Mejía R, Navarro-Santos P, García-Gutiérrez HA, Ontiveros-Rodríguez JC, Herrera-Bucio R, Cortés-Muñoz V, Aviña-Verduzco JA.   +7 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Dual COX-2 and EGFR inhibition by pyrazole-<i>ar</i>-turmerone hybrids suppresses colorectal cancer cell proliferation. [PDF]

RSC Med Chem
Sangsawat M, Nalinratana N, Chaichompoo W, Vajragupta O, Zhu H, Song Y, Thitikornpong W, Rojsitthisak P.   +7 more
europepmc   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

Retracted: Expression of p-Akt and COX-2 in Gastric Adenocarcinomas and Adenovirus Mediated Akt1 and COX-2 ShRNA Suppresses SGC-7901 Gastric Adenocarcinoma and U251 Glioma Cell <i>Growth In Vitro</i> and <i>In Vivo</i>. [PDF]

Technol Cancer Res Treat
europepmc   +1 more source

Reduced expression of UPF1 promotes tumor progression through stabilizing COX-2 mRNA in nasopharyngeal carcinoma. [PDF]

Front Immunol
Wu C, Xiao R, Zhang L, Chen Z, Zhang M, Li J, Zhou Y, Wang S, Jiang C, Wang H, Sun R, Mai S.   +11 more
europepmc   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source