Results 71 to 80 of about 47,629 (244)
Annals of Neurology, EarlyView.Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello +20 more
wiley +1 more source
Genomic distribution of methylated and unmethylated CpG islands.
, 2013 We subdivided CpG islands into methylated and unmethylated islands and then categorized them into different bins according to their sizes. A. Genomic distribution of methylated CpG islands. B. Genomic distribution of unmethylated CpG islands.
Zhenhui Li (282794) +6 more
core +1 more source
CpG Islands Detector: a Window-based CpG Island Search Tool [PDF]
Genomics & Informatics, 2010 Abstract CpG is the pair of nucleotides C and G, appearing suc-cessively, in this order, along one DNA strand. It is known that due to biochemical considerations CpG is relatively rare in most DNA sequences. However, in par-ticular subsequences, which are a few hundred to a few thousand nucleotides long, the couple CpG is more frequent.
openaire +1 more source
Peripheral blood DNA methylation changes precede lymphoma diagnosis in primary Sjögren's disease
Arthritis &Rheumatology, Accepted Article.Objectives Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of high‐risk patients are lacking.
Hanna Lidberg +2 more
wiley +1 more source
An evaluation of new criteria for CpG islands in the human genome as gene markers [PDF]
, 2004 Motivation: Recently, more stringent criteria for CpG islands have been introduced to exclude Alu repeats, thereby enabling a higher proportion of CpG islands associating with genes to be identified.
Wang, Y, Leung, FCC
core +1 more source
BMC Genomics, 2011 Background Due to its overarching role in genome function, sequence-dependent DNA curvature continues to attract great attention. The DNA double helix is not a rigid cylinder, but presents both curvature and flexibility in different regions, depending on
Jáuregui Ruy +2 more
doaj +1 more source
Predicting aberrant CpG island methylation [PDF]
Proceedings of the National Academy of Sciences, 2003 Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of ...
F A, Feltus +4 more
openaire +2 more sources
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Schematic structures of five candidate genes with six CpG islands.
, 2015 Five candidate genes with six CpG islands were chosen for bisulphite sequencing: Vomeronasal type 2 receptor 64 (Vmn2r64, 2 CpG islands (1 and 2), Olfactory receptor genes 110 (Olfr110) and 601 (Olfr601), Pre-B lymphocyte gene 2 (Vpreb2), and Histone ...
Anni-Maija Linden (206851) +7 more
core +1 more source
PLoS ONE, 2010 BackgroundMethylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in ...
Daisuke Yamamoto +7 more
doaj +1 more source