Results 271 to 280 of about 79,604 (302)

Immunotherapeutic potential of CpG oligodeoxynucleotides in veterinary species

Immunopharmacology and Immunotoxicology, 2013
Innate immunity plays a critical role in host defense against infectious diseases by discriminating between self and infectious non-self. The recognition of infectious non-self involves germ-line encoded pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs).
Balvinder K. Manuja, Raj Kumar Singh, Jyoti Kaushik, Harisankar Singha, Anju Manuja   +4 more
openaire   +2 more sources

Microfluidic generation of chitosan/CpG oligodeoxynucleotide nanoparticles with enhanced cellular uptake and immunostimulatory properties.

Lab on a Chip, 2014
Chitosan/cytosine-phosphodiester-guanine oligodeoxynucleotide (CpG ODN) nanoparticles as potential immunostimulatory adjuvants were synthesized by the conventional bulk mixing (BM) method and a novel microfluidic (MF) method.
Song Chen, Huijie Zhang, Xuetao Shi, Hongkai Wu, N. Hanagata   +4 more
semanticscholar   +1 more source

Immune Mechanisms and Therapeutic Potential of CpG Oligodeoxynucleotides

International Reviews of Immunology, 2006
Unmethylated CpG motifs in bacterial DNA and synthetic oligodeoxynucleotides activate immune cells that express Toll-like Receptor 9. Activation through this receptor triggers cellular signaling that leads to production of a proinflammatory and a Th1-type, antigen-specific immune response.
Heather L. Wilson, A. Marianela Lopez, Lorne A. Babiuk, Arshud Dar, Scott Napper, George Mutwiri   +5 more
openaire   +3 more sources

CpG Oligodeoxynucleotide Enhances Tumor Response to Radiation

Cancer Research, 2004
Abstract CpG oligodeoxynucleotides (ODNs) are synthetic DNA sequences containing unmethylated cytosine-guanine motifs with potent immunomodulatory effects. Via Toll-like receptor 9 agonism of dendritic cells and B cells, CpG ODNs induce cytokines, activate natural killer cells, and elicit vigorous T-cell responses that lead to ...
Robert Neal, David Valdecanas, Hisanori Ariga, John K. Whisnant, Arthur M. Krieg, Luka Milas, Nancy Hunter, Kathryn A. Mason   +7 more
openaire   +2 more sources

Use of CpG oligodeoxynucleotides as immunoprotective agents

Expert Opinion on Biological Therapy, 2004
Single-stranded oligodeoxynucleotides (ODNs) synthesised to express unmethylated 'CpG motifs' mimic the ability of bacterial DNA to trigger the innate immune system. CpG ODNs stimulate cells that express Toll-like receptor 9, initiating an immunomodulatory cascade resulting in the activation of B and T lymphocytes, natural killer cells, monocytes ...
openaire   +3 more sources

Modulation of NK cell activity by CpG oligodeoxynucleotides

Immunologic Research, 2007
Oligodeoxynucleotides (ODN) with hypomethylated CpG motifs have been found to be potent stimulators of various aspects of innate and adaptive immunity. One of their major effects is the activation of natural killer (NK) killing activity in vitro and in vivo.
openaire   +3 more sources

Effects of CpG- oligodeoxynucleotides on dendritic cell development

Nucleic Acids Symposium Series, 2008
Dendritic cell (DC) development begins in the bone marrow and immature progenitors reach their sites of residence in lymphoid organs. The mechanism of DC development in the bone marrow and in peripheral lymphoid organs is poorly understood. Here, we examined the effects of synthetic oligodeoxynucleotides containing a CpG motif (CpG-ODNs) on the ...
Fumito Tani, Naofumi Kitabatake, Ryuji Ohue   +2 more
openaire   +3 more sources

B cells contribute to the antitumor activity of CpG-oligodeoxynucleotide in a mouse model of metastatic lung carcinoma.

American Journal of Respiratory and Critical Care Medicine, 2011
RATIONALE CpG-oligodeoxynucleotide (CpG-ODN; CpG), a Toll-like receptor-9 ligand, has been widely studied as a potential antitumor adjuvant. Toll-like receptor-9 is highly expressed on lung carcinoma tissues and some immune cells, such as plasmacytoid ...
R. Sorrentino, S. Morello, Giovanni Forte, A. Montinaro, Genoveffa De Vita, A. Luciano, G. Palma, C. Arra, P. Maiolino, I. Adcock, A. Pinto   +10 more
semanticscholar   +1 more source

Lack of Immune Stimulation by Immobilized CpG-Oligodeoxynucleotide

Antisense and Nucleic Acid Drug Development, 1999
Selected phosphorothioate oligodeoxynucleotides containing CpG (CpG-ODN) activate immune responses, including B-cell proliferation and cytokine production. The mechanism by which cells detect CpG-motifs is not known. There are conflicting reports in the literature concerning the ability of CpG-ODN linked to solid supports to stimulate immunity.
Donald E. Macfarlane, Lori Manzel
openaire   +3 more sources

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy

Current Opinion in Allergy & Clinical Immunology, 2021
Purpose of review Molecular forms of allergen-specific immunotherapy (AIT) are continuously emerging to improve the efficacy of the treatment, to shorten the duration of protocols and to prevent any side effects. The present review covers the recent progress in the development of AIT based on nucleic acid encoding allergens or ...
openaire   +2 more sources