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Expression of Concern: Blockade of interleukin-17A protects against coxsackievirus B3-induced myocarditis by increasing COX-2/PGE2 production in the heart. [PDF]

Pathog Dis
europepmc   +1 more source

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Genetics of coxsackievirus B3 cardiovirulence.

European Heart Journal, 1995
The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent ...
Nora M Chapman, Steven Tracy, Gunter Hufnagel   +2 more
exaly   +3 more sources

The structure of coxsackievirus B3 at 3.5 å resolution [PDF]

Structure, 1995
Group B coxsackieviruses (CVBs) are etiologic agents of a number of human diseases that range in severity from asymptomatic to lethal infections. They are small, single-stranded RNA icosahedral viruses that belong to the enterovirus genus of the picornavirus family. Structural studies were initiated in light of the information available on the cellular
Frank J Dutko, Daniel C Pevear, I Minor
exaly   +3 more sources

COXSACKIEVIRUS B3 IN HUMAN MILK

The Pediatric Infectious Disease Journal, 2006
Coxsackievirus B3 can cause severe neonatal disease with high mortality. We present the first report of detection of coxsackievirus B3 in the mothers' milk of 2 severely infected neonates by culture and reverse transcriptase-polymerase chain reaction. Reverse transcriptase-polymerase chain reaction is a rapid and sensitive tool to detect coxsackievirus
Mei-Ling, Chang, Kuo-Chien, Tsao, Chi-Chia, Huang, Meng-Hsiu, Yen, Chung-Guei, Huang, Tzou-Yien, Lin   +5 more
openaire   +2 more sources

The Structure of Coxsackievirus B3

1997
Picornaviruses are small, nonenveloped, icosahedral viruses. The mature virions are approximately 300 A in diameter and the interior of the capsid shell is packed with single-stranded plus sense RNA (Mw ∼ 8×106 Daltons) (Rueckert 1990). The virus capsid is composed of 60 protomers, each consisting of one copy of the viral proteins VP1, VP2, VP3 and VP4
J K, Muckelbauer, M G, Rossmann
openaire   +2 more sources

Molecular epidemiology of a coxsackievirus B3 outbreak

Journal of Medical Virology, 1991
AbstractAn outbreak of coxsackievirus B3 infection occurred in South Africa in 1984 with a variety of clinical manifestations being observed. Fifty‐one isolates from patients ranging in age from young babies to middle‐aged adults were obtained. To define further the epidemiology of this outbreak all isolates were characterised by either 1‐ or 2 ...
E, Rossouw, C W, Tsilimigras, B D, Schoub   +2 more
openaire   +2 more sources

Genetic Determinants of Coxsackievirus B3 Pathogenesis

Annals of the New York Academy of Sciences, 2002
Abstract:The development of high throughput genomic and bioinformatic analysis tools, coupled with established molecular techniques, has allowed new insights into the pathogenesis of infectious diseases. In humans, coxasackievirus B3 (CVB3) is the primary etiological agent of viral myocarditis, an inflammatory disease process involving the heart muscle.
Bruce M, McManus, Bobby, Yanagawa, Nana, Rezai, Honglin, Luo, Lydia, Taylor, Mary, Zhang, Jane, Yuan, Jonathan, Buckley, Timothy, Triche, George, Schreiner, Decheng, Yang   +10 more
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Perinatal Transmission of Coxsackievirus B3 in Mice

Journal of Infectious Diseases, 1987
Oral infection of pregnant mice with coxsackievirus B3 (CB3) late in gestation produced maternal viremia, which peaked three to four days after challenge, then rapidly diminished. Ninety percent of mice developed IgG antibody to CB3 by ten days after challenge.
J F, Modlin, M, Bowman
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Generation of a microRNA-Regulated Oncolytic Coxsackievirus B3

2022
The members of the picornavirus family include various viruses which, due to their impressive oncolytic activity, have the potential to be used for the treatment of cancer. However, the replication of these oncolytic viruses (OV) is not limited to tumor cells but can also take place in various normal tissues.
Babette, Dieringer, Leslie, Elsner, Ahmet, Hazini, Jens, Kurreck, Henry, Fechner   +4 more
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Genomic regions of coxsackievirus B3 associated with cardiovirulence

Journal of Medical Virology, 1997
The molecular basis for cardiovirulence in the coxsackievirus B3 (CVB3) genome was examined in a murine model of acute myocarditis. Infectious cDNAs representing a highly cardiovirulent coxsackievirus B3 (CVB3m) and a noncardiovirulent (CVB30) virus were used to construct infectious chimeric cDNAs.
C, Lee, E, Maull, N, Chapman, S, Tracy, C, Gauntt   +4 more
openaire   +2 more sources