Results 11 to 20 of about 5,254 (231)

TLR9 ligand (CpG oligodeoxynucleotide) induces CLL B-cells to differentiate into CD20+ antibody-secreting cells [PDF]

Frontiers in Immunology, 2014
B-cell chronic lymphocytic leukemia (CLL) is the most frequent adult leukemia in the Western world. It is a heterogeneous disease characterized by clonal proliferation and the accumulation of CD5+ mature B lymphocytes.
Hussein eGhamlouch, Hussein eGhamlouch, Hakim eOuled-Haddou, Aude eGuyart, Aline eRegnier, Aline eRegnier, Stéphanie eTrudel, Stéphanie eTrudel, Jean-Francois eClaisse, Vincent eFuentes, Bruno eRoyer, Bruno eRoyer, Jean-Pierre eMarolleau, Jean-Pierre eMarolleau, Brigitte eGubler, Brigitte eGubler   +15 more
doaj   +2 more sources

Augmented immunogenicity of the HPV16 DNA vaccine via dual adjuvant approach: integration of CpG ODN into plasmid backbone and co-administration with IL-28B gene adjuvant [PDF]

Virology Journal
Therapeutic human papillomavirus (HPV) DNA vaccine is an attractive option to control existed HPV infection and related lesions. The two early viral oncoproteins, E6 and E7, are continuously expressed in most HPV-related pre- and cancerous cells, and are
Yan Zhou, Ting Zhang, Zhirong Wang, Xuemei Xu   +3 more
doaj   +2 more sources

CpG oligodeoxynucleotides as immunotherapy in cancer [PDF]

Update on Cancer Therapeutics, 2008
Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects and can enhance the anti-cancer activity of a variety of cancer treatments. Synergy between CpG ODN and monoclonal antibodies has been noted in various preclinical models. Early clinical
George J. Weiner, Bernd Jahrsdörfer
openaire   +3 more sources

CpG oligodeoxynucleotides as mucosal adjuvants [PDF]

Human Vaccines & Immunotherapeutics, 2015
Bacterial DNA comprising palindromic sequences and containing unmethylated CpG is recognized by toll-like receptor 9 of plasmacytoid dendritic cells (pDCs) and induces the production of interferon-α and chemokines, leading to the activation of a Th1 immune response. Therefore, synthetic equivalents of bacterial DNA (CpG oligodeoxynucleotides) have been
Sumiko Iho, Fumiko Suzuki, Jun-ichi Maeyama   +2 more
openaire   +3 more sources

Gold nanoparticle delivery of modified CpG stimulates macrophages and inhibits tumor growth for enhanced immunotherapy. [PDF]

PLoS ONE, 2013
Gold nanoparticle accumulation in immune cells has commonly been viewed as a side effect for cancer therapeutic delivery; however, this phenomenon can be utilized for developing gold nanoparticle mediated immunotherapy. Here, we conjugated a modified CpG
Adam Yuh Lin, Joao Paulo Mattos Almeida, Adham Bear, Nathan Liu, Laureen Luo, Aaron Edward Foster, Rebekah Anna Drezek   +6 more
doaj   +1 more source

Immunopharmacology of CpG Oligodeoxynucleotides and Ribavirin [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACT To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells.
Arthur M. Krieg, Hanna Hartmann, Andrea Janosch, Marion Jurk, Christian Schetter, Robert Rankin, Tanja Wader, Jörg Vollmer, Ulrike Samulowitz   +8 more
openaire   +2 more sources

Flt3L, LIF, and IL‐10 combination promotes the selective in vitro development of ESAMlow cDC2B from murine bone marrow

European Journal of Immunology, Volume 52, Issue 12, Page 1946-1960, December 2022., 2022
In vitro culture of murine bone marrow cells in Flt3L + LIF + IL‐10 promotes CD11b+ ESAMlow cDC2B subset generation from CDP but blocks cDC1 and pDC development. Flt3L alone or combined does not induce cDC2A generation in vitro. Abstract The development of two conventional dendritic cells (DC) subsets (cDC1 and cDC2) and the plasmacytoid DC (pDC) in ...
Laura Cyran, Julia Serfling, Luisa Kirschner, Hartmann Raifer, Michael Lohoff, Heike M. Hermanns, Andreas Kerstan, Jochen Bodem, Manfred B. Lutz   +8 more
wiley   +1 more source

TLR 9 activation in dendritic cells enhances salmonella killing and antigen presentation via involvement of the reactive oxygen species. [PDF]

PLoS ONE, 2010
Synthetic CpG containing oligodeoxynucleotide Toll like receptor-9 agonist (CpG DNA) activates innate immunity and can stimulate antigen presentation against numerous intracellular pathogens.
Amit Lahiri, Ayan Lahiri, Priyanka Das, Janakiraman Vani, M S Shaila, Dipshikha Chakravortty   +5 more
doaj   +1 more source

TLR9/NF-kB Pathway Regulates Brucella CpG DNA-mediated Cytokine Response in Human Peripheral Blood Mononuclear Cells [PDF]

Iranian Journal of Immunology, 2021
Background: It was reported that targeting the Toll-like receptor9(TLR9) signaling pathway can be a promising therapeuticstrategy forinterventions in various inflammatory and infectiousdiseases.
Yunzhi Peng, Wenhui Bai, Zhanli Wang, Hui Yu   +3 more
doaj   +1 more source

Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation

Brain Pathology, Volume 33, Issue 1, January 2023., 2023
Schematic depicting mechanism by which HPC protects neurons against tGCI in CA1 through Piwil2‐mediated epigenetics. Abstract Epigenetic modification contributes to the pathogenesis of cerebral ischemia. Piwil2 belongs to the PIWI proteins subfamily and has a key role in the regulation of gene transcription through epigenetics.
Lixuan Zhan, Meiyan Chen, Taoyan Pang, Xinyu Li, Long Long, Donghai Liang, Linhui Peng, Weiwen Sun, En Xu   +8 more
wiley   +1 more source