Results 1 to 10 of about 5,254 (231)

Osteogenic CpG Oligodeoxynucleotide, iSN40, Inhibits Osteoclastogenesis in a TLR9-Dependent Manner [PDF]

Life
A CpG oligodeoxynucleotide (CpG-ODN), iSN40, was originally identified as promoting the mineralization and differentiation of osteoblasts, independent of Toll-like receptor 9 (TLR9).
Rena Ikeda, Chihaya Kimura, Yuma Nihashi, Koji Umezawa, Takeshi Shimosato, Tomohide Takaya   +5 more
doaj   +2 more sources

Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus [PDF]

Frontiers in Immunology, 2020
Current influenza vaccines are generally effective against highly similar (homologous) strains, but their effectiveness decreases markedly against antigenically mismatched (heterologous) strains. One way of developing a universal influenza vaccine with a
Seiki Shirai, Seiki Shirai, Meito Shibuya, Meito Shibuya, Atsushi Kawai, Atsushi Kawai, Shigeyuki Tamiya, Shigeyuki Tamiya, Lisa Munakata, Daiki Omata, Ryo Suzuki, Taiki Aoshi, Taiki Aoshi, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +16 more
doaj   +2 more sources

Neonate intestinal immune response to CpG oligodeoxynucleotide stimulation. [PDF]

PLoS ONE, 2009
BACKGROUND: The development of mucosal vaccines is crucial to efficiently control infectious agents for which mucosae are the primary site of entry. Major drawbacks of these protective strategies are the lack of effective mucosal adjuvant.
Sonia Lacroix-Lamandé, Nicolas Rochereau, Roselyne Mancassola, Mathieu Barrier, Amandine Clauzon, Fabrice Laurent   +5 more
doaj   +9 more sources

Evaluating the immune responses stimulated by CpG oligodeoxynucleotides [PDF]

Nucleic Acids Symposium Series, 2003
CpG oligonucleotides have recently been highlighted as an immunomodulator that biases toward a Th1-dominant phenotype. To substantiate the synergism between CpG-ODNs and Ag, we introduced a linked conjugate between CpG-ODNs and Ag and the antiviral effect of antigen-conjugated CpG-ODNs therapy following an infection of mice with the influenza virus A ...
Ryouji Ueki, Mayuka Yano, Gunther Hartmann, Makoto Kuwahara, Mieko Hayashi, Takayuki Abe, Naoko Miyao-Kurosaki, Miwa Ogata, Masayuki Fujii, Hiroshi Takaku   +9 more
openaire   +4 more sources

Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice [PDF]

Biological Research, 2016
BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer.
Xuan Li, Guoxiong Xu, Tiankui Qiao, Sujuan Yuan, Xibing Zhuang   +4 more
doaj   +2 more sources

A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice [PDF]

Virology Journal, 2018
Background Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity
Pengcheng Yu, Jianghong Yan, Weicheng Wu, Xiaoyan Tao, Xuexin Lu, Shuqing Liu, Wuyang Zhu   +6 more
doaj   +2 more sources

Role of immunostimulatory deoxycytidylate-phosphate-deoxyguanylate (CpG) motifs in oral bacteria associated with oral diseases [PDF]

Journal of Oral Microbiology
Background CpG oligodeoxynucleotide motifs in bacterial DNA with composition variations exhibit potent immunostimulation. The effect of different compositions in oral infections is unclear. This study aims to investigate CpG motifs in bacteria associated
Pisit Charoenwongwatthana, Oslovenya S. Caroline, Halah Ahmed, Jamie Coulter, Chien-Yi Chang   +4 more
doaj   +2 more sources

Synergy effects of Polyinosinic-polycytidylic acid, CpG oligodeoxynucleotide, and cationic peptides to adjuvant HPV E7 epitope vaccine through preventive and therapeutic immunization in a TC-1 grafted mouse model [PDF]

Human Vaccines & Immunotherapeutics, 2018
Cross-talk by pattern recognition receptors may facilitate the maturation of dendritic cells and fine tune the immune response. Thus, the inclusion of ligands agonistic to multiple receptors in a vaccine formula may be an effective strategy to elicit ...
Cunbao Liu, Xiaojie Chu, Pengyan Sun, Xuejun Feng, Weiwei Huang, Hongxian Liu, Yanbing Ma   +6 more
doaj   +2 more sources

CpG-Oligodeoxynucleotide Treatment Protects against Ionizing Radiation-Induced Intestine Injury. [PDF]

PLoS ONE, 2013
the bone marrow and the intestine are the major sites of ionizing radiation (IR)-induced injury. Our previous study demonstrated that CpG-oligodeoxynucleotide (ODN) treatment mitigated IR-induced bone marrow injury, but its effect on the intestine is not
Chao Zhang, Jin Ni, Bai-Long Li, Fu Gao, Hu Liu, Wen Liu, Yi-Juan Huang, Jian-Ming Cai   +7 more
doaj   +2 more sources

CpG oligodeoxynucleotide ligand potentiates the activity of the pVAX1-Sj26GST. [PDF]

Biomed Rep, 2013
Schistosomiasis is considered one of the most important neglected tropical diseases and remains a major public health problem in endemic countries. Toll-like receptor (TLR) ligands have been investigated as potential vaccine adjuvants for tumor and virus immunotherapy. However, few TLR ligands affecting schistosoma vaccines have been characterized.
Lu J, Jiang S, Ye S, Deng Y, Ma S, Li CP.   +5 more
europepmc   +5 more sources