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The immunobiology and clinical potential of immunostimulatory CpG oligodeoxynucleotides
Journal of Leukocyte Biology, 2000AbstractOver 100 years ago, Coley first explored the use of bacterial products as immunostimulatory therapy for nonbacterial disease. It is now clear that bacterial DNA, and synthetic oligodeoxynucleotides containing specific motifs centered on a CpG dinucleotide (CpG ODN), are potent immunostimulatory agents.
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Immunological Efficacy and Safety of Synthesized CpG Oligodeoxynucleotides
Applied Biochemistry and Microbiology, 2018The technology for synthesis is described, and the adjuvant properties of CpG oligodeoxynucleotides (CpG-ODNs) are assessed. CpG-ODN sequences were generated according to the available sequences on an automatic synthesizer. The adjuvant activity was evaluated with CpG-ODNs in combination with a recombinant protective antigen and EA1, an S-layer protein
O. M. Kudriavtseva +6 more
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CpG oligodeoxynucleotide-based therapy of lymphoid malignancies
Advanced Drug Delivery Reviews, 2009Preclinical and early clinical trials indicate synthetic oligodeoxynucleotides containing unmethylated CG dinucleotides (CpG ODN) have potent immunostimulatory effects. CpG ODN are being explored as immune adjuvants in vaccination strategies and as potential treatments for a wide variety of disorders including cancer and asthma.
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Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery.
Current Drug Delivery, 2004The main objective of these studies was to investigate whether the nanoparticle delivery has any immunopotentiation effect at modest doses of a few micro- or nanograms of CpG oligodeoxynucleotide (CpG ODN) and what would be the influence on T cell ...
M. Diwan +3 more
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Approaches to enhancing immune responses stimulated by CpG oligodeoxynucleotides
Advanced Drug Delivery Reviews, 2009CpG oligodeoxynucleotides (ODN) activate the immune system and are promising immunotherapeutic agents against infectious diseases, allergy/asthma and cancer. It has become apparent that while CpG ODN are potent immune activators in mice, their immune stimulatory effects are often less dramatic in humans and large animals. This disparity between rodents
George Mutwiri +3 more
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Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1999Immune stimulation has been widely recognized as an undesirable side effect of certain antisense oligodeoxynucleotides (ODN) which can interfere with their therapeutic application. It is now clear that these dose-dependent immune stimulatory effects primarily result from the presence of an unmethylated CpG dinucleotide in particular base contexts ('CpG
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CpG oligodeoxynucleotide induction of antiviral effector molecules in sheep
Cellular Immunology, 2004Immunostimulatory CpG oligodeoxynucleotide (ODN) can protect mice against infection by many pathogens but the mechanisms mediating disease protection are not well defined. Furthermore, the mechanisms of CpG ODN induced disease protection in vivo have not been investigated in other species.
Hugh G.G. Townsend +9 more
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Lipid-based delivery of CpG oligodeoxynucleotides for cancer immunotherapy
Expert Review of Clinical Pharmacology, 2009The anti-tumor activity of CpG-containing oligodeoxynucleotides (ODNs) has been well established in numerous animal models and confirmed in a number of early clinical trials. While the use of chemical modifications has effectively reduced the sensitivity of ODNs to nuclease degradation and a number of human trials have yielded promising results, the ...
Ying K. Tam, Kaley D. Wilson
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CpG Oligodeoxynucleotides and Monoclonal Antibody Therapy of Lymphoma
2002In the 1890’ s, Dr. William Coley reported on the use of heat killed bacterial extracts (Coley’ s toxin) to treat malignancy (1,2). His work, although promising, was associated with significant toxicity, and was difficult to reproduce. Additional attempts in the 20th century at immunotherapy of cancer involving nonspecific stimulation of the immune ...
Thomas L. Warren, George J. Weiner
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CpG oligodeoxynucleotides as DNA adjuvants in vertebrates and their applications in immunotherapy
International Immunopharmacology, 2006The genomes of bacterial and viral DNA contain a much higher frequency of unmethylated CpG dinucleotides than those of vertebrates. This difference in genome structure allows the innate immune system of vertebrates to distinguish bacterial or viral DNA from self-DNA, and consequently to perceive a 'danger signal' when bacterial or viral DNA is ...
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