Results 81 to 90 of about 12,093 (219)

Suppression of Calcium Influx Reduces Coxsackievirus B3 Lethality With Elevated Interferon Beta Responses in Mice

Journal of Medical Virology, Volume 98, Issue 5, May 2026.
ABSTRACT The disease course of severe enterovirus (EV) infection with hepatic necrosis is usually fulminant and fatal. Coxsackievirus (CVB3) is the emerging and important serotype of newborn EV inducing hepatic necrosis. Calcium (Ca2+) regulates host immunity, type I interferon (IFN‐I), and viral infections.
Yi‐Ling Hsiao, Cheng‐Huei Hung, Ming Te Yeh, Shun‐Hua Chen   +3 more
wiley   +1 more source

Major Persistent 5′ Terminally Deleted Coxsackievirus B3 Populations in Human Endomyocardial Tissues

Emerging Infectious Diseases, 2016
We performed deep sequencing analysis of the enterovirus 5′ noncoding region in cardiac biopsies from a patient with dilated cardiomyopathy. Results displayed a mix of deleted and full-length coxsackievirus B3, characterized by a low viral RNA load (8 ...
Alexis Bouin, Yohan Nguyen, Michel Wehbe, Fanny Renois, Paul Fornes, Firouze Bani-Sadr, Damien Metz, Laurent Andreoletti   +7 more
doaj   +1 more source

Coxsackievirus B3 mutator strains are attenuated in vivo [PDF]

Proceedings of the National Academy of Sciences, 2012
Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed us to probe the effects of lowering fidelity on virus replication, mutability, and in vivo fitness.
Nina F. Gnädiga, b, Stéphanie Beaucourta, Grace Campagnolac, Antonio V. Borderíaa, Marta Sanz-Ramosa, Peng Gongc, Hervé Blanca, Olve B. Peersenc, and Marco Vignuzzi   +9 more
openaire   +3 more sources

Coronavirus Nsp3 Hijacks CLTC to Modulate Autophagosome Nucleation for Promoting DMV Formation and Viral Replication

Advanced Science, Volume 13, Issue 24, 27 April 2026.
In wild‐type cells, FIPV infection recruits CLTC to nsp3, facilitates DMV biogenesis and block autophagic flux to promote viral replication. CLTC knockout impairs autophagosome nucleation by reducing Beclin1–ATG14 complex expression. This disrupts the formation of autophagic precursor membranes, thereby preventing their hijacking by nsp3 for DMV ...
Juan Xu, Hang Li, Peng Liu, Zhe Jiao, Ding Zhang, Zhelin Su, Sai Niu, Jintao Zhang, Yuejun Shi, Guiqing Peng   +9 more
wiley   +1 more source

Cell type-specific roles of PAR1 in Coxsackievirus B3 infection

Scientific Reports, 2021
Protease-activated receptor 1 (PAR1) is widely expressed in humans and mice, and is activated by a variety of proteases, including thrombin. Recently, we showed that PAR1 contributes to the innate immune response to viral infection.
Michael F. Bode, Clare M. Schmedes, Grant J. Egnatz, Vanthana Bharathi, Yohei M. Hisada, David Martinez, Tomohiro Kawano, Alice Weithauser, Leah Rosenfeldt, Ursula Rauch, Joseph S. Palumbo, Silvio Antoniak, Nigel Mackman   +12 more
doaj   +1 more source

Autoimmunity in coxsackievirus B3 induced myocarditis

Autoimmunity, 2006
Virus infections are implicated in several autoimmune diseases. Multiple mechanisms of autoimmunity induction have been proposed including antigenic mimicry, production of cryptic epitopes and infection acting as both adjuvant for self-antigens and the mechanism of releasing these cell antigens.
openaire   +2 more sources

Coxsackievirus B3 infection reduces female mouse fertility

Experimental Animals, 2015
Previously we demonstrated coxsackievirus B3 (CVB3) infection during early gestation as a cause of pregnancy loss. Here, we investigated the impacts of CVB3 infection on female mouse fertility. Coxsackievirus-adenovirus receptor (CAR) expression and CVB3 replication in the ovary were evaluated by immunohistochemistry or reverse transcription-polymerase
Shim, Hye Min, Hwang, Ji Young, Lee, Kyung Min, Kim, Yunhwa, Jeong, Daewon, Roh, Jaesook, Choi, Hyeonhae, Hwang, Jung Hye, Park, Hosun   +8 more
openaire   +3 more sources

Autophagosome Supports Coxsackievirus B3 Replication in Host Cells [PDF]

Journal of Virology, 2008
ABSTRACT Recent studies suggest a possible takeover of host antimicrobial autophagy machinery by positive-stranded RNA viruses to facilitate their own replication. In the present study, we investigated the role of autophagy in coxsackievirus replication.
Jerry, Wong, Jingchun, Zhang, Xiaoning, Si, Guang, Gao, Ivy, Mao, Bruce M, McManus, Honglin, Luo   +6 more
openaire   +2 more sources

How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection

Immunological Reviews, Volume 338, Issue 1, March 2026.
ABSTRACT Urinary tract infections possess substantial sex disparities in the incidence, immune response, and progression of infection. Some of these distinctions may be due to sexual dimorphism in mucosal barriers or sex differences in the initial immune response to infection.
Laura Ramirez Finn, Molly A. Ingersoll
wiley   +1 more source

Cross-reactions of immunoglobulin M and G antibodies with enterovirus-specific viral structural proteins [PDF]

, 2017
We analysed the reactivity of enterovirus-specific human IgM and IgG antibodies with the structural proteins of different enteroviruses by the immunoblot technique.
Burkhardt, F., Reigel, F., Schilt, U.
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