Results 91 to 100 of about 9,596 (243)

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, Volume 12, Issue 47, December 18, 2025.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Effects of KLK Peptide on Adjuvanticity of Different ODN Sequences

Vaccines, 2016
Endosomal Toll-like receptors (TLR) such as TLR3, 7, 8 and 9 recognize pathogen associated nucleic acids. While DNA sequence does influence degree of binding to and activation of TLR9, it also appears to influence the ability of the ligand to reach the ...
Ghania Chikh, Rachel Luu, Shobhna Patel, Heather L. Davis, Risini D. Weeratna   +4 more
doaj   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

CpG-ODN-induced sustained expression of BTLA mediating selective inhibition of human B cells. [PDF]

, 2013
BTLA (B- and T-lymphocyte attenuator) is a prominent co-receptor that is structurally and functionally related to CTLA-4 and PD-1. In T cells, BTLA inhibits TCR-mediated activation.
Derré, L., Gertner-Dardenne, J., Mamessier, E., Olive, D., Pastor, S., Rivals, J.P., Speiser, D.E., Thibult, M.L.   +7 more
core   +3 more sources

Ferumoxytol and CpG oligodeoxynucleotide 2395 synergistically enhance antitumor activity of macrophages against NSCLC with EGFRL858R/T790M mutation

International Journal of Nanomedicine, 2019
Guoqun Wang,1 Jiaojiao Zhao,2 Meiling Zhang,1 Qian Wang,1 Bo Chen,3 Yayi Hou,2,4 Kaihua Lu11Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; 2The State Key Laboratory ...
Wang G, Zhao J, Zhang M, Wang Q, Chen B, Hou Y, Lu K   +6 more
doaj  

Advancing Tuberculosis Chemotherapy: Targeted Nanomedicines for the Mycobacterium TB Granuloma

Small, Volume 21, Issue 49, December 10, 2025.
This graphical abstract illustrates nanosystems used for targeted drug delivery into tuberculosis granulomas. It shows how targeting is influenced by size, pH, redox sensitivity, and surface charge. Various nanoparticles are incorporated with drugs to enhance penetration, stability, and release.
Shreya Ranjith Singh, Maya Mellisa Makatini, Thashree Marimuthu, Yahya Essop Choonara   +3 more
wiley   +1 more source

Phase 1 Trial of Vaccination with Autologous Tumor Cells and Antisense Directed Against the Insulin Growth Factor Type 1 Receptor (IGF-1R AS ODN) in Patients with Recurrent Glioblastoma [PDF]

, 2018
Background: Extending a previous Phase I study, we report the results of a second Phase I autologous tumor cell vaccination trial for patients with recurrent glioblastomas (IND 14379-101, NCT01550523). Methods: Following surgery, subjects were treated by
Andrews MD, David W., Harshyne, PhD, Larry, Hooper, PhD, D. Craig, Judy, MD, Kevin   +3 more
core   +2 more sources

TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

Frontiers in Immunology, 2011
Plasma cells have a heterogeneous phenotype in humans. While bone marrow plasma cells are CD20-CD138+, tonsil plasma cells are CD20+CD138+/- and peripheral plasmablasts are CD20-CD138-.
Alexandrine eGeffroy-Luseau, Alexandrine eGeffroy-Luseau, David eChiron, David eChiron, Géraldine eDescamps, Géraldine eDescamps, Gaëtan eJégo, Gaëtan eJégo, Martine eAmiot, Martine eAmiot, Catherine ePellat-Deceunynck, Catherine ePellat-Deceunynck   +11 more
doaj   +1 more source

Metal–Organic Frameworks Against Tumor Metastasis: Therapeutic Targets, Strategies, and Challenges for Clinical Translation

Cancer Medicine, Volume 14, Issue 22, November 2025.
ABSTRACT Tumor invasion and metastasis are the primary causes of cancer‐related mortality and have a profound impact on patient prognosis. This review comprehensively examines the application of Metal‐Organic Frameworks (MOFs) in anti‐metastatic therapy and establishes a theoretical foundation for their clinical translation.
Jiahui Wang, Xiuxiu Qiu, Ruoyu Wang, Beibei Hong, Hegen Li, Zhanxia Zhang   +5 more
wiley   +1 more source

Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes. [PDF]

, 2011
Immune protection from infectious diseases and cancer is mediated by individual T cells of different clonal origin. Their functions are tightly regulated but not yet fully characterized.
Appay, B. Gupta, Barbey, Boon, D. E. Speiser, Derre, E. M. Iancu, Iancu, Khan, L. Baitsch, Messaoudi, N. Rufer, O. Michielin, P. Baumgaertner, P. Romero, Romero, Romero, Rufer, S. Wieckowski, Sallusto, Speiser, Touvrey, Valmori   +22 more
core   +2 more sources