Results 61 to 70 of about 47,629 (244)

Methylenetetrahydrofolate Reductase CpG Islands: Epigenotyping [PDF]

Journal of Clinical Laboratory Analysis, 2015
BackgroundDetermination of the differential DNA methylation patterns of methylenetetrahydrofolate reductase (MTHFR) that are associated with differential MTHFR activity is important to understand the pathogenesis of ischemic stroke. However, to date, no data are available on the differential DNA methylation profiles of Kelantanese Malays. Therefore, we
Loo, Keat Wei, Sutherland, Heidi, Au, Anthony, Camilleri, Emily, Haupt, Larisa, Gan, Siew Hua, Griffiths, Lyn   +6 more
openaire   +3 more sources

Integrative Omics Analysis Reveals the Regulation of Hypoxia Tolerance in Large Yellow Croaker (Larimichthys crocea) via the Lipoic Acid Synthase (lias) Gene

Advanced Science, EarlyView.
Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding, Songpeng Jia, Ran Meng, Xuelei Wang, Xiongfei Wu, Weiliang Shen, Yibo Zhang, Junquan Zhu   +7 more
wiley   +1 more source

Defining the protein complement of CpG islands [PDF]

, 2011
In higher eukaryotes, the DNA base Cytosine can exist in a variety of modified forms when in the dinucleotide CpG. Although a methylated form tends to dominate within the genome, approximately 1% of all CpG dinucleotides are found unmodified at high ...
Thomson, John Paterson
core  

Determinate the CpG Islands by the online CpG Islands prediction software.

, 2017
Several CpG islands was shown as light blue color. (TIF)
Raheleh Farahzadi (3860311), Seyed Alireza Mesbah-Namin (4598359), Nosratollah Zarghami (4598362), Ezzatollah Fathi (3860308)   +3 more
core   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Primers for amplification of CpG islands.

, 2013
Primers for amplification of CpG islands.
Yan Zhong (316566), Jing-Ping Hu (316560), Qiang Qu (316561), Jiang Li (272926), Wei Ren (267391), Sai-Qun Luo (316559), Wei-Xin Hu (316567), Jia-Ming Zhang (316564)   +7 more
core   +1 more source

A Study Of Vertebrate CpG-islands-associated miRNA Genes

, 2009
[[abstract]]MicroRNAs(MIRNAs)are about 22 nucleotides small regulatory RNAs, which produced from hairpin-like precursors, and suppressing translation of target genes by binding to mRNA. MicroRNAs perform the role of gene regulation.
Jheng Shu Ping
core   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

A Pan‐Methylome Framework for Population‐Scale Bacterial Epigenomics

Advanced Science, EarlyView.
A scalable quantitative framework unlocks population‐level comparative epigenomics in bacteria. By transforming site‐level data into standardized traits, this approach reconstructs methylation‐informed phylogenies and defines the core epigenome.
Bin Ma, Huimin Gong, Ran Zhuo, Zaixiao Rao, Yanxi Wan, Mingyang Wang, Zahra Zeinalzadeh, Yuan Gao, Aohan Guan, Xinrun Li, Wanting Chen, Xiliang Wang, Yun Wan, Sihua Zhang, Yuncai Xiao, Qi Huang, Paul R. Langford, Xiangru Wang, Rui Zhou, Rui Luo, Hongbo Zhou, Chengliang Zhu, Hui Jin   +22 more
wiley   +1 more source

Large-scale human promoter mapping using CpG islands

, 2000
Vertebrate genomic DNA is generally CpG depleted(1,2), possibly because methylation of cytosines at 80% of CpG dinucleotides results in their frequent mutation to thymine. and thus CpG to TpG dinucleotides(3).
Ilya P. Ioshikhes, Michael Q. Zhang, Ioshikhes, I. P., Zhang, M. Q.   +3 more
core   +1 more source