Results 101 to 110 of about 71,530 (247)

Diversity of core promoter elements comprising human bidirectional promoters

BMC Genomics, 2008
Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Elnitski Laura L, Yang Mary
doaj   +1 more source

In silico enhanced restriction enzyme based methylation analysis of the human glioblastoma genome using Agilent 244K CpG Island microarrays

Frontiers in Neuroscience, 2010
Genome wide methylation profiling of gliomas is likely to provide important clues to improving treatment outcomes. Restriction enzyme based approaches have been widely utilized for methylation profiling of cancer genomes and will continue to have ...
Anh Tran, Anh Tran, Cameron Escovedo, Cameron Escovedo, Justine Migdall-Wilson, Arthur Chou, Weidong Chen, Weidong Chen, Timothy Cloughesy, Timothy Cloughesy, Stanley Nelson, Albert Lai, Albert Lai   +12 more
doaj   +1 more source

Analysis of Human Uniparental Embryonic Stem Cells Reveals New Putative Imprinted Loci

Cell Proliferation, EarlyView.
To identify novel imprinted genes, parthenogenetic, androgenetic and biparental human embryonic stem cells and their differentiated neural progenitors were analysed by methylome and transcriptome profiling. This approach uncovered 12 putative novel imprinted genes, including a clustered region on chromosome 19, expanding the current catalogue of ...
Shay Kinreich, Nissim Benvenisty
wiley   +1 more source

CpG Islands: A Historical Perspective

, 2018
The discovery of CpG islands (CGIs) and the study of their structure and properties run parallel to the development of molecular biology in the last two decades of the twentieth century and to the development of high-throughput genomic technologies at the turn of the millennium.
Antequera, Francisco, Bird, Adrian
openaire   +3 more sources

A Framework to Investigate the Effects of Observation Error on Neural Network Predictions of Fish Age

Fish and Fisheries, EarlyView.
ABSTRACT Technological innovations for predicting fish age represent a paradigm shift from conventional age estimation methods used in fisheries science. Recently developed secondary methods rely on models trained on conventional age estimates, derived from subjective interpretation of growth patterns and a biological property of the fish to predict ...
Derek W. Chamberlin, Thomas E. Helser, John D. Brogan, Irina M. Benson, Jason Conner, Andrew T. Chin, Christopher M. Gburski, Mary Elizabeth Matta, Julie A. Pearce, Kali R. Stone, Todd T. TenBrink, Morgan B. Arrington   +11 more
wiley   +1 more source

Bidding the CpG island goodbye

eLife, 2013
Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
John M Greally
doaj   +1 more source

Enrichment analysis of Alu elements with different spatial chromatin proximity in the human genome [PDF]

, 2016
Transposable elements (TEs) have no longer been totally considered as “junk DNA” for quite a time since the continual discoveries of their multifunctional roles in eukaryote genomes.
A Antonaki, A Huda, A Nekrutenko, A Smallwood, AF Smit, AM Deaton, C Esnault, C Feschotte, CB Lowe, CT Ong, D Grover, D Grover, D Schmidt, D Xie, E Berezikov, E Lieberman-Aiden, E Wit de, E Yaffe, EP Nora, ES Lander, ES Lander, F Cui, G Bourque, G Kunarso, G Li, G Li, GA Maston, GJ Faulkner, GN Gallus, H Santos-Rosa, H Santos-Rosa, H Xie, HH Kazazian Jr, IK Jordan, J Banerji, J Dekker, J Dostie, J Jurka, J Jurka, J Ule, JA Yoder, JE Hambor, JF Brookfield, JF Brookfield, JM Chen, JR Dixon, JR Korenberg, K Ahn, K Kaer, KC Wang, L Lin, L Teng, M Hackenberg, M Simonis, M Weber, MA Batzer, MG Kidwell, MH Kagey, MJ Fullwood, MM Suzuki, ND Heintzman, NR Smalheiser, P Jin, P Medstrand, P Polak, R Cordaux, R Eskeland, R Lister, R Schneider, R Sorek, RD Hawkins, S Shen, S Winkler, SD Gillies, SL Oei, T Pastor, T Wicker, V Kapitonov, VJ Lynch, WD Gifford, Y Lu, Y Quentin, Y Quentin, Y Zhang   +83 more
core   +4 more sources

Distribution of DNA methylation, CpGs, and CpG islands in human isochores

Genomics, 2010
DNA methylation is a major epigenetic modification of the genome that affects basic biological functions, such as gene expression and cell development. We used the human genome sequences and the DNA methylation data that are available in order to establish a map of the levels of GC and methylation in isochores.
Varriale, Annalisa, Bernardi, Giorgio
openaire   +2 more sources

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source