Results 211 to 220 of about 9,596 (243)

CpG oligodeoxynucleotides in asthma.

Current opinion in investigational drugs (London, England : 2000), 2002
Asthma is a major health problem, of which the prevalence and severity are increasing, particularly in industrialized nations. One hypothesis for this is that diminished exposure to childhood infections in modern society has led to decreased Th1-type inflammation.
I, Hussain, J N, Kline
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Silk Fibroin for CpG Oligodeoxynucleotide Delivery

ACS Biomaterials Science & Engineering, 2019
CpG oligodeoxynucleotides (ODNs) have attracted increasing attention as immunotherapeutic agents. However, efficient transfection of CpG ODNs into the immune cells remains a big challenge. In this study, for the first time, we reported that silk fibroin (SF) could function as an efficient carrier for CpG ODNs.
Huijie Zhang, Li Lai, Yalin Wang, Baoting Ye, Shuhao Deng, Airan Ding, Liping Teng, Lipeng Qiu, Jinghua Chen   +8 more
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Safety of CpG Oligodeoxynucleotides in Veterinary Species

Antisense and Nucleic Acid Drug Development, 2003
Bacterial DNA and synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs in particular sequence contexts (CpG ODN) are recognized as a danger signal by the innate immune system of vertebrates. For this reason, CpG ODNs have a potential application as both an adjuvant and nonspecific immune modulator and are currently being evaluated ...
X P, Ioannou, P, Griebel, A, Mena, S M, Gomis, D L, Godson, G, Mutwiri, R, Hecker, L A, Babiuk, S, van Drunen Littel-van den Hurk   +8 more
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Immunotherapeutic uses of CpG oligodeoxynucleotides

Nature Reviews Immunology, 2004
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger an immunomodulatory cascade that involves B and T cells, natural killer cells and professional antigen-presenting cells. The response to CpG ODNs skews the host's immune milieu in favour of T helper 1 (TH1)-cell responses and pro-inflammatory cytokine production ...
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CpG Oligodeoxynucleotide Enhances Tumor Response to Radiation

Cancer Research, 2004
Abstract CpG oligodeoxynucleotides (ODNs) are synthetic DNA sequences containing unmethylated cytosine-guanine motifs with potent immunomodulatory effects. Via Toll-like receptor 9 agonism of dendritic cells and B cells, CpG ODNs induce cytokines, activate natural killer cells, and elicit vigorous T-cell responses that lead to ...
Luka, Milas, Kathryn A, Mason, Hisanori, Ariga, Nancy, Hunter, Robert, Neal, David, Valdecanas, Arthur M, Krieg, John K, Whisnant   +7 more
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Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists

Advanced Drug Delivery Reviews, 2009
Toll-like receptor 9 (TLR9) agonists have demonstrated substantial potential as vaccine adjuvants, and as mono- or combination therapies for the treatment of cancer and infectious and allergic diseases. Commonly referred to as CpG oligodeoxynucleotides (ODN), TLR9 agonists directly induce the activation and maturation of plasmacytoid dendritic cells ...
Jörg, Vollmer, Arthur M, Krieg
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Therapeutic Applications of CpG-Containing Oligodeoxynucleotides

Antisense and Nucleic Acid Drug Development, 1998
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines.
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Immunostimulatory CpG-Oligodeoxynucleotides Cause Extramedullary Murine Hemopoiesis

The Journal of Immunology, 1999
AbstractBacterial DNA and the synthetic CpG-oligodeoxynucleotides (ODNs) derived thereof have attracted attention because they activate cells of the adaptive immune system (lymphocytes) and the innate immune system (APCs) in a sequence-dependent manner. Here, we addressed whether CpG-ODNs affect hemopoiesis.
T, Sparwasser, L, Hültner, E S, Koch, A, Luz, G B, Lipford, H, Wagner   +5 more
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Use of CpG oligodeoxynucleotides as immune adjuvants

Immunological Reviews, 2004
Summary:  Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of T helper 1 (Th1) and pro‐inflammatory cytokines and the maturation/activation of professional antigen‐presenting cells.
Dennis M, Klinman, Debra, Currie, Ihsan, Gursel, Daniela, Verthelyi   +3 more
openaire   +2 more sources