Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities
MedComm – Oncology, Volume 5, Issue 2, June 2026.Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu +3 more
wiley +1 more source
SOX1/PAX1 Methylation for Triage of HPV‐Positive Women in Cervical Cancer Screening: A Cohort Study
BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 7, Page 1431-1440, June 2026.ABSTRACT Objective To establish a better triage strategy using SOX1/PAX1 methylation detection for high‐risk HPV (hrHPV)‐positive women than cytology. Design A cohort study. Setting Population‐based cervical cancer (CC) screening cohort. Population A total of 5684 women were enrolled.
Hongyu Xie +6 more
wiley +1 more source
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain. [PDF]
Nucleic Acids Res, 2023 Weber LM +16 more
europepmc +1 more source
Insect Molecular Biology, Volume 35, Issue 3, Page 232-245, June 2026.Comparison between developmental stages (larvae, pupae, worker) in Pogonomyrmex californicus revealed significant stage‐specific differences in Gene Body Methylated frequencies. Methylation sites were highly correlated between WGBS and ONT in P. californicus Genome‐wide methylation was low (~3%) and highly clustered within gene bodies (GBM), especially
Tania Chavarria‐Pizarro +4 more
wiley +1 more source
Sequence determinants, function, and evolution of CpG islands. [PDF]
Biochem Soc Trans, 2021 Angeloni A, Bogdanovic O.
europepmc +1 more source
International Journal of Cancer, Volume 158, Issue 10, Page 2530-2536, 15 May 2026.What's New? The DNA methylation‐based WID‐qEC test has been validated for the accurate detection of endometrial and cervical cancers using cervico‐vaginal samples. However, a small proportion of women test positive despite the absence of these cancers. This study explored the associated biological and clinical characteristics to inform potential follow‐
Elisa Redl +18 more
wiley +1 more source
Profiling ascidian promoters as the primordial type of vertebrate promoter
BMC Genomics, 2011 Background CpG islands are observed in mammals and other vertebrates, generally escape DNA methylation, and tend to occur in the promoters of widely expressed genes.
Okamura Kohji +6 more
doaj +1 more source
DNMT3B overexpression downregulates genes with CpG islands, common motifs, and transcription factor binding sites that interact with DNMT3B. [PDF]
Sci Rep, 2022 Loaeza-Loaeza J +6 more
europepmc +1 more source
Do all colorectal mucinous adenocarcinomas arise via the serrated neoplasia pathway?
The Journal of Pathology: Clinical Research, Volume 12, Issue 3, May 2026.Abstract Colorectal mucinous adenocarcinomas (MACs) and serrated adenocarcinomas (SACs) demonstrate considerable overlap in morphological and molecular features, suggesting a spectrum rather than two distinct tumour types. This study investigates the presence of serrated morphological features, precursors, and molecular features in a large cohort of ...
Anne‐Marie Vos +7 more
wiley +1 more source
CMIC: predicting DNA methylation inheritance of CpG islands with embedding vectors of variable-length k-mers. [PDF]
BMC Bioinformatics, 2022 Maruyama O +5 more
europepmc +1 more source