Results 31 to 40 of about 755,483 (324)

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]

, 2016
In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay, Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James, Powell, Arfon G.M.T., Roseweir, Antonia K., Van Wyk, Hester C.   +7 more
core   +3 more sources

Pharmacodynamic and Pharmacokinetic Comparison between Selective and Non-selective COX-2 Inhibitors in Mice [PDF]

Journal of Applied Veterinary Sciences
Nowadays, there is a need for good and efficacious NSAIDs with minimal side effects to be applied in veterinary medicine. The aim was to compare the pharmacodynamics (analgesia and inhibition of COX-2) and pharmacokinetics between selective (nimesulide ...
Taimaa Yahya, Yaareb Mousa
doaj   +1 more source

Cyclooxygenase-2 (COX-2)–Independent Anticarcinogenic Effects of Selective COX-2 Inhibitors [PDF]

JNCI: Journal of the National Cancer Institute, 2006
Nonsteroidal antiinflammatory drugs (NSAIDs) appear to reduce the risk of developing cancer. One mechanism through which NSAIDs act to reduce carcinogenesis is to inhibit the activity of cyclooxygenase-2 (COX-2), an enzyme that is overexpressed in various cancer tissues.
Grösch, Sabine, Maier, Thorsten, Schiffmann, Susanne, Geisslinger, Gerd   +3 more
openaire   +3 more sources

Common promoter variant in cyclooxygenase-2 represses gene expression: evidence of role in acute-phase inflammatory response [PDF]

, 2002
Objective: Cyclooxygenase (COX)-2 is a key regulatory enzyme in the synthesis of prostanoids associated with trauma and inflammation. We investigated the COX-2 gene for functional variants that may influence susceptibility to disease.
Brull, D.J., Hill, M.R., Humphries, S.E., Laurent, G.J., Marshall, R.P., McAnulty, R.J., Papafili, A.   +6 more
core   +1 more source

Staphylococcus aureus induces COX-2-dependent proliferation and malignant transformation in oral keratinocytes

Journal of Oral Microbiology, 2019
The COX-2/PGE2 axis can play roles in mediating the progression of tumor. COX-2 induction was observed in oral cancer. In our previous study, we found Staphylococcus aureus, a pathogen prevalent in oral cancer, can activate the COX-2/PGE2 pathway in ...
Yuxia Wang, Shiyu Liu, Bolei Li, Yaling Jiang, Xinxuan Zhou, Jing Chen, Mingyun Li, Biao Ren, Xian Peng, Xuedong Zhou, Lei Cheng   +10 more
doaj   +1 more source

Synthesis of 2-Methyl-3-indolylacetic Derivatives as Anti-Inflammatory Agents That Inhibit Preferentially Cyclooxygenase 1 without Gastric Damage [PDF]

, 2006
Novel substituted 2-methyl-3-indolylacetic derivatives were synthesized and evaluated for their activity in vitro and in vivo on COX-1 and COX-2. Active compounds were screened to determine their gastrointestinal tolerability in vivo in the rat.
C. Renner, CALIENDO, GIUSEPPE, CIRINO, GIUSEPPE, FIORINO, FERDINANDO, PERISSUTTI, ELISA, ROSSI, ANTONIETTA, ROVIEZZO, FIORENTINA, SANTAGADA, VINCENZO, SAUTEBIN, LIDIA, SEVERINO, BEATRICE   +9 more
core   +1 more source

Effects of oxidative stress-related major molecular parameters on milk composition in weaning period of damascus goats [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2022
Th e weaning process in goat breeding is applied in various methods depending on the breeding administration. In this study, blood and milk samples have been collected from Damascus goats at the weaning day (postpartum 105th day-weaned day) and a week ...
Hüseyin ÖZKAN, Sevda DALKIRAN, İrem KARAASLAN, Ufuk KAYA, Baran ÇAMDEVİREN, Murat YÜKSEL, Akın YAKAN   +6 more
doaj   +1 more source

Consequences of altered eicosanoid patterns for nociceptive processing in mPGES-1-deficient mice [PDF]

, 2007
Cyclooxygenase-2 (COX-2)-dependent prostaglandin (PG) E2 synthesis in the spinal cord plays a major role in the development of inflammatory hyperalgesia and allodynia. Microsomal PGE2 synthase-1 (mPGES-1) isomerizes COX-2-derived PGH2 to PGE2.
Angioni, Carlo Federico, Becker, Wiebke, Brenneis, Christian, Coste, Ovidiu, Geisslinger, Gerd, Nusing, Rolf M., Popp, Laura, Schmidt, Ronald, Scholich, Klaus   +8 more
core   +1 more source

High Expression of COX-2 Associated with the Depth of Invasion on Acral Melanoma by Increasing TGF-β1

Clinical, Cosmetic and Investigational Dermatology, 2021
Nastassa Gipsyianti, Afiati Aziz, Bethy S Hernowo, Hermin A Usman Department of Pathology Anatomy, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Hermin A UsmanDepartment of Pathology ...
Gipsyianti N, Aziz A, Hernowo BS, Usman HA   +3 more
doaj  

THE INHIBITORY EFFECT OF PROPOLIS AND CAFFEIC ACID PHENETHYLESTER ON CYCLOOXYGENASE ACTIVITY IN J774 MACROPHAGES. [PDF]

, 2002
The effect of an ethanolic extract of propolis, with and without CAPE, and some of its components on cyclooxygenase (COX-1 and COX-2) activity in J774 macrophages has been investigated.
BORRELLI, FRANCESCA, LIGRESTI A., LONGO R., ROSSI, ANTONIETTA, RUSSO A., SAUTEBIN, LIDIA   +5 more
core   +1 more source