Results 21 to 30 of about 5,254 (231)

CpG Oligodeoxynucleotides as Vaccine Adjuvants in Primates [PDF]

The Journal of Immunology, 2002
AbstractSynthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG ODN that stimulate human PBMC are only weakly active in mice. Thus, alternative animal models are needed to monitor the activity and safety of “human” CpG ODN in vivo ...
Dennis M. Klinman, Daniela Verthelyi, Robert A. Seder, Richard T. Kenney, Brenda Friedag, Albert A. Gam   +5 more
openaire   +3 more sources

Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production. [PDF]

PLoS ONE, 2016
Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability to enhance CpG-A phosphorothioate oligodeoxynucleotide (ODN)-mediated stimulation of IFNα production from human ...
Christopher S Malarkey, Claire E Gustafson, Jessica F Saifee, Raul M Torres, Mair E A Churchill, Edward N Janoff   +5 more
doaj   +1 more source

Adjuvant Activity of CpG Oligodeoxynucleotides [PDF]

International Reviews of Immunology, 2006
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Th1 and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells.
openaire   +4 more sources

Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock via Activation of Platelet-Activating Factor Acetylhydrolase

Frontiers in Immunology, 2017
Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto, Yoshinari Yamamoto, Ryu Sugimura, Takafumi Watanabe, Suguru Shigemori, Suguru Shigemori, Takuma Okajima, Shireen Nigar, Shireen Nigar, Fu Namai, Takashi Sato, Tasuku Ogita, Takeshi Shimosato, Takeshi Shimosato   +13 more
doaj   +1 more source

Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response

Scientific Reports, 2021
Antigen-adjuvant conjugation is known to enhance antigen-specific T-cell production in vaccine models, but scalable methods are required to generate site-specific conjugation for clinical translation of this technique.
Adam M. Weiss, Jainu Ajit, Tyler J. Albin, Neeraj Kapoor, Shilpa Maroju, Aym Berges, Lucy Pill, Jeff Fairman, Aaron P. Esser-Kahn   +8 more
doaj   +1 more source

Role of time reversal symmetry and tilting in circular photogalvanic responses [PDF]

Phys. Rev. B 103, 144308 (2021), 2020
We study the role of time reversal symmetry (TRS) in the circular photogalvanic (CPG) responses considering chiral Weyl semimetal (WSM) while a quantized CPG response is guaranteed by broken of both inversion symmetry (IS) and mirror symmetries. The TRS broken WSM yields one left and one right chiral Weyl nodes (WNs) while there are two left and right ...
arxiv   +1 more source

CXCL14 Acts as a Specific Carrier of CpG DNA into Dendritic Cells and Activates Toll-like Receptor 9-mediated Adaptive Immunity

EBioMedicine, 2017
CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various types
Kosuke Tanegashima, Rena Takahashi, Hideko Nuriya, Rina Iwase, Naoto Naruse, Kohei Tsuji, Akira Shigenaga, Akira Otaka, Takahiko Hara   +8 more
doaj   +1 more source

Reduction of CpG‐induced arthritis by suppressive oligodeoxynucleotides [PDF]

Arthritis & Rheumatism, 2002
AbstractObjectiveBacterial DNA contains immunostimulatory CpG motifs that cause inflammation when injected into the knee joints of normal mice. We examined whether synthetic oligodeoxynucleotides (ODN) that suppress CpG‐induced immune responses prevent CpG‐induced arthritis.MethodsCpG, suppressive, and/or control ODN were injected into the knees of ...
Ihsan Gursel, Martin J. Lizak, Rainald Zeuner, Dennis M. Klinman, Hiroshi Yamada, Daniela Verthelyi, Ken Ishii   +6 more
openaire   +3 more sources

Reinforcement Learning of CPG-regulated Locomotion Controller for a Soft Snake Robot [PDF]

, 2022
Intelligent control of soft robots is challenging due to the nonlinear and difficult-to-model dynamics. One promising model-free approach for soft robot control is reinforcement learning (RL). However, model-free RL methods tend to be computationally expensive and data-inefficient and may not yield natural and smooth locomotion patterns for soft robots.
arxiv   +1 more source

Decision Knowledge Graphs: Construction of and Usage in Question Answering for Clinical Practice Guidelines [PDF]

arXiv, 2023
In the medical domain, several disease treatment procedures have been documented properly as a set of instructions known as Clinical Practice Guidelines (CPGs). CPGs have been developed over the years on the basis of past treatments, and are updated frequently.
arxiv