Results 31 to 40 of about 71,530 (247)

CpG islands and the regulation of transcription [PDF]

Genes & Development, 2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters.
Deaton, Aimee M., Bird, Adrian; id_orcid 0000-0002-8600-0372   +1 more
openaire   +3 more sources

Prediction of CpG-island function: CpG clustering vs. sliding-window methods

BMC Genomics, 2010
Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as
Luque-Escamilla Pedro L, Carpena Pedro, Barturen Guillermo, Hackenberg Michael, Previti Christopher, Oliver José L   +5 more
doaj   +1 more source

Expression and regulatory effects on cancer cell behavior of NELL1 and NELL2 in human renal cell carcinoma [PDF]

, 2015
We thank Professors Michael Rehli, Yoshiaki Ito, and Kristian Helin for gifting plasmids, Dr. Alasdair MacKenzie (University of Aberdeen) for helpful discussion, and Mr. Takashi Mizukami, Ms. Ryoko Tokuda, and Ms.
Mizokami, Atsushi, Nakamoto, Masaru, Nakamura, Ritsuko, Namiki, Mikio, Ooi, Akishi, Oyama, Takeru, Tajiri, Ryosuke   +6 more
core   +1 more source

Evolution of CpG-islands by means of tandem duplications

Вавиловский журнал генетики и селекции, 2017
CG-rich islands (CpG-islands, or CGI) are important functional elements in a genome of vertebrates. In particular, they: a) initiate transcription as promoters in most (> 50 %) genes of vertebrates, in some cases bi-directional, due to self-complement
V. N. Babenko, Y. L. Orlov, Zh. T. Isakova, D. A. Antonov, M. I. Voevoda   +4 more
doaj   +1 more source

Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. [PDF]

PLoS ONE, 2012
BACKGROUND: The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we characterized the nucleosome position within the p16 CpG island ...
Zhe-Ming Lu, Jing Zhou, Xiuhong Wang, Zhenpo Guan, Hua Bai, Zhao-Jun Liu, Na Su, Kaifeng Pan, Jiafu Ji, Dajun Deng   +9 more
doaj   +1 more source

Mining and Predicting CpG islands [PDF]

2007 IEEE International Fuzzy Systems Conference, 2007
A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G).
Christopher Previti, Oscar Harari, Coral del Val   +2 more
openaire   +1 more source

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]

PLoS Genetics, 2007
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, Jingmin Shu, Xinli Chen, Robert A Waterland, Jean-Pierre J Issa   +9 more
doaj   +1 more source

Genetic recombination is targeted towards gene promoter regions in dogs [PDF]

, 2013
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton, Adam R Boyko, Carlos D Bustamante, J Kim Holloway, Jeffrey Kidd, Jessica J Hayward, John M Greally, Julie Nadel, Jun Wang, Jun Wang, Kyle Oliveira, Paula E Cohen, Ying Rui Li   +12 more
core   +4 more sources

GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences

BMC Genomics, 2017
Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu, Xuan Guo, Alexander Zelikovsky, Yi Pan   +3 more
doaj   +1 more source

Preservation of methylated CpG dinucleotides in human CpG islands [PDF]

Biology Direct, 2016
CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Panchin, Alexander Y., Makeev, Vsevolod J., Medvedeva, Yulia A.   +2 more
openaire   +2 more sources