Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. [PDF]
PLoS Genetics, 2007 The role of CpG island methylation in normal development and cell differentiation is of keen interest, but remains poorly understood. We performed comprehensive DNA methylation profiling of promoter regions in normal peripheral blood by methylated CpG ...
Lanlan Shen +9 more
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GaussianCpG: a Gaussian model for detection of CpG island in human genome sequences
BMC Genomics, 2017 Background As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome ...
Ning Yu +3 more
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Preservation of methylated CpG dinucleotides in human CpG islands [PDF]
Biology Direct, 2016 CpG dinucleotides are extensively underrepresented in mammalian genomes. It is widely accepted that genome-wide CpG depletion is predominantly caused by an elevated CpG > TpG mutation rate due to frequent cytosine methylation in the CpG context. Meanwhile the CpG content in genomic regions called CpG islands (CGIs) is noticeably higher.
Panchin, Alexander Y. +2 more
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An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits
Frontiers in Genetics, 2019 Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research.
Xiao Wang, Haja N. Kadarmideen
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Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]
PLoS ONE, 2014 DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song +6 more
doaj +1 more source
BMC Medical Genomics, 2008 Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.
DeGeest Koen +5 more
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Signal Processing Methods for Genomic Sequence Analysis [PDF]
, 2007 Signal processing is the art of representing, transforming, analyzing, and manipulating signals. It deals with a wide range of signals, from speech and audio signals to images and video signals, and many others.
Yoon, Byung-Jun
core +1 more source
Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. [PDF]
PLoS Genetics, 2012 We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands.
Altuna Akalin +21 more
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Links between DNA methylation and nucleosome occupancy in the human genome
Epigenetics & Chromatin, 2017 Background DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator of high nucleosome occupancy has ...
Clayton K. Collings, John N. Anderson
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Chicken microchromosomes are hyperacetylated, early replicating, and gene rich
, 1998 The chicken karyotype consists of 39 chromosomes of which 33 are classed as microchromosomes (MICs). MICs contain about one third of genomic DNA. The majority of mapped chicken genes are assigned to macrochromosomes (MACs), but a recent study indicated ...
Heather A. McQueen +5 more
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