Results 71 to 80 of about 487,995 (250)

Predicting aberrant CpG island methylation [PDF]

Proceedings of the National Academy of Sciences, 2003
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of
F A, Feltus, E K, Lee, J F, Costello, C, Plass, P M, Vertino   +4 more
openaire   +2 more sources

Chemotherapy‐Activated GSK3β‐DNMT1 Signaling Upregulates CD47 to Evade Macrophage Phagocytosis and Drive Temozolomide Resistance in Glioblastoma

Advanced Science, EarlyView.
Temozolomide treatment activates GSK3β, driving DNMT1 phosphorylation, destabilization, and CD47 promoter hypomethylation in glioblastoma. This epigenetic shift upregulates CD47, enabling TMZ‐treated GBM cells to evade macrophage phagocytosis, survive chemotherapy, and acquire resistance.
Jie Li, Shuai Ying, Yi Zhang, Jingjing Wang, Quan Wan, Lingli Gong, Daxing Xu, Zhenkun Yang, Hongnian Lu, Ying Yin, Xiangming Fang, Zhening Pu   +11 more
wiley   +1 more source

Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes [PDF]

, 2009
DNA oligonucleotides (ODN) applied to an organism are known to modulate the innate and adaptive immune system. Previous studies showed that a CpG-containing ODN (CpG-1-PTO) and interestingly, also a non-CpG-containing ODN (nCpG- 5-PTO) suppress ...
Annette Dorn, Diamant Thaçi, Hofmann, Matthias, Roland Kaufmann, Andreas Bock, Maike Schultz, Thaçi, Diamant, Stefan Kippenberger, Bock, Andreas, Schultz, Maike, Dorn, Annette, Hüseyin Aygün, Kippenberger, Stefan, August Bernd, Matthias Hofmann, Aygün, Hüseyin, Bernd, August, Müller, Jutta, Kaufmann, Roland, Jutta Müller   +19 more
core   +1 more source

Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.

PLoS ONE, 2010
BackgroundMethylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral cancer cell line resulted in ...
Daisuke Yamamoto, Kaori Shima, Kou Matsuo, Takashi Nishioka, Chang Yan Chen, Guo-Fu Hu, Akira Sasaki, Takanori Tsuji   +7 more
doaj   +1 more source

Optimized Cas9‐Enriched Nanopore Sequencing and Analysis Workflow for Clinical Diagnosis of Repeat Expansion Disorders

Advanced Science, EarlyView.
An optimized Cas9‐enriched nanopore sequencing workflow, combined with STRiker, enables simultaneous analysis of disease‐associated STR loci from patient blood. The nCATS–STRiker workflow detects repeat expansions, de novo repeat motifs, interruption patterns, and methylation in a single assay, improving the genetic diagnosis of previously undiagnosed ...
Seungbok Lee, Chanju Jung, Minjeong Kim, Narae Kim, Gue‐Ho Hwang, Soon‐Tae Lee, Kon Chu, Sang Kun Lee, Han‐Joon Kim, Jong‐Hee Chae, Sangsu Bae, Jangsup Moon   +11 more
wiley   +1 more source

Diversity of core promoter elements comprising human bidirectional promoters

BMC Genomics, 2008
Background Bidirectional promoters lie between adjacent genes, which are transcribed from opposite strands of DNA. The functional mechanisms underlying the activation of bidirectional promoters are currently uncharacterised.
Elnitski Laura L, Yang Mary
doaj   +1 more source

In silico enhanced restriction enzyme based methylation analysis of the human glioblastoma genome using Agilent 244K CpG Island microarrays

Frontiers in Neuroscience, 2010
Genome wide methylation profiling of gliomas is likely to provide important clues to improving treatment outcomes. Restriction enzyme based approaches have been widely utilized for methylation profiling of cancer genomes and will continue to have ...
Anh Tran, Anh Tran, Cameron Escovedo, Cameron Escovedo, Justine Migdall-Wilson, Arthur Chou, Weidong Chen, Weidong Chen, Timothy Cloughesy, Timothy Cloughesy, Stanley Nelson, Albert Lai, Albert Lai   +12 more
doaj   +1 more source

From Marginal to Central: Marginal Zone‐like B Cells as Critical Targets in Cladribine‐Treated Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) is a chronic autoimmune disease where B cells play a central pathogenic role. Cladribine, an oral therapy, provides durable benefits by reshaping lymphocyte populations, yet its specific long‐term impact on distinct B‐cell subsets is not fully understood.
Marta Pirronello, Mario Picozza, Gisella Guerrera, Silvia Corbisiero, Andrea Misiti, Roberta C. Placido, Alice Verdiani, Lorenzo de Marco, Manolo Sambucci, Elena Olivieri, Daniela F. Angelini, Esmeralda Quartuccio, Luca Prosperini, Carla Tortorella, Maria C. Buscarinu, Valeria Zancan, Francesca de Masi, Marco Salvetti, Claudio Gasperini, Giovanna Borsellino, Luca Battistini   +20 more
wiley   +1 more source

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns [PDF]

, 2012
: BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes.
Sproul, Duncan, J Michael Dixon, Nestor, Colm E,, Ramsahoye, Bernard H, Nestor, Colm E, Sims, Andrew H, Harrison, David J, Meehan, Richard R,, Sims, Andrew H,, Dixon, J Michael,, David J Harrison, Ramsahoye, Bernard H,, Kitchen, Robert R, Sproul, Duncan,, Meehan, Richard R, Richard R Meehan, Dixon, J Michael, Andrew H Sims, Bernard H Ramsahoye, Robert R Kitchen, Duncan Sproul, Harrison, David J,, Colm E Nestor, Kitchen, Robert R,   +23 more
core   +1 more source

Peripheral Blood DNA Methylation Changes Precede Lymphoma Diagnosis in Primary Sjögren's Disease

Arthritis &Rheumatology, EarlyView.
Objective Primary Sjögren's disease (SjD) is a systemic autoimmune disease associated with an increased risk of lymphoma. The molecular mechanisms underlying lymphomagenesis remain poorly understood, and sensitive biomarkers for early identification of patients at high risk of developing lymphoma are lacking.
Hanna Lidberg, Cecilia Fugmann, Juliana Imgenberg‐Kreuz   +2 more
wiley   +1 more source