Results 51 to 60 of about 71,530 (247)
Locating regions in a sequence under density constraints [PDF]
, 2013 Several biological problems require the identification of regions in a sequence where some feature occurs within a target density range: examples including the location of GC-rich regions, identification of CpG islands, and sequence matching ...
Benjamin A. Burton +5 more
core +3 more sources
BMC Cancer, 2012 Background Many miR genes are located within or around CpG islands. It is unclear whether methylation of these CpG islands represses miR transcription regularly. The aims of this study are to characterize gastric carcinoma (GC)-related methylation of miR
Du Yantao +6 more
doaj +1 more source
Global methylation patterns in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2012 BACKGROUND:Idiopathic Pulmonary Fibrosis (IPF) is characterized by profound changes in the lung phenotype including excessive extracellular matrix deposition, myofibroblast foci, alveolar epithelial cell hyperplasia and extensive remodeling.
Einat I Rabinovich +7 more
doaj +1 more source
Permissive transcriptional activity at the centromere through pockets of DNA hypomethylation. [PDF]
PLoS Genetics, 2006 DNA methylation is a hallmark of transcriptional silencing, yet transcription has been reported at the centromere. To address this apparent paradox, we employed a fully sequence-defined ectopic human centromere (or neocentromere) to investigate the ...
Nicholas C Wong +7 more
doaj +2 more sources
Distributions associated with general runs and patterns in hidden Markov models
, 2007 This paper gives a method for computing distributions associated with patterns in the state sequence of a hidden Markov model, conditional on observing all or part of the observation sequence.
Aston, John A. D., Martin, Donald E. K.
core +1 more source
Cfp1 is required for gene expression dependent H3K4me3 and H3K9 acetylation in embryonic stem cells [PDF]
, 2014 BackgroundTrimethylation of histone H3 lysine 4 (H3K4me3) accumulates at promoters in a gene activity dependent manner. The Set1 complex is responsible for most H3K4me3 in somatic cells and contains the conserved subunit Cfp1, which is implicated in ...
Bird, Adrian +2 more
core +1 more source
Underestimated effect of intragenic HIV-1 DNA methylation on viral transcription in infected individuals [PDF]
, 2020 Background: The HIV-1 proviral genome harbors multiple CpG islands (CpGIs), both in the promoter and intragenic regions. DNA methylation in the promoter region has been shown to be heavily involved in HIV-1 latency regulation in cultured cells.
De Meyer, Tim +7 more
core +2 more sources
Epigenetics, 2011 The majority of mammalian gene promoters are encompassed within regions of the genome called CpG islands that have an elevated level of non-methylated CpG dinucleotides. Despite over 20 years of study, the precise mechanisms by which CpG islands contribute to regulatory element function remain poorly understood.
Blackledge, N, Klose, R
openaire +2 more sources
Identification of CpG islands using a bank of IIR lowpass filters [PDF]
, 2004 It has been known that biological sequences such as the DNA sequence display different kinds of patterns depending on their biological functions. This statistical difference can be exploited for identifying the region of interest, such as the protein ...
Vaidyanathan, P. P., Yoon, Byung-Jun
core
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source