Results 181 to 190 of about 71,530 (247)

SLA2 is Associated With Immune evasion and Exhaustion of CD8+ T Cells in Gastric Cancer

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT The Src‐like adaptor 2 (SLA2) functions as a negative regulator of T cell receptor signalling. However, its involvement in the tumour microenvironment (TME) of gastric cancer (GC) remains unexplored. In this study, we found that SLA2 expression was significantly elevated in GC tissues, and a high level of SLA2 was associated with poor ...
Yujia Zhang, Xiaoyan Li, Rongchao Xiang
wiley   +1 more source

Roles of transposable elements and DNA methylation in the formation of CpG islands and CpG-depleted regulatory elements. [PDF]

Proc Natl Acad Sci U S A
You JS, Pierce S, Liang G, Jones PA.
europepmc   +1 more source

Epigenetic analyses suggest different pathways during pregnancy for development of type 1 diabetes in children with high versus low‐neutral human leukocyte antigen‐risk

Journal of Internal Medicine, Volume 299, Issue 5, Page 570-586, May 2026.
Abstract Background and objective The development of Type 1 diabetes (T1D) is shaped by genetic predisposition and epigenetic regulation. Human leukocyte antigen (HLA) risk alleles are major genetic determinants, but the epigenetic landscape in relation to disease onset remains unclear.
Shamila D. Alipoor, Angelica Ahrens, Julia Åkesson, Thomas Hillerton, Mika Gustafsson, Maria Lerm, Johnny Ludvigsson   +6 more
wiley   +1 more source

The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. [PDF]

Sci Adv, 2021
Stielow B, Zhou Y, Cao Y, Simon C, Pogoda HM, Jiang J, Ren Y, Phanor SK, Rohner I, Nist A, Stiewe T, Hammerschmidt M, Shi Y, Bulyk ML, Wang Z, Liefke R.   +15 more
europepmc   +1 more source

Phylo-Epigenetic Conservation and CpG Erosion in <i>OCT4</i>, <i>SOX2</i>, and <i>hTERT</i> Intragenic CpG Islands: A Waddingtonian Perspective on Mammalian Developmental Evolution. [PDF]

Genes (Basel)
Santourlidis S.
europepmc   +1 more source

DNA Methylation Profile Changes in CpG Islands of Ethylene-Signaling Genes Regulated by Melatonin Were Involved in Alleviating Chilling Injury of Postharvest Tomato Fruit. [PDF]

Int J Mol Sci
Yan J, Shan S, Li J, Zhang Z, Yang J, Zhang W, Song H, Xu X, Duan W.   +8 more
europepmc   +1 more source

Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands. [PDF]

Nat Genet, 2021
Weinberg DN, Rosenbaum P, Chen X, Barrows D, Horth C, Marunde MR, Popova IK, Gillespie ZB, Keogh MC, Lu C, Majewski J, Allis CD.   +11 more
europepmc   +1 more source

DNA methylation profiling of CpG islands in trigeminal ganglion of rats with orofacial pain induced by experimental tooth movement. [PDF]

BMC Oral Health
Zhu Y, Gu L, Wang J, Han J, Gou J, Wu Z.
europepmc   +1 more source

Neuron-specific chromatin disruption at CpG islands and aging-related regions in Kabuki syndrome mice. [PDF]

Genome Res
Boukas L, Luperchio TR, Razi A, Hansen KD, Bjornsson HT.   +4 more
europepmc   +1 more source

A Method for Identification of the Methylation Level of CpG Islands From NGS Data. [PDF]

Sci Rep, 2020
Uroshlev LA, Abdullaev ET, Umarova IR, Il'icheva IA, Panchenko LA, Polozov RV, Kondrashov FA, Nechipurenko YD, Grokhovsky SL.   +8 more
europepmc   +1 more source