Results 51 to 60 of about 69,182 (204)

Targeting the Myocardial Microenvironment: Novel Antiviral Strategies and Therapeutic Perspectives for Coxsackievirus B–Induced Myocarditis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Coxsackievirus B3 is a primary cause of viral myocarditis, with ≈20% of cases progressing to dilated cardiomyopathy. Despite its clinical significance, therapeutic strategies remain limited.
Yang Yue, Chengda Wei, Mengmeng Ding, Xiuwei Zhang, Xuemei Li, Lu Liu, Chengcheng Liu, Ce Wang   +7 more
doaj   +1 more source

Treatment of Neonatal Infection Caused by Coxsackievirus B3 [PDF]

Journal of Perinatology, 1999
Four male infants with early neonatal infection caused by coxsackievirus B3 (presumed in one case) exhibited severe thrombocytopenia and liver dysfunction at presentation. The three infants who were administered human normal immunoglobulin within 3 days of disease onset survived, while the fourth infant, who received the preparation 6 days after ...
H, Kimura, H, Minakami, A, Harigaya, H, Takeuchi, A, Tachibana, K, Otsuki   +5 more
openaire   +2 more sources

Cardiomyopathy Caused by Coxsackievirus Strain A9 in Previously Healthy Child, Northeastern France, 2024

Emerging Infectious Diseases
We characterized a recombinant mosaic coxsackievirus A9 strain responsible for severe inflammatory cardiomyopathy in a previously healthy child in northeastern France in 2024 by using whole-genome sequencing.
Anne-Laure Lebreil, Maxime Bisseux, Audrey Mirand, Marie Glenet, Yohan N’Guyen, Norhan Taha, Pierre Mauran, Cecile Henquell, Laurent Andreoletti   +8 more
doaj   +1 more source

Benserazide, the first allosteric inhibitor of Coxsackievirus B3 3C protease [PDF]

, 2015
Coxsackievirus B3 is the main cause of human viral myocarditis and cardiomyopathy. Virally encoded Coxsackievirus 3C protease (3Cpro) plays an essential role in viral proliferation.
Cho, Joong-Heui, Jeong, Pyeonghwa, Lee, Youngjin, Park, Kyoung Ryoung, Eom, Soo Hyun, Lim, Jia Jia, Kim, Yong-Chul, Kim, Bo-Kyoung   +7 more
core   +1 more source

Reversible Atrioventricular Block and Junctional Ectopic Tachycardia in Coxsackievirus B3-Induced Fetal–Neonatal Myocarditis without Left Ventricular Dysfunction

American Journal of Perinatology Reports, 2011
We present a case of fetal–neonatal acute myocarditis caused by coxsackievirus B3 infection in a term neonate. The condition manifested as high-grade atrioventricular (A-V) block prenatally.
Hironori Takahashi, Keiko Tsukamoto, Shigehiro Takahashi, Tomoo Nakamura, Yushi Ito, Masahide Kaneko, Haruhiko Sago   +6 more
doaj   +1 more source

ATP Is an Allosteric Inhibitor of Coxsackievirus B3 Polymerase [PDF]

Biochemistry, 2016
The RNA-dependent RNA polymerases from positive-strand RNA viruses, such as picornaviruses and flaviviruses, close their active sites for catalysis via a unique NTP-induced conformational change in the palm domain. Combined with a fully prepositioned templating nucleotide, this mechanism is error-prone and results in a distribution of random mutations ...
Jonathan P, Karr, Olve B, Peersen
openaire   +2 more sources

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Sphingosine‐1‐Phosphate Attenuates LPS‐Induced Inflammatory Cardiac Injury in Association With RASGRP1–S100A9–NLRP3 Signaling

Drug Development Research, Volume 87, Issue 7, November 2026.
ABSTRACT Lipopolysaccharide (LPS) induces endotoxemia‐associated inflammatory cardiac injury rather than classical viral or autoimmune myocarditis. Sphingosine‐1‐phosphate (S1P) regulates cardiovascular and immune responses, predominantly through S1P receptors, but whether it also modulates macrophage‐associated inflammatory signaling during LPS ...
Chaofu Yue, Qiaolin Li, Chunyan Li, Taoxian Yang, Xian Huang, Feng Yue, Qiuyu Long, Rong Li, Rong Lei, Qingsong Ma, Caimei Hu, Qian Yang, Yongjun Yan, Yuan Liu, QinYong Yan, Mei Yang   +15 more
wiley   +1 more source

Effect of metoprolol in acute coxsackievirus B3 murine myocarditis [PDF]

, 1988
Recent studies suggest that beta-adrenergic blocking agents show promise in the management of cardiomyopathies; however, their role in acute myocarditis is unknown.
Khatib, Riad, Rezkalla, Shereif, Kloner, Robert A., Smith, Frederick E., Khatib, Ghada   +4 more
core   +1 more source

The protective effects of ivabradine in preventing progression from viral myocarditis to dilated cardiomyopathy

Frontiers in Pharmacology, 2016
To study the beneficial effects of ivabradine in dilated cardiomyopathy mice, which evolved from coxsackievirus B3-induced chronic viral myocarditis. Four-to-five-week-old male balb/c mice were inoculated intraperitoneally with coxsackievirus B3 (Strain ...
Li Yue-Chun, Li Yue-Chun, Chen Guang-Yi, Ge Li-Sha, Xing Chao, Tian Xinqiao, Lin Cong, Dai Xiao-Ya, Xiangjun Yang   +8 more
doaj   +1 more source