Results 21 to 30 of about 47,629 (244)

A Hybrid Approach for CpG Island Detection in the Human Genome. [PDF]

PLoS ONE, 2016
BACKGROUND:CpG islands have been demonstrated to influence local chromatin structures and simplify the regulation of gene activity. However, the accurate and rapid determination of CpG islands for whole DNA sequences remains experimentally and ...
Cheng-Hong Yang, Yu-Da Lin, Yi-Cheng Chiang, Li-Yeh Chuang   +3 more
doaj   +1 more source

Orphan CpG islands identify numerous conserved promoters in the mammalian genome [PDF]

, 2010
This work was funded by grants from the Wellcome Trust (077224; http://www.wellcome.ac.uk/) and the Medical Research Council (G0800026; http:// www.mrc.ac.uk/index.htm).CpG islands (CGIs) are vertebrate genomic landmarks that encompass the promoters of ...
Gruenewald-Schneider, Ulrike, Shaun Webb, Bird, A.P.; id_orcid, Webb, Shaun, Smith Colin, Kerr, A.R.W., Andrews, Robert, Keith D James, Daniel J. Turner, Turner, D.J., Webb, S., James, Keith D., James, K.D., Robert S Illingworth, Robert Andrews, Webb Shaun, Smith, Colin; id_orcid, Keith D. James, Harrison David J., David J. Harrison, Alastair R. W. Kerr, Bird, Adrian P., Gruenewald-Schneider, U., Gruenewald-Schneider Ulrike, Turner Daniel J., Andrews, R., Smith, Colin, Illingworth Robert S., Turner, Daniel J., Illingworth, Robert S., Ulrike Gruenewald-Schneider, David J Harrison, Bird Adrian P., Robert S. Illingworth, Alastair R W Kerr, Colin Smith, Andrews Robert, Kerr, Alastair R. W., Illingworth, R.S., Kerr Alastair R. W., Harrison, D.J., Daniel J Turner, James Keith D., Adrian P. Bird, Harrison, David J., Adrian P Bird   +45 more
core   +1 more source

CpG Islands in feature 120.

, 2022
List of CpG Islands agglomerated in F120, therefore assigned to the highest effect weight.
Michela Carlotta Massi (9122257), Giovanni Fiorito (136942), Lorenzo Dominoni (13864268), Francesca Ieva (144652)   +3 more
core   +1 more source

Putative zinc finger protein binding sites are over-represented in the boundaries of methylation-resistant CpG islands in the human genome.

PLoS ONE, 2007
BackgroundMajority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is
Shicai Fan, Fang Fang, Xuegong Zhang, Michael Q Zhang   +3 more
doaj   +1 more source

Linking the epigenome to the genome: correlation of different features to DNA methylation of CpG islands. [PDF]

PLoS ONE, 2012
DNA methylation of CpG islands plays a crucial role in the regulation of gene expression. More than half of all human promoters contain CpG islands with a tissue-specific methylation pattern in differentiated cells.
Clemens Wrzodek, Clemens Wrzodek, Finja Büchel, Georg Hinselmann, Johannes Eichner, Florian Mittag, Andreas Zell   +6 more
doaj   +1 more source

CpG islands and the regulation of transcription [PDF]

Genes & Development, 2011
Vertebrate CpG islands (CGIs) are short interspersed DNA sequences that deviate significantly from the average genomic pattern by being GC-rich, CpG-rich, and predominantly nonmethylated. Most, perhaps all, CGIs are sites of transcription initiation, including thousands that are remote from currently annotated promoters.
Deaton, Aimee M., Bird, Adrian; id_orcid 0000-0002-8600-0372   +1 more
openaire   +3 more sources

Prediction of CpG-island function: CpG clustering vs. sliding-window methods

BMC Genomics, 2010
Background Unmethylated stretches of CpG dinucleotides (CpG islands) are an outstanding property of mammal genomes. Conventionally, these regions are detected by sliding window approaches using %G + C, CpG observed/expected ratio and length thresholds as
Luque-Escamilla Pedro L, Carpena Pedro, Barturen Guillermo, Hackenberg Michael, Previti Christopher, Oliver José L   +5 more
doaj   +1 more source

Nucleosomes correlate with in vivo progression pattern of de novo methylation of p16 CpG islands in human gastric carcinogenesis. [PDF]

PLoS ONE, 2012
BACKGROUND: The exact relationship between nucleosome positioning and methylation of CpG islands in human pathogenesis is unknown. METHODOLOGY/PRINCIPAL FINDINGS: In the present study, we characterized the nucleosome position within the p16 CpG island ...
Zhe-Ming Lu, Jing Zhou, Xiuhong Wang, Zhenpo Guan, Hua Bai, Zhao-Jun Liu, Na Su, Kaifeng Pan, Jiafu Ji, Dajun Deng   +9 more
doaj   +1 more source

Mining and Predicting CpG islands [PDF]

2007 IEEE International Fuzzy Systems Conference, 2007
A DNA sequence can be described as a string composed of four symbols: A, T, C and G. Each symbol represents a chemically distinct nucleotide molecule. Combinations of two nucleotides are called dinucleotides and CpG islands represent regions of a DNA sequence, certain substrings, which are enriched in CpG dinucleotides (C followed by G).
Christopher Previti, Oscar Harari, Coral del Val   +2 more
openaire   +1 more source

Inhibitory effect of alpinetin on IL‐6 expression by promoting cytosine methylation in CpG islands in the IL‐6 promoter region

Molecular Genetics & Genomic Medicine, 2020
Background Alpinetin is a flavonoid which exerts antibacterial and anti‐inflammatory functions. In order to prove that the induced methylation is an important mechanism for alpinetin in regulating the expression of inflammatory factor Interleukin‐6 (IL‐6)
Ke Hu, Yuxian Li, Minghua Liang, Lijing Liu, Yuefu Chen, Minjiang Huang, Bifeng Tan, Yingquan Luo, Huiming Yin   +8 more
doaj   +1 more source