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Plasmacytoid Dendritic Cells: Bring a Glimmer of Hope for Patients with Lymphangioleiomyomatosis. [PDF]
Am J Respir Cell Mol BiolDu H, Liu HJ.
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Advances of signal transducer and activator of transcription 3 inhibitors in acute myeloid leukemia (Review). [PDF]
Oncol LettCheng H, Chen L, Huang C.
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Silk Fibroin for CpG Oligodeoxynucleotide Delivery.
ACS Biomaterials Science & Engineering, 2019CpG oligodeoxynucleotides (ODNs) have attracted increasing attention as immunotherapeutic agents. However, efficient transfection of CpG ODNs into the immune cells remains a big challenge. In this study, for the first time, we reported that silk fibroin (
Huijie Zhang +8 more
semanticscholar +4 more sources
Development of CpG oligodeoxynucleotide TLR9 agonists in anti-cancer therapy
Expert Review of Anticancer Therapy, 2021Introduction Toll-like receptor-9(TLR9) can recognize the foreign unmethylated CpG DNA, and thus intrigue a strong Th1 response which plays a crucial role in the innate and adaptive immune responses.
Yizhen Jin +3 more
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Immunotherapeutic applications of CpG oligodeoxynucleotide TLR9 agonists.
Advanced Drug Delivery Reviews, 2009Toll-like receptor 9 (TLR9) agonists have demonstrated substantial potential as vaccine adjuvants, and as mono- or combination therapies for the treatment of cancer and infectious and allergic diseases. Commonly referred to as CpG oligodeoxynucleotides (ODN), TLR9 agonists directly induce the activation and maturation of plasmacytoid dendritic cells ...
J. Vollmer, A. Krieg
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The Potential of CpG Oligodeoxynucleotides as Mucosal Adjuvants
Critical Reviews™ in Immunology, 2001The development of mucosal vaccines for humans has been hindered by the lack of safe yet effective mucosal adjuvants. Bacterial toxins are commonly used as adjuvants in animal models, but they are too toxic for use in humans. A novel class of adjuvant is CpG DNA, which contains unmethylated CpG dinucleotides in particular base contexts (CpG motifs ...
M J McCluskie +3 more
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ACS Biomaterials Science & Engineering, 2018
CpG oligodeoxynucleotides (CpG ODNs) bind to toll-like receptor 9 (TLR9) and activate the immune system. Thus, CpG ODNs have attracted considerable interest as immunotherapeutic agents or adjuvants for many diseases.
Ting Cheng +3 more
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CpG oligodeoxynucleotides (CpG ODNs) bind to toll-like receptor 9 (TLR9) and activate the immune system. Thus, CpG ODNs have attracted considerable interest as immunotherapeutic agents or adjuvants for many diseases.
Ting Cheng +3 more
semanticscholar +1 more source
Role of CpG oligodeoxynucleotide in angiogenesis
The Lancet, 2016Abstract Background Angiogenesis involves multiple cell types, including close association with immune cells and vascular growth factors. We have previously shown that the toll-like receptor 9 (TLR9) agonist CpG oligodeoxynucleotide (ODN) inhibits corneal angiogenesis.
Lei Liu +3 more
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CpG Oligodeoxynucleotides in Asthma
2002Asthma is a major health problem, of which the prevalence and severity are increasing, particularly in industrialized nations. One hypothesis for this is that diminished exposure to childhood infections in modern society has led to decreased Th1-type inflammation.
Iftikhar Hussain, Joel N. Kline
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Safety of CpG Oligodeoxynucleotides in Veterinary Species
Antisense and Nucleic Acid Drug Development, 2003Bacterial DNA and synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs in particular sequence contexts (CpG ODN) are recognized as a danger signal by the innate immune system of vertebrates. For this reason, CpG ODNs have a potential application as both an adjuvant and nonspecific immune modulator and are currently being evaluated ...
P. Griebel +8 more
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