Results 31 to 40 of about 5,254 (231)

Modeling DNA methylation dynamics with approaches from phylogenetics [PDF]

Bioinformatics 30 (2014) i408-i414, 2014
Methylation of CpG dinucleotides is a prevalent epigenetic modification that is required for proper development in vertebrates, and changes in CpG methylation are essential to cellular differentiation. Genome-wide DNA methylation assays have become increasingly common, and recently distinct stages across differentiating cellular lineages have been ...
arxiv   +1 more source

Oral pretreatment with β-lactoglobulin derived peptide and CpG co-encapsulated in PLGA nanoparticles prior to sensitizations attenuates cow’s milk allergy development in mice

Frontiers in Immunology, 2023
Cow’s milk allergy is a common food allergy among infants. Improved hygiene conditions and loss of microbial diversity are associated with increased risk of allergy development. The intestinal immune system is essential for oral tolerance induction.
Mengshan Liu, Mengshan Liu, Suzan Thijssen, Wim E. Hennink, Johan Garssen, Johan Garssen, Cornelus F. van Nostrum, Linette E. M. Willemsen   +7 more
doaj   +1 more source

CpG oligodeoxynucleotide stimulates production of anti-neutrophil cytoplasmic antibodies in ANCA associated vasculitis

BMC Immunology, 2008
Background Wegener's Granulomatosis and Microscopic Polyangiitis are life-threatening systemic necrotizing vasculitides of unknown aetiology. The appearance of circulating antibodies to neutrophil cytoplasmic antigens (ANCA) is strongly associated with ...
Sarvestani Ghafar, Patel Mittal, Nitschke Jodie, Jeffs Lisa, Hurtado Plinio R, Cassidy John, Hissaria Pravin, Gillis David, Au Peh Chen   +8 more
doaj   +1 more source

Alkaline Adjuvant Regulates Proteolytic Activity of Macrophages for Antigen Cross-Presentation and Potentiates Radioimmunotherapy. [PDF]

Adv Mater
Tissue‐repairing macrophages compromise radiotherapy‐induced antitumor immunity. An alkaline adjuvant (MgAl‐based hydrotalcite, bLDH) reverses the situation. After engendering macrophages to phagocytose irradiated cancer cells, bLDH is administrated and improves the cross‐presentation of engulfed tumor antigens over tenfold. bLDH limits the activity of
Li B, Tan Y, Lei JH, Deng M, Yu X, Wang X, Lei LM, He L, Deng CX, Dai Y.   +9 more
europepmc   +2 more sources

Systemic Administration of CpG Oligodeoxynucleotide and Levamisole as Adjuvants for Gene-Gun-Delivered Antitumor DNA Vaccines

Clinical and Developmental Immunology, 2011
DNA vaccines showed great promise in preclinical models of infectious and malignant diseases, but their potency was insufficient in clinical trials and is needed to be improved.
Michal Šmahel, Ingrid Poláková, Eva Sobotková, Eva Vajdová   +3 more
doaj   +1 more source

Integrating Contact-aware Feedback CPG System for Learning-based Soft Snake Robot Locomotion Controllers [PDF]

arXiv, 2023
This paper aims to solve the contact-aware locomotion problem of a soft snake robot by developing bio-inspired contact-aware locomotion controllers. To provide effective contact information for the controllers, we develop a scale-covered sensor structure mimicking natural snakes' scale sensilla.
arxiv  

Predicting genome-wide DNA methylation using methylation marks, genomic position, and DNA regulatory elements [PDF]

, 2013
Background: Recent assays for individual-specific genome-wide DNA methylation profiles have enabled epigenome-wide association studies to identify specific CpG sites associated with a phenotype. Computational prediction of CpG site-specific methylation levels is important, but current approaches tackle average methylation within a genomic locus and are
arxiv   +1 more source

Self-assembled immunostimulatory nanosphere combined with PD-L1 to enhanced cancer chemoimmunotherapy

Materials & Design, 2022
Induction of antigen-specific immune response by maturing dendritic cells (DCs) is a promising strategy for anti-tumor immunotherapy. However, the immunosuppressive tumor microenvironment (TME) and the ineffective tumor-associated antigen (TAAs ...
Haihui Wang, Xiaohui Zhu, Han Xiao, Yongfei Liu, Zhangcheng Fu, Yihang Ding, Chunsen Li, Chunhua Lu, Xiankun Tu   +8 more
doaj  

Synergistic oligodeoxynucleotide strongly promotes CpG-induced interleukin-6 production

BMC Immunology, 2017
Background Bacterial genomes span a significant portion of diversity, reflecting their adaptation strategies; these strategies include nucleotide usage biases that affect chromosome configuration.
Shireen Nigar, Yoshinari Yamamoto, Takuma Okajima, Suguru Shigemori, Takashi Sato, Tasuku Ogita, Takeshi Shimosato   +6 more
doaj   +1 more source

Multiple chaotic central pattern generators with learning for legged locomotion and malfunction compensation [PDF]

, 2014
An originally chaotic system can be controlled into various periodic dynamics. When it is implemented into a legged robot's locomotion control as a central pattern generator (CPG), sophisticated gait patterns arise so that the robot can perform various walking behaviors.
arxiv   +1 more source