Results 151 to 160 of about 47,629 (244)

Remodelling the tumour microenvironment and beyond: ERO1A as a multifaceted regulator and emerging therapeutic target in cancer

open access: yesClinical and Translational Medicine, Volume 16, Issue 7, July 2026.
ERO1A exhibits oncogenic functions, including promoting tumour progression, metastasis, epithelial‒mesenchymal transition, angiogenesis, immune evasion and metabolic reprogramming. ERO1A is also identified as a diagnostic biomarker and a factor contributing to therapy resistance (chemotherapy and immunotherapy).
Jing Mao, Kai Wang
wiley   +1 more source

Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives

open access: yesMedComm, Volume 7, Issue 7, July 2026.
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen   +6 more
wiley   +1 more source

Computational analysis of CpG site DNA methylation [PDF]

open access: yes, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Epigenetics is the study of factors that can change DNA and passed to next generation without change to DNA sequence.
Ghorbani, Mohammadmersad
core  

CD8+ Tissue‐Resident Memory T Cells in Health and Disease

open access: yesMedComm, Volume 7, Issue 7, July 2026.
CD8+ TRM cells are at the center of immunity, mediating potent local innate and adaptive immune responses. While TRM cells mediate protective immunity against infections and tumors, they also contribute to pathological inflammation in autoimmune conditions.
Yu‐Han Ai   +13 more
wiley   +1 more source

HOX Gene Promoter Prediction and Inter-genomic Comparison: An Evo-Devo Study

open access: yesJournal of Tropical Life Science, 2010
Homeobox genes direct the anterior-posterior axis of the body plan in eukaryotic organisms. Promoter regions upstream of the Hox genes jumpstart the transcription process.
Marla A. Endriga   +4 more
doaj  

Epigenetic Regulation of Immune Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome

open access: yesThe Prostate, Volume 86, Issue 10, Page 1124-1133, July 2026.
ABSTRACT Background Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent and debilitating condition with unclear etiology. Increasing evidence implicates immune dysregulation, yet the molecular mechanisms underlying impaired immune regulation remain poorly defined. This study investigated the role of altered immune responses within
Praveen Thumbikat   +8 more
wiley   +1 more source

Identification of SNPs Associated With mRNA Expression Differences of the Complement Receptor Type 1‐Like Gene in Landrace Weaned Piglets

open access: yesVeterinary Medicine and Science, Volume 12, Issue 4, July 2026.
ABSTRACT Objective The aim of this study is to investigate the association between single nucleotide polymorphisms (SNPs) of porcine complement receptor 1‐like (CR1‐like) gene and its mRNA expression. Methods SNP identification, qRT‐PCR absolute quantification, linkage disequilibrium analysis and dual‐luciferase reporter assay were performed using 392 ...
Wei Yin   +9 more
wiley   +1 more source

EasyCen: A Lightweight Framework for Centromere Localisation and Repeat‐Organisation Profiling in Telomere‐to‐Telomere Genomes

open access: yesMolecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Accurate identification of centromeres in telomere‐to‐telomere (T2T) genomes remains difficult due to the rapid evolution of centromeric repeats and their lack of conserved sequence features. In this study, we present EasyCen, a lightweight sequence‐based framework for centromere identification and repeat‐architecture profiling across various ...
Yunyun Lv, Yanping Li, Jia Li, Xidong Mu
wiley   +1 more source

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