Results 31 to 40 of about 9,596 (243)
Targeting STAT3 in Cancer with Nucleotide Therapeutics. [PDF]
, 2019 Signal transducer and activator of transcription 3 (STAT3) plays a critical role in promoting the proliferation and survival of tumor cells. As a ubiquitously-expressed transcription factor, STAT3 has commonly been considered an "undruggable" target for ...
Grandis, Jennifer R +3 more
core +2 more sources
Effects of CpG oligodeoxynucleotide 1826 on acute radiation-induced lung injury in mice. [PDF]
Biol Res, 2016 BACKGROUND: The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. CpG ODN is TLR9 activator with potential immune modulatory effects and sensitization of radiotherapy in lung cancer.
Li X, Xu G, Qiao T, Yuan S, Zhuang X.
europepmc +2 more sources
Data on the uptake of reducible antigen-adjuvant conjugates by dendritic cells
Data in Brief, 2019 This article contains the uptake data of two reducible antigen-adjuvant conjugates with different sensitivities to the extracellular and intracellular reductive environment.
Katrin Kramer +2 more
doaj +1 more source
CpG Oligodeoxynucleotides as Vaccine Adjuvants in Primates [PDF]
The Journal of Immunology, 2002 Abstract Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs act as immune adjuvants in mice, boosting the humoral and cellular response to coadministered Ags. CpG ODN that stimulate human PBMC are only weakly active in mice.
Daniela, Verthelyi +5 more
openaire +2 more sources
Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]
, 2015 We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F +3 more
core +3 more sources
Protective immunity against Trypanosoma cruzi [PDF]
, 2009 Upon infection, Trypanosoma cruzi triggers a strong immune response that has both protective and pathological consequences. In this work, several important questions regarding protective immunity are reviewed.
Basombrío, Miguel Ángel Manuel +2 more
core +1 more source
EBioMedicine, 2017 CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. However, the underlying molecular mechanisms are unclear. Here, we show that CXCL14 transports various types
Kosuke Tanegashima +8 more
doaj +1 more source
Molecular mechanisms of autoimmunity triggered by microbial infection [PDF]
, 2005 Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives.
Anders, Hans-Joachim +3 more
core +2 more sources
Scientific Reports, 2021 Antigen-adjuvant conjugation is known to enhance antigen-specific T-cell production in vaccine models, but scalable methods are required to generate site-specific conjugation for clinical translation of this technique.
Adam M. Weiss +8 more
doaj +1 more source
CpG-Oligodeoxynucleotide Treatment Protects against Ionizing Radiation-Induced Intestine Injury. [PDF]
PLoS One, 2013 the bone marrow and the intestine are the major sites of ionizing radiation (IR)-induced injury. Our previous study demonstrated that CpG-oligodeoxynucleotide (ODN) treatment mitigated IR-induced bone marrow injury, but its effect on the intestine is not
Zhang C +7 more
europepmc +2 more sources