Results 61 to 70 of about 69,182 (204)

Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia

MedComm, Volume 7, Issue 11, November 2026.
Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Tian‐Zhang Song, Li‐Rong Zhang, Yun‐Mei Wang, Yan Hu, Qing Li, Ren‐Rong Tian, Liu‐Meng Yang, Si‐Dong Xiong, Dong‐Dong Wu, Yong‐Tang Zheng   +9 more
wiley   +1 more source

Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis

Journal of Immunology Research, 2017
Background. Infection with Coxsackievirus B3 induces myocarditis. We aimed to compare the acute and chronic phases of viral myocarditis to identify the immediate effects of cardiac inflammation as well as the long-term effects after resolved inflammation
Peter Moritz Becher, Frauke Gotzhein, Karin Klingel, Felicitas Escher, Stefan Blankenberg, Dirk Westermann, Diana Lindner   +6 more
doaj   +1 more source

Oncolytic activity of a coxsackievirus B3 strain in human endometrial cancer cell lines

Virology Journal, 2018
Background Endometrial cancer (EC) is one of the most common gynecological malignancies globally. Although progress has been made in surgical and other adjuvant therapies, there is still a great need to develop new approaches to further reduce the ...
Yanzhen Lin, Wei Wang, Junkai Wan, Ying Yang, Wenkun Fu, Dequan Pan, Linli Cai, Tong Cheng, Xiumin Huang, Yifeng Wang   +9 more
doaj   +1 more source

Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3

Molecular Therapy: Oncolytics, 2022
Genetic modification of coxsackievirus B3 (CVB3) by inserting target sequences (TS) of tumor-suppressive and/or organ-selective microRNAs (miRs) into viral genome can efficiently eliminate viral pathogenesis without significant impacts on its oncolytic ...
Huitao Liu, Amirhossein Bahreyni, Yasir Mohamud, Yuan Chao Xue, William W.G. Jia, Honglin Luo   +5 more
doaj   +1 more source

Coxsackievirus B3 mutator strains are attenuated in vivo [PDF]

Proceedings of the National Academy of Sciences, 2012
Based on structural data of the RNA-dependent RNA polymerase, rational targeting of key residues, and screens for Coxsackievirus B3 fidelity variants, we isolated nine polymerase variants with mutator phenotypes, which allowed us to probe the effects of lowering fidelity on virus replication, mutability, and in vivo fitness.
Nina F. Gnädiga, b, Stéphanie Beaucourta, Grace Campagnolac, Antonio V. Borderíaa, Marta Sanz-Ramosa, Peng Gongc, Hervé Blanca, Olve B. Peersenc, and Marco Vignuzzi   +9 more
openaire   +3 more sources

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, Volume 13, Issue 57, 14 October 2026.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Cross‐Neutralizing and Broadly Neutralizing Human Antibodies Against Nonenveloped Viruses

European Journal of Immunology, Volume 56, Issue 10, October 2026.
In this review article, Marchand et al. compare cross ‐ and broadly ‐neutralizing human antibodies against non ‐ enveloped viruses from several major families, discussing their structural characteristics, neutralization mechanisms and relevance for the development of antiviral vaccines and therapeutics.
Sarah Marchand, Samy Taouli, Dorian McIlroy   +2 more
wiley   +1 more source

Neonatal sepsis due to Coxsackievirus B3 complicated by liver failure and pulmonary hemorrhage

Case Reports in Perinatal Medicine, 2022
Coxsackievirus B3 (CVB3) is a single-stranded RNA included in the “Human Enterovirus B” category associated with multiple, even severe, health issues in humans. Newborns are at risk of life-threatening conditions due to enteroviral infections.
Thach Rasmey, Gitto Lorenzo
doaj   +1 more source

Evasins: Biology and Therapeutic Potential of Broad‐Spectrum Chemokine Inhibitors

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
ABSTRACT Ticks are haematophagous parasites that rely on uninterrupted bloodmeals for survival and need an effective strategy to suppress the host inflammatory response. Leukocyte recruitment is a chemokine‐mediated hallmark of inflammation, which ticks counteract via anti‐chemokine proteins in their saliva named evasins.
Emilia L. Bialek, Roos Buds, Ingrid Dijkgraaf, Pedro E. Marques   +3 more
wiley   +1 more source

Search for Coxsackievirus B3 RNA in idiopathic dilated cardiomyopathy using gene amplification by polymerase chain reaction

, 1992
A polymerase chain reaction (PCR) amplification assay was developed to detect Coxsackievirus B3 ribonucleic acid (RNA) in blood and myocardial tissue of explanted hearts from 40 patients who underwent cardiac transplantation and in 1 normal heart. Twenty-
Arbustini E., Vigano M., Bramerio M., Gavazzi A., Diegoli M., Percivalle E., Grasso M., Silini E., Ratti G., Milanesi G.   +9 more
core   +1 more source