Results 151 to 160 of about 71,530 (247)
Dysregulation of the PATZ1/CTCF Balance Silences ZBTB20 to Drive Melanoma Progression
Advanced Science, Volume 13, Issue 26, 8 May 2026.This study uncovers a new oncogenic mechanism in melanoma. The transcription factor PATZ1 competes with the architectural protein CTCF for DNA binding, thereby disrupting a specific chromatin loop and silencing the tumor suppressor ZBTB20. This event unleashes the pro‐tumorigenic PMEPA1‐p38‐STAT1 signaling axis, promoting cancer progression.
Chaowei Deng +8 more
wiley +1 more source
Loss of EphA7 Expression in Basal Cell Carcinoma by Hypermethylation of CpG Islands in the Promoter Region. [PDF]
Anal Cell Pathol (Amst), 2022 Liu J +6 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Advanced Science, Volume 13, Issue 27, 13 May 2026.This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen +11 more
wiley +1 more source
Profiling selective binding to promoter CpG islands by a single-DNA mechanical footprinting assay. [PDF]
Biophys J, 2021 Huang W, Yan J.
europepmc +1 more source
American Journal of Medical Genetics Part A, Volume 200, Issue 5, Page 1098-1104, May 2026.ABSTRACT The KDM2B‐related neurodevelopmental disorder is a recently identified Mendelian disorder of the epigenetic machinery associated with pathogenic variants in KDM2B. Global developmental delay, intellectual disability, congenital anomalies, and systemic manifestations characterize the disorder.
Adriana Gomes +3 more
wiley +1 more source
Misexpression of genes lacking CpG islands drives degenerative changes during aging. [PDF]
Sci Adv, 2021 Lee JY +7 more
europepmc +1 more source
Development and validation of MethylCog, a blood DNA methylation proxy for cognition
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract INTRODUCTION Heterogeneity in cognitive ability increases with age and predicts mild cognitive impairment (MCI) and dementia, but scalable blood‐based biomarkers are lacking. We developed and validated MethylCog, a parsimonious DNA methylation (DNAm) marker of general cognitive ability (g).
Deirdre M. O'Shea +9 more
wiley +1 more source
Cancer Medicine, Volume 15, Issue 5, May 2026.In patients with resectable ESCC, DNA hypomethylation driven RELB overexpression promotes resistance to perioperative immunotherapy (neoadjuvant ICIs followed by surgery and adjuvant ICIs). High RELB expression correlates with increased infiltration of mature immunoregulatory dendritic cells (mregDCs) and regulatory T cells (Tregs) in the tumor ...
Lijuan Gao, Shaobo Ke
wiley +1 more source