Results 261 to 270 of about 79,604 (302)

BN nanospheres functionalized with mesoporous silica for enhancing CpG oligodeoxynucleotide-mediated cancer immunotherapy.

Nanoscale, 2018
CpG oligodeoxynucleotides (CpG ODNs) possess strong immunostimulatory activity, which hold great promise in cancer immunotherapy. However, their therapeutic efficacy is largely limited due to nuclease degradation and poor cellular internalization ...
Huijie Zhang, Ting Cheng, Li Lai, Shuhao Deng, Ruixi Yu, Lipeng Qiu, Juan Zhou, Guozhong Lu, C. Zhi, Jinghua Chen   +9 more
semanticscholar   +1 more source

Activation of microglia and astrocytes by CpG oligodeoxynucleotides

Neuroreport, 2001
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs stimulate cells of the immune system to secrete a variety of cytokines and chemokines. This function can be carried out by microglia and astrocytes in the CNS.
Diana E. Haddad, Fumihiko Takeshita, Dennis M. Klinman, Saoko Takeshita, Nazila Janabi   +4 more
openaire   +3 more sources

Use of CpG oligodeoxynucleotides as immune adjuvants

Immunological Reviews, 2004
Summary:  Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of T helper 1 (Th1) and pro‐inflammatory cytokines and the maturation/activation of professional antigen‐presenting cells.
Daniela Verthelyi, Ihsan Gursel, Dennis M. Klinman, Debra Currie   +3 more
openaire   +3 more sources

Immunostimulatory CpG oligodeoxynucleotides and antibody therapy of cancer

Seminars in Oncology, 2003
Synthetic oligodeoxynucleotides containing CG motifs (CpG ODN) have potent immunostimulatory properties, and have potential as immunotherapeutic agents in cancer. Animal models suggest CpG ODN can activate a variety of immune effector cells such as natural killer (NK) cells, and also enhance the efficacy of tumor immunization when used as immune ...
Bernd Jahrsdörfer, George J. Weiner
openaire   +3 more sources

Strategies for enhancing the immunostimulatory effects of CpG oligodeoxynucleotides

Journal of Controlled Release, 2004
Synthetic oligodeoxynucleotides (ODN) containing CpG sequences are recognized as a "danger" signal by the immune system of mammals. As a consequence, CpG ODN stimulate innate and adaptive immune responses in humans and a variety of animal species. Indeed, the potential of CpG ODN as therapeutic agents and vaccine adjuvants has been demonstrated in ...
Lorne A. Babiuk, George Mutwiri, Shawn Babiuk, A. K. Nichani   +3 more
openaire   +2 more sources

Immunotherapeutic uses of CpG oligodeoxynucleotides

Nature Reviews Immunology, 2004
Synthetic oligodeoxynucleotides (ODNs) that contain immunostimulatory CpG motifs trigger an immunomodulatory cascade that involves B and T cells, natural killer cells and professional antigen-presenting cells. The response to CpG ODNs skews the host's immune milieu in favour of T helper 1 (TH1)-cell responses and pro-inflammatory cytokine production ...
openaire   +3 more sources

Heterogeneity in the Human Response to Immunostimulatory CpG Oligodeoxynucleotides

Journal of Immunotherapy, 2003
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs trigger an immune response characterized by proliferation, B-cell activation, and cytokine production. CpG ODNs show promise in animal models as vaccine adjuvants and anti-allergens and for the treatment of infectious diseases and cancer.
Dennis M. Klinman, Cynthia A. Leifer, Daniela Verthelyi   +2 more
openaire   +3 more sources

Therapeutic Applications of CpG-Containing Oligodeoxynucleotides

Antisense and Nucleic Acid Drug Development, 1998
Bacterial DNA and synthetic oligodeoxynucleotides (ODN) expressing unmethylated CpG motifs stimulate the mammalian immune system to mount a rapid innate immune response. This response is characterized by the production of polyreactive IgM, immunomodulatory cytokines and chemokines.
openaire   +3 more sources

Modulation of Murine Allergic Rhinosinusitis by CpG Oligodeoxynucleotides

The Laryngoscope, 2002
AbstractBackground Allergic rhinosinusitis is characterized by eosinophilic inflammation of the upper airway, which is induced by TH‐2 cytokines. CpG oligodeoxynucleotides (ODN) are known to induce TH‐1 and to suppress TH‐2 cytokines in a variety of settings, including murine models of asthma.Objective To examine the effect of CpG ODN in a murine model
Kunihiko Kitagaki, Vipul V. Jain, Joel N. Kline, Patrick T. O'Shaughnessy, Thomas R. Businga, Iftikhar Hussain   +5 more
openaire   +3 more sources

Immunotherapy of asthma using CpG oligodeoxynucleotides

Immunologic Research, 2007
Asthma and other atopic disorders have increased in prevalence and severity over the past three decades. Reduced risk of atopic disease associated with early life exposure to infections and microbes has raised the possibility that pathogen-associated molecular patterns (PAMPs) may confer protection against allergic disorders, a concept that has been ...
openaire   +3 more sources