Results 81 to 90 of about 47,629 (244)

Rising Incidence and Mortality of Colorectal Cancer Among Younger Adults: A Population‐Based Study in Taiwan, 1994–2018

International Journal of Cancer, EarlyView.
Colorectal cancer incidence and mortality have increased in the Asia‐Pacific region over the past three decades. This population‐based study in Taiwan suggests a shift of the colorectal cancer burden towards the younger generations. An age–period–cohort model revealed higher annual increases in incidence (3.58%) and mortality (1.0%) rates among ...
Yun‐Chen Tsai, Chih‐Yi Wu, Tsung‐I Hung, Hung‐Yi Chiou   +3 more
wiley   +1 more source

Diversity of core promoter elements comprising human bidirectional promoters

BMC Genomics, 2008
Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Elnitski Laura L, Yang Mary
doaj   +1 more source

In silico enhanced restriction enzyme based methylation analysis of the human glioblastoma genome using Agilent 244K CpG Island microarrays

Frontiers in Neuroscience, 2010
Genome wide methylation profiling of gliomas is likely to provide important clues to improving treatment outcomes. Restriction enzyme based approaches have been widely utilized for methylation profiling of cancer genomes and will continue to have ...
Anh Tran, Anh Tran, Cameron Escovedo, Cameron Escovedo, Justine Migdall-Wilson, Arthur Chou, Weidong Chen, Weidong Chen, Timothy Cloughesy, Timothy Cloughesy, Stanley Nelson, Albert Lai, Albert Lai   +12 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Maternal overweight and obesity during pregnancy and sex‐dependent dysregulation of the materno‐fetal stress axis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective Maternal obesity and excess gestational weight gain (GWG) are linked to adverse perinatal outcomes, potentially via disruption of the maternal–fetal stress axis. Placental HSD11B2 protects the fetus from excess glucocorticoids and may influence fetal programming during maternal metabolic stress.
Thorsten Braun, Marie Hofmann, Rebecca Rancourt, Julia Sommer, Alexandra Kühn, Loreen Ehrlich, Thomas Ziska, Kerstin Melchior, Karen Schellong, Wolfgang Henrich, Sonja Entringer, Katherine Margaret Kennedy, Andreas Plagemann, Deborah Magdalena Sloboda   +13 more
wiley   +1 more source

Understanding the role of CFP1 at CpG islands

, 2014
Vertebrate genomes are punctuated by CpG islands regions, which have an elevated frequency of CpG dinucleotides. CpG islands are associated with over 70% of mammalian promoters suggesting they may contribute to the regulation of transcription.
Schermelleh, Lothar, Klose, Rob, Brown, David   +2 more
core   +3 more sources

Bidding the CpG island goodbye

eLife, 2013
Experiments on seven vertebrates suggest that identifying the locations of islands of non-methylated DNA provides more insights into evolutionarily-conserved epigenetic regulatory elements than studies of CpG islands.
John M Greally
doaj   +1 more source

Distribution of DNA methylation, CpGs, and CpG islands in human isochores

Genomics, 2010
DNA methylation is a major epigenetic modification of the genome that affects basic biological functions, such as gene expression and cell development. We used the human genome sequences and the DNA methylation data that are available in order to establish a map of the levels of GC and methylation in isochores.
Varriale, Annalisa, Bernardi, Giorgio
openaire   +2 more sources

Identifying High‐Risk Children Safe for Same‐Day Discharge After Tonsillectomy

The Laryngoscope, EarlyView.
ABSTRACT Objective Current guidelines recommend overnight admission for children with severe obstructive sleep apnea (OSA) and obesity undergoing tonsillectomy, although most have uneventful postoperative courses. We aimed to identify low‐risk subgroups within this high‐risk population who may be candidates for same‐day discharge. Methods Retrospective
Amy Ho, Yann‐Fuu Kou, Christopher Liu, Cynthia S. Wang, Felicity Lenes‐Voit, Stephen R. Chorney, Kenneth Lee, Seckin Ulualp, Ron B. Mitchell, Romaine F. Johnson   +9 more
wiley   +1 more source

Leukocyte profiles reveal sex and age differences in immune investment in a polygynous bat

Journal of Animal Ecology, EarlyView.
Analysis of over 500 blood cell profiles, including repeat samples over four years, reveals that male bats from a long‐lived species with a polygynous mating system invest more in innate than adaptive immunity. Investment in innate immunity increases with age, as estimated by a DNA methylation clock and mark‐recapture data.
Gerald S. Wilkinson, Jillian A. Kaiser, Katherine N. Armenta, Ana S. G. Cunningham, Severine B. S. W. Hex, Alexis M. Lawson, Jack G. Rayner   +6 more
wiley   +1 more source