Immunopharmacology of CpG Oligodeoxynucleotides and Ribavirin [PDF]
Antimicrobial Agents and Chemotherapy, 2004 ABSTRACT To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells.
Jörg, Vollmer +8 more
openaire +2 more sources
TLR9 mediates S. aureus killing inside osteoblasts via induction of oxidative stress [PDF]
, 2016 Background: Staphylococcus aureus is the principle causative pathogen of osteomyelitis and implant-associated bone infections. It is able to invade and to proliferate inside osteoblasts thus avoiding antibiotic therapy and the host immune system ...
Alt, Volker +7 more
core +4 more sources
Endotracheal tube-induced sore throat pain and inflammation is coupled to the release of mitochondrial DNA [PDF]
, 2017 In the absence of infection, the pathophysiology of endotracheal tube-induced sore throat pain is unclear. Activated neutrophils release elastase, reactive oxygen species, and inflammatory cytokines known to contribute to neuropathic pain. Sterile tissue
Earhart, Alexander +9 more
core +2 more sources
A CpG oligodeoxynucleotide enhances the immune response to rabies vaccination in mice. [PDF]
Virol J, 2018 Background Rabies is a fatal disease that is preventable when post exposure prophylaxis (PEP) is administered in a timely fashion. CpG oligodeoxynucleotides (ODNs) can trigger cells that express Toll-like receptor 9, and their immunopotentiation activity
Yu P +6 more
europepmc +2 more sources
Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects. [PDF]
, 2013 Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic ...
Fűri, István +6 more
core +1 more source
, 2005 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
Anders HJ, H-J Anders, Stacey KJ
core +1 more source
Frontiers in Immunology, 2017 Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock.
Yoshinari Yamamoto +13 more
doaj +1 more source
Mechanism of Mitochondrial Transcription Factor A Attenuation of CpG-Induced Antibody Production. [PDF]
PLoS ONE, 2016 Mitochondrial transcription factor A (TFAM) had previously been shown to act as a damage associated molecular pattern with the ability to enhance CpG-A phosphorothioate oligodeoxynucleotide (ODN)-mediated stimulation of IFNα production from human ...
Christopher S Malarkey +5 more
doaj +1 more source
Synergy effects of Polyinosinic-polycytidylic acid, CpG oligodeoxynucleotide, and cationic peptides to adjuvant HPV E7 epitope vaccine through preventive and therapeutic immunization in a TC-1 grafted mouse model. [PDF]
Hum Vaccin Immunother, 2018 Cross-talk by pattern recognition receptors may facilitate the maturation of dendritic cells and fine tune the immune response. Thus, the inclusion of ligands agonistic to multiple receptors in a vaccine formula may be an effective strategy to elicit ...
Liu C +6 more
europepmc +2 more sources
Adjuvant Activity of CpG Oligodeoxynucleotides [PDF]
International Reviews of Immunology, 2006 Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs directly stimulate human B cells and plasmacytoid dendritic cells (pDCs), thereby promoting the production of Th1 and proinflammatory cytokines and the maturation/activation of professional antigen-presenting cells.
openaire +2 more sources