Results 231 to 240 of about 9,596 (243)

Use of CpG oligodeoxynucleotides as immunoprotective agents

Expert Opinion on Biological Therapy, 2004
Single-stranded oligodeoxynucleotides (ODNs) synthesised to express unmethylated 'CpG motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs stimulate cells that express Toll-like receptor 9, initiating an immunomodulatory cascade resulting in the activation of B and T lymphocytes, natural killer cells, monocytes ...
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Modulation of Murine Allergic Rhinosinusitis by CpG Oligodeoxynucleotides

The Laryngoscope, 2002
AbstractBackground Allergic rhinosinusitis is characterized by eosinophilic inflammation of the upper airway, which is induced by TH‐2 cytokines. CpG oligodeoxynucleotides (ODN) are known to induce TH‐1 and to suppress TH‐2 cytokines in a variety of settings, including murine models of asthma.Objective To examine the effect of CpG ODN in a murine model
Iftikhar, Hussain, Vipul V, Jain, Kunihiko, Kitagaki, Thomas R, Businga, Patrick, O'Shaughnessy, Joel N, Kline   +5 more
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Lack of Immune Stimulation by Immobilized CpG-Oligodeoxynucleotide

Antisense and Nucleic Acid Drug Development, 1999
Selected phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses, including B-cell proliferation and cytokine production. The mechanism by which cells detect CpG-motifs is not known. There are conflicting reports in the literature concerning the ability of CpG-ODN linked to solid supports to stimulate immunity.
L, Manzel, D E, Macfarlane
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Activation of microglia and astrocytes by CpG oligodeoxynucleotides

Neuroreport, 2001
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate cells of the immune system to secrete a variety of cytokines and chemokines. This function can be carried out by microglia and astrocytes in the CNS.
S, Takeshita, F, Takeshita, D E, Haddad, N, Janabi, D M, Klinman   +4 more
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Modulation of NK cell activity by CpG oligodeoxynucleotides

Immunologic Research, 2007
Oligodeoxynucleotides (ODN) with hypomethylated CpG motifs have been found to be potent stimulators of various aspects of innate and adaptive immunity. One of their major effects is the activation of natural killer (NK) killing activity in vitro and in vivo.
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Immunotherapeutic applications of CpG-containing oligodeoxynucleotides.

Drug news & perspectives, 2003
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines.
D M, Klinman, K J, Ishii, M, Gursel, I, Gursel, S, Takeshita, F, Takeshita   +5 more
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Immunotherapeutic Approach with Oligodeoxynucleotides Containing CpG Motifs (CpG-ODN) in Malignant Glioma

2012
Bacterial DNA and synthetic oligodeoxynucleotides containing CpG motifs (CpG-ODNs) are strong activators of both innate and specific immunity, driving the immune response towards the Th1 phenotype. In cancer patients, CpG-ODNs can be used to activate the innate immunity and trigger a tumor-specific immune response.
Renata, Ursu, Antoine F, Carpentier
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Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999
Immune stimulation has been widely recognized as an undesirable side effect of certain antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic application. It is now clear that these dose-dependent immune stimulatory effects primarily result from the presence of an unmethylated CpG dinucleotide in particular base contexts ('CpG
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CpG Oligodeoxynucleotides

2001
Joel N. Kline, Arthur M. Krieg
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Adjuvanicity of CpG oligodeoxynucleotides in grouper

Fish & Shellfish Immunology, 2013
H.C. Chuang, T.L. Ji, F.Y. Lee, S.P. Chen, N.Y. Chen, P.P. Chiou   +5 more
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