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Immunotherapy of asthma using CpG oligodeoxynucleotides
Immunologic Research, 2007Asthma and other atopic disorders have increased in prevalence and severity over the past three decades. Reduced risk of atopic disease associated with early life exposure to infections and microbes has raised the possibility that pathogen-associated molecular patterns (PAMPs) may confer protection against allergic disorders, a concept that has been ...
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Role of CpG oligodeoxynucleotide in angiogenesis
The Lancet, 2016Abstract Background Angiogenesis involves multiple cell types, including close association with immune cells and vascular growth factors. We have previously shown that the toll-like receptor 9 (TLR9) agonist CpG oligodeoxynucleotide (ODN) inhibits corneal angiogenesis.
Lei Liu +3 more
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CpG Oligodeoxynucleotides as TLR9 Agonists
BioDrugs, 2010Unmethylated cytosine-phosphate-guanine (CpG) dinucleotides in microbial DNA sequences activate Toll-like receptor (TLR) 9, and previous studies have shown that oligodeoxynucleotides (ODNs) containing CpG in specific base sequence motifs (CpG ODNs) can reiterate the majority of the immunomodulatory effects produced by bacterial DNA.
Gaurav K, Gupta, Devendra K, Agrawal
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Immunostimulatory CpG oligodeoxynucleotides and antibody therapy of cancer
Seminars in Oncology, 2003Synthetic oligodeoxynucleotides containing CG motifs (CpG ODN) have potent immunostimulatory properties, and have potential as immunotherapeutic agents in cancer. Animal models suggest CpG ODN can activate a variety of immune effector cells such as natural killer (NK) cells, and also enhance the efficacy of tumor immunization when used as immune ...
Bernd, Jahrsdörfer, George J, Weiner
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CpG oligodeoxynucleotide-based therapy of lymphoid malignancies
Advanced Drug Delivery Reviews, 2009Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects. CpG ODN are being explored as immune adjuvants in vaccination strategies and as potential treatments for a wide variety of disorders including cancer and asthma.
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CpG oligodeoxynucleotides activate grass carp (Ctenopharyngodon idellus) macrophages
Developmental & Comparative Immunology, 2003In mice and humans, B cells, antigen-presenting cells including monocytes, macrophages and dendritic cells and natural killer cells can be stimulated directly or indirectly by the bacterial DNA and oligodeoxynucleotides (ODN) containing the CpG motifs (CpG DNA). Using head kidney macrophages of grass carp (Ctenopharyngodon idellus) as an in vitro model,
Zhen, Meng +2 more
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CpG-oligodeoxynucleotides enhance porcine immunity to Toxoplasma gondii
Veterinary Parasitology, 2004Protection against a challenge infection with Toxoplasma gondii VEG strain oocysts was examined in pigs after vaccination with T. gondii RH strain tachyzoites with or without a porcine specific synthetic oligodeoxynucleotides (ODN) containing immunostimulatory CpG motifs.
Kringel, Helene +4 more
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Immunological Efficacy and Safety of Synthesized CpG Oligodeoxynucleotides
Applied Biochemistry and Microbiology, 2018The technology for synthesis is described, and the adjuvant properties of CpG oligodeoxynucleotides (CpG-ODNs) are assessed. CpG-ODN sequences were generated according to the available sequences on an automatic synthesizer. The adjuvant activity was evaluated with CpG-ODNs in combination with a recombinant protective antigen and EA1, an S-layer protein
O.M. Kudriavtseva +6 more
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Immunotherapeutic potential of CpG oligodeoxynucleotides in veterinary species
Immunopharmacology and Immunotoxicology, 2013Innate immunity plays a critical role in host defense against infectious diseases by discriminating between self and infectious non-self. The recognition of infectious non-self involves germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Anju, Manuja +4 more
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Immune Mechanisms and Therapeutic Potential of CpG Oligodeoxynucleotides
International Reviews of Immunology, 2006Unmethylated CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides activate immune cells that express Toll-like Receptor 9. Activation through this receptor triggers cellular signaling that leads to production of a proinflammatory and a Th1-type, antigen-specific immune response.
Heather L, Wilson +5 more
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