Results 31 to 40 of about 487,995 (250)

Inhibitory effect of alpinetin on IL‐6 expression by promoting cytosine methylation in CpG islands in the IL‐6 promoter region

Molecular Genetics & Genomic Medicine, 2020
Background Alpinetin is a flavonoid which exerts antibacterial and anti‐inflammatory functions. In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin‐6 (IL‐6)
Ke Hu, Yuxian Li, Minghua Liang, Lijing Liu, Yuefu Chen, Minjiang Huang, Bifeng Tan, Yingquan Luo, Huiming Yin   +8 more
doaj   +1 more source

Mining and Predicting CpG islands [PDF]

2007 IEEE International Fuzzy Systems Conference, 2007
A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G).
Christopher Previti, Oscar Harari, Coral del Val   +2 more
openaire   +2 more sources

GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences

BMC Genomics, 2017
Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu, Xuan Guo, Alexander Zelikovsky, Yi Pan   +3 more
doaj   +1 more source

Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]

PLoS ONE, 2014
DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song, Yongzhe Liu, Ying Liu, Cong Zhang, Bao Yuan, Lianbo Zhang, Shilong Sun   +6 more
doaj   +1 more source

An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits

Frontiers in Genetics, 2019
Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research.
Xiao Wang, Haja N. Kadarmideen
doaj   +1 more source

Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]

PLoS Genetics, 2007
The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen, Yutaka Kondo, Yi Guo, Jiexin Zhang, Li Zhang, Saira Ahmed, Jingmin Shu, Xinli Chen, Robert A Waterland, Jean-Pierre J Issa   +9 more
doaj   +1 more source

Preservation of methylated CpG dinucleotides in human CpG islands [PDF]

Biology Direct, 2016
CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Panchin, Alexander Y., Makeev, Vsevolod J., Medvedeva, Yulia A.   +2 more
openaire   +2 more sources

DNA methylation changes in ovarian cancer are cumulative with disease progression and identify tumor stage

BMC Medical Genomics, 2008
Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.
DeGeest Koen, Holtan Nicholas, Futscher Bernard W, Watts George S, Domann Frederick E, Rose Stephen L   +5 more
doaj   +1 more source

In Vivo Control of CpG and Non-CpG DNA Methylation by DNA Methyltransferases [PDF]

, 2012
The enzymatic control of the setting and maintenance of symmetric and non-symmetric DNA methylation patterns in a particular genome context is not well understood.
Julia Arand (155279), Meissner, A, Meilinger, D., Arand, Julia, Leonhardt, Heinrich, Jenuwein, Thomas, Wolf, Verena, Thomas Jenuwein (70681), Tommy Karius, David Spieler, Jenuwein, T., Xu, G, Tommy Karius (155285), Walter, Jörn, Wolf, V., Branco, MR, Leonhardt, H, Spieler, D, Branco, Miguel R., Meilinger, Daniela, Julia Arand, Jörn Walter, Walter, Joern, Jörn Walter (37094), Walter, J, Miguel R. Branco (42502), Verena Wolf, Karius, T, Meissner, Alexander, Arand, J, Alexander Meissner (11643), Meilinger, D, Daniela Meilinger, Heinrich Leonhardt (18589), Verena Wolf (155286), Daniela Meilinger (107843), Arand, J., Jenuwein, T, Miguel R Branco, Thomas Jenuwein, Guoliang Xu, Alexander Meissner, Walter, J., Meissner, A., Heinrich Leonhardt, Karius, Tommy, Guoliang Xu (67200), Spieler, David, Karius, T., Xu, Guoliang, David Spieler (155282), Branco, M., Xu, G., Wolf, V, Spieler, D., Leonhardt, H.   +55 more
core   +1 more source

Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. [PDF]

PLoS Genetics, 2012
We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands.
Altuna Akalin, Francine E Garrett-Bakelman, Matthias Kormaksson, Jennifer Busuttil, Lu Zhang, Irina Khrebtukova, Thomas A Milne, Yongsheng Huang, Debabrata Biswas, Jay L Hess, C David Allis, Robert G Roeder, Peter J M Valk, Bob Löwenberg, Ruud Delwel, Hugo F Fernandez, Elisabeth Paietta, Martin S Tallman, Gary P Schroth, Christopher E Mason, Ari Melnick, Maria E Figueroa   +21 more
doaj   +1 more source