An Epigenome-Wide DNA Methylation Map of Testis in Pigs for Study of Complex Traits
Frontiers in Genetics, 2019 Epigenetic changes are important for understanding complex trait variation and inheritance in pigs that are also a valuable biomedical model for human health research.
Xiao Wang, Haja N. Kadarmideen
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Increased p16 DNA methylation in mouse thymic lymphoma induced by irradiation. [PDF]
PLoS ONE, 2014 DNA methylation is an important part of epigenetics. In this study, we examined the methylation state of two CpG islands in the promoter of the p16 gene in radiation-induced thymic lymphoma samples.
Wengang Song +6 more
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Assessing the preservation of cytosine methylation in ancient DNA from five prehistoric Native American populations [PDF]
, 2015 textCytosine methylation of CpG dinucleotides is an important epigenetic mark that regulates gene expression in humans. While methylation patterns in extant populations have been widely studied, few studies have attempted to analyze methylation in ...
Smith, Ricky Wayne Aldon
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BMC Medical Genomics, 2008 Background Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.
DeGeest Koen +5 more
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Comparative (computational) analysis of the DNA methylation status of trinucleotide repeat expansion diseases [PDF]
, 2013 Copyright © 2013 Mohammadmersad Ghorbani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is ...
Ghorbani, M +3 more
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Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia. [PDF]
PLoS Genetics, 2012 We have developed an enhanced form of reduced representation bisulfite sequencing with extended genomic coverage, which resulted in greater capture of DNA methylation information of regions lying outside of traditional CpG islands.
Altuna Akalin +21 more
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Comprehensive methylome map of lineage commitment from haematopoietic progenitors. [PDF]
, 2010 Epigenetic modifications must underlie lineage-specific differentiation as terminally differentiated cells express tissue-specific genes, but their DNA sequence is unchanged.
Aryee, Martin J +17 more
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Links between DNA methylation and nucleosome occupancy in the human genome
Epigenetics & Chromatin, 2017 Background DNA methylation is an epigenetic modification that is enriched in heterochromatin but depleted at active promoters and enhancers. However, the debate on whether or not DNA methylation is a reliable indicator of high nucleosome occupancy has ...
Clayton K. Collings, John N. Anderson
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DNA methylation and DNA methyltransferases [PDF]
, 2017 The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H +3 more
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Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
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