Results 81 to 90 of about 71,530 (247)
Journal of Surgical Oncology, EarlyView.ABSTRACT Colorectal cancer is the third most common cancer worldwide, and the proportion of individuals diagnosed under the age of 50 years, referred to as early‐onset colorectal cancer (EOCRC), is increasing. The aim of this study was to evaluate how the demographic and clinical features of EOCR in northern Sweden and Finland have changed over time ...
Melina Charalambidi +11 more
wiley +1 more source
Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism [PDF]
, 2018 In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes.
Billi, Monia +9 more
core +1 more source
Identifying High‐Risk Children Safe for Same‐Day Discharge After Tonsillectomy
The Laryngoscope, EarlyView.ABSTRACT Objective Current guidelines recommend overnight admission for children with severe obstructive sleep apnea (OSA) and obesity undergoing tonsillectomy, although most have uneventful postoperative courses. We aimed to identify low‐risk subgroups within this high‐risk population who may be candidates for same‐day discharge. Methods Retrospective
Amy Ho +9 more
wiley +1 more source
Med Research, EarlyView.ABSTRACT With multi‐omics approaches increasingly employed to investigate multidimensional biological systems, current workflows often lack sufficient integration with the underlying genome, limiting comprehensive understanding of genomic structure and chromosomal preferences of candidate genes. Here, we present GAnnoViz (https://github.com/benben‐miao/
Benben Miao +8 more
wiley +1 more source
Epigenetic status of argininosuccinate synthetase and argininosuccinate lyase modulates autophagy and cell death in glioblastoma. [PDF]
, 2012 Arginine deprivation, either by nutritional starvation or exposure to ADI-PEG20, induces adaptive transcriptional upregulation of ASS1 and ASL in glioblastoma multiforme ex vivo cultures and cell lines.
Awad, M +13 more
core +1 more source
Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome
The Prostate, EarlyView.ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat +8 more
wiley +1 more source
An Unusual 500,000 Bases Long Oscillation of Guanine and Cytosine Content in Human Chromosome 21
, 2004 An oscillation with a period of around 500 kb in guanine and cytosine content (GC%) is observed in the DNA sequence of human chromosome 21. This oscillation is localized in the rightmost one-eighth region of the chromosome, from 43.5 Mb to 46.5 Mb.
Aaltonen +44 more
core +2 more sources
Solution structure of human MBD1 CXXC1 [PDF]
, 2015 No abstract ...
Smith, Brian O., Thomson, Ross
core +2 more sources
Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping [PDF]
Journal of Clinical Laboratory Analysis, 2015 BackgroundDetermination of the differential DNA methylation patterns of methylenetetrahydrofolate reductase (MTHFR) that are associated with differential MTHFR activity is important to understand the pathogenesis of ischemic stroke. However, to date, no data are available on the differential DNA methylation profiles of Kelantanese Malays. Therefore, we
Loo, Keat Wei +6 more
openaire +3 more sources
Andrology, EarlyView.ABSTRACT Background The tight junction protein CLDN6 has been identified as a cancer‐associated cell surface marker that is rarely expressed in healthy tissues. In testicular germ cell tumors (GCT), CLDN6 is particularly detectable in seminomas, embryonal carcinomas, and choriocarcinomas.
Jule Zwick +7 more
wiley +1 more source