Results 21 to 30 of about 71,530 (247)
A Hybrid Approach for CpG Island Detection in the Human Genome. [PDF]
PLoS ONE, 2016 BACKGROUND:CpG islands have been demonstrated to influence local chromatin structures and simplify the regulation of gene activity. However, the accurate and rapid determination of CpG islands for whole DNA sequences remains experimentally and ...
Cheng-Hong Yang +3 more
doaj +1 more source
Intergenic, gene terminal, and intragenic CpG islands in the human genome
BMC Genomics, 2010 Background Recently, it has been discovered that the human genome contains many transcription start sites for non-coding RNA. Regulatory regions related to transcription of this non-coding RNAs are poorly studied.
Kulakovskiy Ivan V +7 more
doaj +1 more source
Within-pair differences of DNA methylation levels between monozygotic twins are different between male and female pairs [PDF]
, 2016 BACKGROUND: DNA methylation levels will be important for detection of epigenetic effects. However, there are few reports showing sex-related differences in the sensitivity to DNA methylation.
Chika Honda +14 more
core +1 more source
Histone methylation marks play important roles in predicting the methylation status of CpG islands [PDF]
, 2008 The methylation status of CpG islands is highly correlated with gene expression. Current methods for computational prediction of DNA methylation only utilize DNA sequence features.
Fan, S., Zhang, M. Q., Zhang, X.
core +1 more source
Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]
, 2014 Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation.
Capra, John A., Kostka, Dennis
core +1 more source
DNA methylation and chromatin structure: The puzzling CpG islands [PDF]
, 2005 DNA methylation is the epigenetic modification,which introduces 5mC as fifth base onto DNA. As for the distribution of 5rnCs, it is well known that they distribute themselves in a non-random fashion in genomic DNA so that methylation pattern is ...
CAIAFA, Paola, ZAMPIERI, Michele
core +1 more source
PLoS ONE, 2007 BackgroundMajority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is
Shicai Fan +3 more
doaj +1 more source
Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]
PLoS ONE, 2012 DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek +6 more
doaj +1 more source
Sex differences in DNA methylation assessed by 450 K BeadChip in newborns. [PDF]
, 2015 BackgroundDNA methylation is an important epigenetic mark that can potentially link early life exposures to adverse health outcomes later in life.
Barcellos, Lisa +5 more
core +1 more source