Results 41 to 50 of about 9,596 (243)

SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7 [PDF]

, 2014
Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells.
Chaperot, L., Chen, Jianzhu, Du, P., Guo, H., Li, J., Liu, Y., Plumas, J., Su, L., Wang, Y., Yin, X., Yu, H., Zhang, J., Zhang, L., Zhang, X.   +13 more
core   +1 more source

CpG Oligodeoxynucleotides Enhance Host Defense during Murine Tuberculosis [PDF]

Infection and Immunity, 2002
ABSTRACTOligodeoxynucleotides (ODNs) containing unmethylated CpG motifs activate immune cells to produce cytokines. CpG ODNs protect mice against infections with intracellular bacteria by the induction of a T helper 1 (Th1) response. To determine the effect of CpG ODNs in pulmonary tuberculosis, mice were treated with CpG ODNs or control ODNs at the ...
Juffermans, Nicole P., Leemans, Jaklien C., Florquin, Sandrine, Verbon, Annelies, Kolk, Arend H., Speelman, Peter, van Deventer, Sander J. H., van der Poll, Tom   +7 more
openaire   +3 more sources

TLR9-based immunotherapy for the treatment of allergic diseases [PDF]

, 2017
Toll-like receptors (TLRs), a family of pattern recognition receptors expressed on many cell types of innate immunity, recognize the pathogen-associated molecular patterns of microbes.
Akira S, Ali Movahed, Farrokhi S, Hoshino K, Hossein Ali Khazaei, Kline JN, Masoud Pishjoo, Narjes Abbasirad, Nima Rezaei, Shokrollah Farrokhi, Spiegelberg HL, Sur S   +11 more
core   +1 more source

CpG oligodeoxynucleotide stimulates production of anti-neutrophil cytoplasmic antibodies in ANCA associated vasculitis

BMC Immunology, 2008
Background Wegener's Granulomatosis and Microscopic Polyangiitis are life-threatening systemic necrotizing vasculitides of unknown aetiology. The appearance of circulating antibodies to neutrophil cytoplasmic antigens (ANCA) is strongly associated with ...
Sarvestani Ghafar, Patel Mittal, Nitschke Jodie, Jeffs Lisa, Hurtado Plinio R, Cassidy John, Hissaria Pravin, Gillis David, Au Peh Chen   +8 more
doaj   +1 more source

Breast cancer as photodynamic therapy target: Enhanced therapeutic efficiency by overview of tumor complexity [PDF]

, 2014
Photodynamic therapy is a minimally invasive and clinically approved procedure for eliminating selected malignant cells with specific light activation of a photosensitizer agent.
Lamberti, María Julia, Rivarola, Viviana, Rumie Vittar, Natalia Belen   +2 more
core   +1 more source

Oral pretreatment with β-lactoglobulin derived peptide and CpG co-encapsulated in PLGA nanoparticles prior to sensitizations attenuates cow’s milk allergy development in mice

Frontiers in Immunology, 2023
Cow’s milk allergy is a common food allergy among infants. Improved hygiene conditions and loss of microbial diversity are associated with increased risk of allergy development. The intestinal immune system is essential for oral tolerance induction.
Mengshan Liu, Mengshan Liu, Suzan Thijssen, Wim E. Hennink, Johan Garssen, Johan Garssen, Cornelus F. van Nostrum, Linette E. M. Willemsen   +7 more
doaj   +1 more source

Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation [PDF]

, 2016
PURPOSE: We previously reported that applying toll-like receptor (TLR) ligands to an injured cornea induces corneal edema at 24 hours, which subsides by 1 week.
Larkin, DFP
core   +1 more source

CpG-coated prussian blue nanoparticles-based photothermal therapy combined with anti-CTLA-4 immune checkpoint blockade triggers a robust abscopal effect against neuroblastoma

Translational Oncology, 2020
High-risk neuroblastoma, which is associated with regional and systemic metastasis, is a leading cause of cancer-related mortality in children. Responding to this need for novel therapies for high-risk patients, we have developed a “nanoimmunotherapy ...
Juliana Cano-Mejia, Anshi Shukla, Debbie K. Ledezma, Erica Palmer, Alejandro Villagra, Rohan Fernandes   +5 more
doaj   +1 more source

Nanoparticle‐Based Tolerogenic Vaccines: Next‐Generation Strategies for Autoimmune and Allergic Disease Therapies

Angewandte Chemie, Volume 138, Issue 6, 2 February 2026.
Nanoparticle‐based tolerogenic vaccines harness controlled antigen delivery and immunomodulation to establish tolerance in autoimmunity and allergy. This review outlines how nanoparticle design (size, shape, composition, administration route) influences biodistribution and immune‐cell targeting.
Benjamin E. Nachod, Ajay S. Thatte, Rohan Palanki, Michael J. Mitchell   +3 more
wiley   +2 more sources

Oligodeoxynucleotide inhibition of Toll-like receptors 3, 7, 8, and 9 suppresses cytokine production in a human rheumatoid arthritis model [PDF]

, 2015
Toll-like receptors (TLRs) are innate immune receptors that respond to both exogenous and endogenous stimuli and are suggested to contribute to the perpetuation of chronic inflammation associated with rheumatoid arthritis (RA).
Alzabin, Barrat, Barrat, Brennan, Brennan, Brentano, Buchan, Butler, Chamberlain, Chen, Dong, Feldmann, Foell, Foxwell, Guiducci, Haas, Herman, Iwahashi, Krieg, Latz, Lenert, Levin, Lundberg, Martinon, Meng, Midwood, Mosmann, Nardo, Ospelt, Radstake, Ranjith-Kumar, Roelofs, Rutault, Sacre, Sacre, Seibl, Shirota, Uematsu, Yanai, Yanai, Zeuner   +40 more
core   +1 more source