Results 21 to 30 of about 487,995 (250)

DNA methylation in follicular lymphoma [PDF]

, 2010
PhDFollicular Lymphoma (FL) is a common B cell Non-Hodgkin Lymphoma with a median survival of 8-10 years. Patients frequently undergo transformation to a more aggressive lymphoma and this is associated with drastically reduced survival.
Ó Riain, Ciarán Liam
core   +4 more sources

Intergenic, gene terminal, and intragenic CpG islands in the human genome

BMC Genomics, 2010
Background Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied.
Kulakovskiy Ivan V, Ermakova Ekaterina O, Malko Dmitry B, Oparina Nina J, Fridman Marina V, Medvedeva Yulia A, Heinzel Andreas, Makeev Vsevolod J   +7 more
doaj   +1 more source

Orphan CpG islands identify numerous conserved promoters in the mammalian genome [PDF]

, 2010
This work was funded by grants from the Wellcome Trust (077224; http://www.wellcome.ac.uk/) and the Medical Research Council (G0800026; http:// www.mrc.ac.uk/index.htm).CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of ...
Gruenewald-Schneider, Ulrike, Shaun Webb, Bird, A.P.; id_orcid, Webb, Shaun, Smith Colin, Kerr, A.R.W., Andrews, Robert, Keith D James, Daniel J. Turner, Turner, D.J., Webb, S., James, Keith D., James, K.D., Robert S Illingworth, Robert Andrews, Webb Shaun, Smith, Colin; id_orcid, Keith D. James, Harrison David J., David J. Harrison, Alastair R. W. Kerr, Bird, Adrian P., Gruenewald-Schneider, U., Gruenewald-Schneider Ulrike, Turner Daniel J., Andrews, R., Smith, Colin, Illingworth Robert S., Turner, Daniel J., Illingworth, Robert S., Ulrike Gruenewald-Schneider, David J Harrison, Bird Adrian P., Robert S. Illingworth, Alastair R W Kerr, Colin Smith, Andrews Robert, Kerr, Alastair R. W., Illingworth, R.S., Kerr Alastair R. W., Harrison, D.J., Daniel J Turner, James Keith D., Adrian P. Bird, Harrison, David J., Adrian P Bird   +45 more
core   +1 more source

CpG islands – ‘A rough guide’ [PDF]

FEBS Letters, 2009
Mammalian genomes are punctuated by DNA sequences containing an atypically high frequency of CpG sites termed CpG islands (CGIs). CGIs generally lack DNA methylation and associate with the majority of annotated gene promoters. Many studies, however, have identified examples of CGI methylation in malignant cells, leading to improper gene silencing.
Illingworth, Robert S., Bird, Adrian P.
openaire   +2 more sources

Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the human genome.

PLoS ONE, 2007
BackgroundMajority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is
Shicai Fan, Fang Fang, Xuegong Zhang, Michael Q Zhang   +3 more
doaj   +1 more source

Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]

PLoS ONE, 2012
DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek, Clemens Wrzodek, Finja Büchel, Georg Hinselmann, Johannes Eichner, Florian Mittag, Andreas Zell   +6 more
doaj   +1 more source

CpG islands and the regulation of transcription [PDF]

Genes & Development, 2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters.
Aimée M, Deaton, Adrian, Bird
openaire   +2 more sources

Prediction of CpG-island function: CpG clustering vs. sliding-window methods

BMC Genomics, 2010
Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as
Luque-Escamilla Pedro L, Carpena Pedro, Barturen Guillermo, Hackenberg Michael, Previti Christopher, Oliver José L   +5 more
doaj   +1 more source

Evolution of CpG-islands by means of tandem duplications

Вавиловский журнал генетики и селекции, 2017
CG-rich islands (CpG-islands, or CGI) are important functional elements in a genome of vertebrates. In particular, they: a) initiate transcription as promoters in most (> 50 %) genes of vertebrates, in some cases bi-directional, due to self-complement
V. N. Babenko, Y. L. Orlov, Zh. T. Isakova, D. A. Antonov, M. I. Voevoda   +4 more
doaj   +1 more source

Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. [PDF]

PLoS ONE, 2012
BACKGROUND: The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we characterized the nucleosome position within the p16 CpG island ...
Zhe-Ming Lu, Jing Zhou, Xiuhong Wang, Zhenpo Guan, Hua Bai, Zhao-Jun Liu, Na Su, Kaifeng Pan, Jiafu Ji, Dajun Deng   +9 more
doaj   +1 more source