Results 181 to 190 of about 12,093 (219)

Genetics of coxsackievirus B3 cardiovirulence

European Heart Journal, 1995
The human enteroviruses, especially the coxsackie B viruses, have been established as aetiologic agents of human inflammatory heart disease, a condition which may lead to dilated cardiomyopathy and heart failure. It is clear from murine models of coxsackievirus B3-induced inflammatory heart disease that not all strains of the virus are cardiovirulent ...
S, Tracy, Z, Tu, N, Chapman, G, Hufnagel
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Replicase gene of coxsackievirus B3

Journal of Virology, 1984
A cDNA copy covering two-thirds of the coxsackievirus B3 genome was cloned in the PstI site of the pBR322 vector. A nucleotide sequence containing the gene for the viral replicase and the 3' noncoding region of the coxsackievirus B3 genome was determined.
P O, Stålhandske, M, Lindberg, U, Pettersson   +2 more
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Coxsackievirus B3 modulates cardiac ion channels

The FASEB Journal, 2013
Infections with coxsackieviruses of type B (CVBs), which are known to induce severe forms of acute and chronic myocarditis, are often accompanied by ventricular arrhythmias and sudden cardiac death. The mechanisms underlying the development of virus‐induced, life‐threatening arrhythmias, which are pheno‐typically similar to those ...
Katja, Steinke, Frank, Sachse, Nicole, Ettischer, Nathalie, Strutz-Seebohm, Ulrike, Henrion, Matthias, Rohrbeck, Rafael, Klosowski, Dirk, Wolters, Stefan, Brunner, Wolfgang-Michael, Franz, Lutz, Pott, Carlos, Munoz, Reinhard, Kandolf, Eric, Schulze-Bahr, Florian, Lang, Karin, Klingel, Guiscard, Seebohm   +16 more
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Genetic Determinants of Coxsackievirus B3 Pathogenesis

Annals of the New York Academy of Sciences, 2002
Abstract:The development of high throughput genomic and bioinformatic analysis tools, coupled with established molecular techniques, has allowed new insights into the pathogenesis of infectious diseases. In humans, coxasackievirus B3 (CVB3) is the primary etiological agent of viral myocarditis, an inflammatory disease process involving the heart muscle.
Bruce M, McManus, Bobby, Yanagawa, Nana, Rezai, Honglin, Luo, Lydia, Taylor, Mary, Zhang, Jane, Yuan, Jonathan, Buckley, Timothy, Triche, George, Schreiner, Decheng, Yang   +10 more
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The Structure of Coxsackievirus B3

1997
Picornaviruses are small, nonenveloped, icosahedral viruses. The mature virions are approximately 300 A in diameter and the interior of the capsid shell is packed with single-stranded plus sense RNA (Mw ∼ 8×106 Daltons) (Rueckert 1990). The virus capsid is composed of 60 protomers, each consisting of one copy of the viral proteins VP1, VP2, VP3 and VP4
J K, Muckelbauer, M G, Rossmann
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Extracellular Matrix Remodeling in Coxsackievirus B3 Myocarditis

Clinical Immunology and Immunopathology, 1997
The connective tissue abnormality in relation to T lymphocytes was investigated in murine myocarditis. Inbred BALB/c-nu/+ (euthymic and normal T cell function) and BALB/c-nu/nu (athymic and T cell deficient) mice were inoculated with coxsackievirus B3 (CB3). Hearts were stained with hematoxylin-eosin, Malloryazan, and silver impregnation, for reticulin
C, Kishimoto, M, Kitazawa, Y, Hiraoka, H, Takada   +3 more
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Colchicine aggravates coxsackievirus B3 infection in mice

International Journal of Cardiology, 2016
There is a clinical need for immunosuppressive therapy that can treat myocarditis patients in the presence of an active viral infection. In this study we therefore investigated the effects of colchicine, an immunosuppressive drug which has been used successfully as treatment for pericarditis patients, in a mouse model of coxsackievirus B3(CVB3)-induced
Smilde, Bernard J., Woudstra, Linde, Fong Hing, Gene, Wouters, Diana, Zeerleder, Sacha, Murk, Jean-Luc, van Ham, Marieke, Heymans, Stephane, Juffermans, Lynda J. M., van Rossum, Albert C., Niessen, Hans W. M., Krijnen, Paul A. J., Emmens, Reindert W.   +12 more
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Coxsackievirus B3 clinical isolates and murine myocarditis

Virus Research, 1996
Fifteen clinical coxsackievirus B3 (CVB3) isolates were assessed for cardiopathologic capabilities in adolescent male CD-1 mice in comparison to two well characterized cardiovirulent CVB3 strains. One isolate was cardiovirulent, one minimally cardiovirulent and the remaining 13 isolates were noncardiovirulent.
C J, Gauntt, M A, Pallansch
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Molecular epidemiology of a coxsackievirus B3 outbreak

Journal of Medical Virology, 1991
AbstractAn outbreak of coxsackievirus B3 infection occurred in South Africa in 1984 with a variety of clinical manifestations being observed. Fifty‐one isolates from patients ranging in age from young babies to middle‐aged adults were obtained. To define further the epidemiology of this outbreak all isolates were characterised by either 1‐ or 2 ...
E, Rossouw, C W, Tsilimigras, B D, Schoub   +2 more
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Cardiomyocyte apoptosis in experimental coxsackievirus B3 myocarditis

Cardiovascular Pathology, 2003
Viruses are known to induce apoptosis in their host cells. We studied whether cardiomyocyte apoptosis occurs upon coxsackievirus B3 (CVB3) infection and whether virus-associated apoptosis plays a role in the pathogenesis of experimental myocarditis.BALB/c mice were infected with two variants of CVB3 causing either mild or severe myocarditis. Myocardial
Antti, Saraste, Anita, Arola, Tytti, Vuorinen, Ville, Kytö, Markku, Kallajoki, Kari, Pulkki, Liisa-Maria, Voipio-Pulkki, Timo, Hyypiä   +7 more
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