Results 101 to 110 of about 487,995 (250)
BMC Bioinformatics, 2006 Background Despite their involvement in the regulation of gene expression and their importance as genomic markers for promoter prediction, no objective standard exists for defining CpG islands (CGIs), since all current approaches rely on a large ...
Carpena Pedro +5 more
doaj +1 more source
Multi‐omics–driven precision medicine
iMeta, EarlyView.Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li +20 more
wiley +1 more source
Teeing Up Transcription on CpG Islands [PDF]
Journal of End-to-End-testing, 2009 Eukaryotic cells use elaborate molecular mechanisms to rapidly activate signal-dependent gene expression. New work provides fresh insights into these mechanisms by demonstrating that CpG islands in promoters are nucleosome-destabilizing elements and can facilitate the establishment of an unusual poised transcriptional state (Ramirez-Carrozzi et al ...
openaire +2 more sources
Epigenetic Regulation of Liver Fibrosis: Mechanisms and Therapeutic Implications
Portal Hypertension &Cirrhosis, EarlyView.This review synthesizes the epigenetic mechanisms—DNA methylation, histone modifications, and non‐coding RNAs—that drive hepatic stellate cell activation and the progression of liver fibrosis. It further evaluates emerging therapeutic strategies targeting these epigenetic regulators, including DNA methyltransferase and histone deacetylase inhibitors ...
Maryam Jadid Tavaf +8 more
wiley +1 more source
Extensive sequence-influenced DNA methylation polymorphism in the human genome
Epigenetics & Chromatin, 2010 Background Epigenetic polymorphisms are a potential source of human diversity, but their frequency and relationship to genetic polymorphisms are unclear.
Hellman Asaf, Chess Andrew
doaj +1 more source
Andrology, EarlyView.ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick +7 more
wiley +1 more source
Analysis of CpG methylation sites and CGI among human papillomavirus DNA genomes
BMC Genomics, 2011 Background The Human Papillomavirus (HPV) genome is divided into early and late coding sequences, including 8 open reading frames (ORFs) and a regulatory region (LCR).
Galván Silvia C +7 more
doaj +1 more source
AOSNP‐ADAPTR resource level‐based recommendations on practical diagnostic strategies for ependymomas
Brain Pathology, EarlyView.Adapting Diagnostic Approaches for Practical Taxonomy in Resource‐Restrained Regions (ADAPTR) recommendations for ependymomas in resource‐restrained settings (RL = resource level; created in BioRender). Abstract Ependymomas are uncommon primary tumors of the central nervous system (CNS) that affect both children and adults.
Laveniya Satgunaseelan +13 more
wiley +1 more source
A Study Of Vertebrate CpG-islands-associated miRNA Genes
, 2009 [[abstract]]MicroRNAs(MIRNAs)are about 22 nucleotides small regulatory RNAs, which produced from hairpin-like precursors, and suppressing translation of target genes by binding to mRNA. MicroRNAs perform the role of gene regulation.
Jheng Shu Ping
core
CpG islands or CpG clusters: how to identify functional GC-rich regions in a genome?
BMC Bioinformatics, 2009 Background CpG islands (CGIs), clusters of CpG dinucleotides in GC-rich regions, are often located in the 5' end of genes and considered gene markers. Hackenberg et al.
Han Leng, Zhao Zhongming
doaj +1 more source