Results 91 to 100 of about 164,159 (291)

Stimuli‐Responsive Supramolecular Biomaterials for Cancer Theranostics

Advanced Science, EarlyView.
The ultimate goal of cancer theranostics is to get imaging agents and therapeutic cargo to tumor sites when and where they are required. “Smart” systems should be developed. This review discusses the characteristics of physiological stimuli, types and action modes of external stimuli, construction approaches and working principles, as well as ...
Wenting Hu, Binglin Ye, Guocan Yu, Feihe Huang, Zhengwei Mao   +4 more
wiley   +1 more source

Impact of uncertainty in Utsira formation temperature and salinity on CO2 storage: A field-scale reactive transport simulation study

Carbon Capture Science & Technology
Saline aquifers offer large storage capacities for carbon dioxide (CO2) geo-sequestration. However, key parameters such as aquifer temperature and brine salinity often remain uncertain, especially in thick formations.
Mohamed Gamal Rezk, Ahmed Farid Ibrahim
doaj   +1 more source

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Beyond Biot – Nonlinear stiffening of the bulk modulus in fluid-saturated porous media

Results in Engineering
This paper comprehensively investigates the elastic behavior of fluid-saturated porous media, considering a far-field stress, a range of pore pressures, and varying pore sizes.
Axel Dorian Toko, Ruud Weijermars
doaj   +1 more source

Prognostic value of CpG island methylator phenotype among colorectal cancer patients: a systematic review and meta-analysis [PDF]

, 2014
Yen‐Yi Juo, Fabian M. Johnston, Dongyu Zhang, Hsin-Hsuan Juo, Haopeng Wang, Emmanouil P. Pappou, Tosol Yu, Hariharan Easwaran, Stephen B. Baylin, Manon van Engeland, Nita Ahuja   +10 more
openalex   +1 more source

Genome‐Wide Codon Reprogramming Enables a Multifactorially Attenuated Influenza Vaccine with Broad Cross‐Protection

Advanced Science, EarlyView.
Genome‐wide codon reprogramming of influenza A virus introduces 1956 synonymous mutations across five segments and elevates CpG content, causing defective NA packaging, loss of NS1 accumulation, and enhanced ZAP‐mediated antiviral responses without affecting RNA or protein synthesis. These mechanisms result in profound attenuation and potent homologous
Yang Wang, Tianxin Ma, Yujiao He, Qinming Li, Kailin Mai, Minying Mo, Chenyang Cao, Jiahui Li, Pei Feng, Jiaojiao Peng, Jing Sun, Weiqi Pan, Zifeng Yang, Ling Chen   +13 more
wiley   +1 more source

Pressure Transient Solutions for Unbounded and Bounded Reservoirs Produced and/or Injected via Vertical Well Systems with Constant Bottomhole Pressure

Fluids
Various analytical solutions for computing production and injection-induced pressure changes in aquifers and oil reservoirs have been derived over the past century. All prior solutions assumed a constant well rate as the boundary condition.
Ruud Weijermars, Clement Afagwu
doaj   +1 more source

Tobacco Smoke Exposure From Prenatal To Adolescent Periods Drives IBD Pathogenesis: Dynamic DNA Methylation Signatures Across Lifespan Stages

Advanced Science, EarlyView.
This study illustrates that maternal smoking during pregnancy (MSDP) is an independent risk factor for IBD in offspring, and DNA methylation serves as a key mechanistic pathway connecting early‐life smoking exposure with IBD risk in offspring. That highlights the urgent need for preventive interventions targeting prospective parents and minors to ...
Han Zhang, Jianhui Zhao, Jie Chen, Xinyi Ma, Siyun Zhou, Alexandra Noble, Rahul Kalla, Judith Wellens, Kun Liu, Evropi Theodoratou, Jack Satsangi, Xue Li   +11 more
wiley   +1 more source

Concurrent challenges in practical operations and modeling of geological carbon-dioxide sequestration: Review of the Gorgon project and FluidFlower benchmark study

Energy Strategy Reviews
This study aims to serve as a reality check on whether the present-day (1) technology readiness level, and (2) storage capacity modeling, are adequate to claim that geological carbon-dioxide sequestration (GCS) projects are on a trajectory to help save ...
Ruud Weijermars
doaj   +1 more source

A statistical method for excluding non-variable CpG sites in high-throughput DNA methylation profiling [PDF]

, 2010
Hailong Meng, Andrew R. Joyce, Daniel E. Adkins, P. Basu, Yankai Jia, Guoya Li, Tapas K. Sengupta, Barbara Zedler, E. Lenn Murrelle, Edwin J C G van den Oord   +9 more
openalex   +1 more source